The small-molecule RNAP inhibitors of ZIKV:


The structures of all RNA polymerases are superimposed, and the pockets where the inhibitors bind intensively are found and numbered pocket 1, pocket 2, pocket 3, etc. A table of inhibitors in each pocket, including inhibitor name, drug name, 2D structure, and 3D visualization.The ID and PDB are linked to PDB database.

Pocket ID PDB Name Drug 2D Diagram 3D Interaction
Pocket G8O 6LD3 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid
6LD4
6LD5
KY3 6LD2 (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid