| 5K5M |
XRD |
Virus |
Dengue virus(DENV) |
Co-crystal structure of dengue virus serotype 2 RNAP with compound 27 |
27500641 |
2.01 Å |
RNAP |
RNAP (NS5) |
68T[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide ] , MES[ 2-(N-MORPHOLINO)-ETHANESULFONIC ACID ], ZN |
| 2J7U |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus NS5 RNAP domain |
17301146 |
1.85 Å |
RNAP |
RNAP (NS5) |
PGE[TRIETHYLENE GLYCOL], ZN, CL, MG |
| 2J7W |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus NS5 RNAP domain complexed with 3' dGTP |
17301146 |
2.60 Å |
RNAP |
RNAP (NS5) |
GTP[ GUANOSINE-5'-TRIPHOSPHATE ], PEG[ DI(HYDROXYETHYL)ETHER ],ZN |
| 4C11 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus RNAP with residues from the NS5 linker region |
24025331 |
2.60 Å |
RNAP |
RNAP (NS5) |
ZN |
| 4HHJ |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP |
23408636 |
1.79 Å |
RNAP |
RNAP (NS5) |
P6G[ HEXAETHYLENE GLYCOL ], PEG[ DI(HYDROXYETHYL)ETHER ], ZN |
| 5DTO |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus full length NS5 complexed with viral cap 0-RNA and SAH |
26578813 |
2.60 Å |
RNAP |
RNAP (NS5) |
M7G[ 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE ], SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], ACT[ ACETATE ION ], ZN,MG |
| 5F3T |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to JF-31-MG46 |
26872970 |
2.05 Å |
RNAP |
RNAP (NS5) |
5UH[ 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid ], ZN |
| 5F3Z |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to PC-79-SH52 |
26872970 |
2.00 Å |
RNAP |
RNAP (NS5) |
5V5[ 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid ], ZN |
| 5F41 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to FD-83-KI26 |
26872970 |
2.00 Å |
RNAP |
RNAP (NS5) |
5V6[ 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid ], ZN |
| 5HMW |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 5 |
26984786 |
2.15 Å |
RNAP |
RNAP (NS5) |
LNW[ 2,2'-biphenyl-3,5-diyldiacetic acid ] , ZN |
| 5HMX |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 10 |
26984786 |
2.40 Å |
RNAP |
RNAP (NS5) |
LNX[ 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid ],ZN |
| 5HMY |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 15 |
26984786 |
2.10 Å |
RNAP |
RNAP (NS5) |
LNY[ 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid ], ZN |
| 5HMZ |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 23 |
26984786 |
1.99 Å |
RNAP |
RNAP (NS5) |
LNZ[ 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide ] ,ZN |
| 5HN0 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 4 |
26984786 |
2.05 Å |
RNAP |
RNAP (NS5) |
LNN[ (6-hydroxybiphenyl-3-yl)acetic acid ] ,ZN |
| 5I3P |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 27 |
27500641 |
2.45 Å |
RNAP |
RNAP (NS5) |
68T[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide ] , ZN |
| 5I3Q |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 29 |
27500641 |
1.88 Å |
RNAP |
RNAP (NS5) |
68E[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide ],ZN |
| 5IQ6 |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue virus serotype 3 RNAP bound to HEE1-2TYR, a new pyridobenzothizole inhibitor |
27649989 |
3.00 Å |
RNAP |
RNAP (NS5) |
6CJ[ N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine ] , ZN |
| 5JJR |
XRD |
Virus |
Dengue virus(DENV) |
Dengue 3 NS5 protein with compound 29 |
27500641 |
1.99 Å |
RNAP |
RNAP (NS5) |
68E[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide ] ,SAH[ S-ADENOSYL-L-HOMOCYSTEINE ]、PEG[ DI(HYDROXYETHYL)ETHER ],EDO[ 1,2-ETHANEDIOL ], ZN,MG |
| 5JJS |
XRD |
Virus |
Dengue virus(DENV) |
Dengue 3 NS5 protein with compound 27 |
27500641 |
1.65 Å |
RNAP |
RNAP (NS5) |
6L2[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-{[(1R,3R)-3-methoxycyclohexyl]sulfonyl}benzamide ] 、 SAH[ S-ADENOSYL-L-HOMOCYSTEINE ]、PEG[ DI(HYDROXYETHYL)ETHER ]、EDO[ 1,2-ETHANEDIOL ]、 ZN、 MG |
| 6H80 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue-RDRP3-inhibitor complex co-crystallisation |
30602529 |
2.30 Å |
RNAP |
RNAP (NS5) |
5V5[ 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid ] ,PEG[ DI(HYDROXYETHYL)ETHER ],ZN |
| 6H9R |
XRD |
Virus |
Dengue virus(DENV) |
Dengue-RDRP3-inhibitor complex soaking |
30602529 |
2.40 Å |
RNAP |
RNAP (NS5) |
5V5[ 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid ] ,PEG[ DI(HYDROXYETHYL)ETHER ], ZN |
| 3VWS |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to NITD-107 |
23408636 |
2.10 Å |
RNAP |
RNAP (NS5) |
VWS[ 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid ], PEG[ DI(HYDROXYETHYL)ETHER ], ZN |
| 1L9K |
XRD |
Virus |
Dengue virus(DENV) |
Dengue methyltransferase |
12032088 |
2.40 Å |
Subunit |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4 |
| 1R6A |
XRD |
Virus |
Dengue virus(DENV) |
Structure of the dengue virus 2'o methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate |
15152003 |
2.60 Å |
Subunit |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],RVP[ RIBAVIRIN MONOPHOSPHATE ], SO4 |
| 5HHG |
XRD |
Virus |
Dengue virus(DENV) |
Mouse Importin alpha: dengue 2 NS5 C-terminal NLS peptide complex |
27622521 |
2.20 Å |
Subunit |
RNAP (NS5) ,Importin Subunit Alpha-1 |
|
| 6IZZ |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 3 NS5, bound with rk-0404678 |
31738758 |
1.97 Å |
RNAP |
RNAP (NS5) |
B5C[ 2-oxo-2H-1,3-benzoxathiol-5-yl acetate ] , ZN |
| 6J00 |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 3 NS5 |
31738758 |
2.14 Å |
RNAP |
RNAP (NS5) |
ZN |
| 6XD1 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to NITD-640 |
32907977 |
1.95 Å |
RNAP |
RNAP (NS5) |
V0J[ (2R)-4-(butyl{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}carbamoyl)-1-(2,2-diphenylpropanoyl)piperazine-2-carboxylic acid ], ZN |
| 3EVG |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue-2 virus methyltransferase complexed with s-adenosyl-l-homocysteine |
19101564 |
2.20 Å |
Subunit |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4 |
| 6KR2 |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue virus nonstructural protein NS5 (form 1) |
32357182 |
3.06 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],ZN |
| 6KR3 |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue virus nonstructural protein NS5 (form 2) |
32357182 |
2.93 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],IOD[ IODIDE ION ],GOL, ZN |
| 6IZX |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 2 NS5, bound with rk-0404678 |
31738758 |
2.43 Å |
RNAP |
RNAP (NS5) |
B5C[ 2-oxo-2H-1,3-benzoxathiol-5-yl acetate ],ZN、CO |
| 6IZY |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 2 NS5 |
31738758 |
2.11 Å |
Subunit |
RNAP (NS5) |
ZN,CO |
| 6XD0 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to NITD-434 |
32907977 |
2.01 Å |
RNAP |
RNAP (NS5) |
V0M[ 2-[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid ],PEG [ DI(HYDROXYETHYL)ETHER ],GOL ,MN |
| 3P8Z |
XRD |
Virus |
Dengue virus(DENV) |
Dengue methyltransferase bound to a sam-based inhibitor |
21147775 |
1.70 Å |
Subunit |
RNAP (NS5) |
36A??(S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid?? SAH??S-ADENOSYL-L-HOMOCYSTEINE?? |
| 3P97 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue 3 NS5 methyltransferase bound to the substrate s-adenosyl methionine |
21147775 |
1.70 Å |
Subunit |
RNAP (NS5) |
SAM[ S-ADENOSYLMETHIONINE ] |
| 5CCV |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of full-length NS5 from dengue virus type 3 |
26895240 |
3.60 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ] , ZN |
| 4V0Q |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus full length NS5 complexed with sah |
25775415 |
2.30 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],GOL, ZN, ACT[ ACETATE ION ] |
| 4V0R |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus full length NS5 complexed with GTP and sah |
25775415 |
2.40 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ] , GTP, GOL[ GLYCEROL ],ZN, FMT [FORMIC ACID], MG |
| 3EVG |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of Dengue-2 virus methyltransferase complexed with S-adenosyl-L-homocysteine |
19101564 |
2.20Å |
Subunit |
RNAP NS5 |
SAH [ S-ADENOSYL-L-HOMOCYSTEINE ] SO4 |