The small-molecule RNAP inhibitors of HCV:


The structures of all RNA polymerases are superimposed, and the pockets where the inhibitors bind intensively are found and numbered pocket 1, pocket 2, pocket 3, etc. A table of inhibitors in each pocket, including inhibitor name, drug name, 2D structure, and 3D visualization.The ID and PDB are linked to PDB database.

Pocket ID PDB Name Drug 2D Diagram 3D Interaction
Pocket1 E4Z 6SF8 Baloxavir acid Baloxavir
6SF9
Pocket2 BYB 6EUX (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid