RNAP3D

Multi-subunit RNA polymerase composition

Subunit alignment table of multi-subunit RNA polymerase is shown, same color represents homologous subunits. Generally, the RNA core polymerase of prokaryotes contains 5 subunits, the RNA polymerase of archeae has 13 subunits, and there are three main types of eukaryotic RNA polymerases: RNAPI (14 subunits), RNAPII (12 subunits) subunits) and RNAPIII (17 subunits).

Multi-subunit RNA polymerase transcription factors

Table of transcription factors for multisubunit RNA polymerases is shown. Same color represents homologous transcription factors.

TBP,TATA box-binding protein.Factors with structural homologies are marked in bold letters. The yeast name and the mammalian name (in squared brackets) of the homologous protein are given. If these proteins are complex components, the name of the respective complex is depicted in round brackets.

Conserve and diverse subunits mapping on structure of multi-subunit RNA polymerase

   Crystal structure of multi-subunit RNA polymerase:

Structure of multisubunit RNA polymerase are shown. Same color represents homologous subunits

Prokaryote
 
4 subunits
PDB code:2O5I
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Archaea
 
11-13 subunits
PDB code:2WAQ
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Eukaryote
 
RNAP I
 
12 subunits
PDB code:4C3H
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RNAP II
 
15 subunits
PDB code:1Y1W
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RNAP III
 
17 subunits
PDB code:5FJ8
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   Scheme of multi-subunit RNA polymerase subunit composition:

The relative positions of subunits of multisubunit RNA polymerase are shown. Same colors represent homologous subunits.

Prokaryote
Archaea
RNAP I
RNAP III
RNAP II
RNAP IV
RNAP V

   Eukaryotic RNA polymerase subunit interaction:

Interactions between subunits of eukaryotic RNA polymerases are shown. The thickness of the black line represents the strength of the subunit interaction.

RNAP I
RNAP II
RNAP III
Shared and distinct subunits of Pol II vs IV or V

Single-subunit RNA polymerase overall structure

Structures of single-subunit RNA polymerase are shown: single-strand positive RNA virus, single-strand negative RNA virus, double-strand positive RNA virus and double-strand DNA virus.

Single-strand positive RNA virus
Organism:Human poliovirus
PDB code:1HHS
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Single-strand negative RNA virus
Organism:Influenza A virus
PDB code:4WSB
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Double-strand positive RNA virus
Organism:Pseudomonas virus phi6
PDB code:4A8F
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Double-strand DNA virus
Organism:Escherichia phage T7
PDB code:1S0V
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