RNAP3D

PDB Method Taxonomy Organism Name Reference_pub Resolution Stage  Contents   Ligands 
6QNW XRD Virus Influenza A virus(FluA) influenza A polymerase heterotrimer human H3N2 northern territory 1968 31485076 3.31 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
6QPG XRD Virus Influenza A virus(FluA) influenza A virus polymerase heterotrimer a/nt/60/1968(H3N2) in complex with nanobody NB8205 31485076 3.34 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Nanobody NB8205
6QX8 EM Virus Influenza A virus(FluA) influenza A virus (A/nt/60/1968) polymerase dimer of heterotrimer in complex with 5' cRNA promoter 31485076 4.07 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
6QXE EM Virus Influenza A virus(FluA) influenza A virus (A/nt/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' cRNA promoter and NB8205 31485076 4.15 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,NB8205
6RR7 EM Virus Influenza A virus(FluA) influenza A virus (A/nt/60/1968) polymerase heterotrimer bound to 3'5' vRNA promoter and capped RNA primer 31485076 3.01 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
6QX3 EM Virus Influenza A virus(FluA) influenza A virus (A/nt/60/1968) polymerase hetermotrimer in complex with 3'5' cRNA promoter and NB8205 31485076 3.79 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,NB8205
6QPF XRD Virus Influenza A virus(FluA) influenza A virus polymerase heterotrimer A/duck/fujian/01/2002(H5N1) 31485076 3.63 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
4NFZ XRD Virus Influenza A virus(FluA) Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10 24284327 2.70 Å Subunit Polymerase PA MN
4WSB XRD Virus Influenza A virus(FluA) Bat influenza A polymerase with bound vRNA promoter 25409151 2.65 Å RNAP Polymerase PA,RNAP Catalytic Subunit,Polymerase PB2 PO4, ZN
5M3H XRD Virus Influenza A virus(FluA) Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated pol II CTD 28002402 2.50 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Tyr-Ser-Pro-Thr-Sep-Pro PO4, ZN
6EVJ XRD Virus Influenza A virus(FluA) Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer 29202182 3.90 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
6EVK XRD Virus Influenza A virus(FluA) Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP 29202182 2.90 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 MGP[7-METHYL-GUANOSINE-5'-TRIPHOSPHATE] , PO4, ZN
6FHH XRD Virus Influenza A virus(FluA) Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified pol II CTD peptide with serine 5 thiophosphorylated. To be published. 2.70 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 PO4, ZN
6FHI XRD Virus Influenza A virus(FluA) Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated pol II CTD peptide with a truncated linker. To be published. 2.80 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 PO4, ZN
6SZU EM Virus Influenza A virus(FluA) Bat influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence 32304664 2.41 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], POP[ PYROPHOSPHATE 2- ], MG
6SZV EM Virus Influenza A virus(FluA) Bat influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) 32304664 2.50 Å EC Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uri], M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], MG
6T0N EM Virus Influenza A virus(FluA) Bat influenza A polymerase pre-initiation complex 32304664 2.54 Å pIC Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 MG
6T0R EM Virus Influenza A virus(FluA) Bat influenza A polymerase product dissociation complex using 44-mer vRNA template with mutated oligo(U) sequence 32304664 2.82 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
6T0S EM Virus Influenza A virus(FluA) Bat influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence 32304664 3.04 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 MG
6T0U EM Virus Influenza A virus(FluA) Bat influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence 32304664 3.12 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2
6T0V EM Virus Influenza A virus(FluA) Bat influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) 32304664 3.02 Å EC Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine], M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], MG
6T2C EM Virus Influenza A virus(FluA) Bat influenza A polymerase recycling complex 32304664 3.52 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 MG
6TW1 EM Virus Influenza A virus(FluA) Bat influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence 32304664 2.70 Å TC Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], POP[ PYROPHOSPHATE 2- ], MG
4IUJ XRD Virus Influenza A virus(FluA) Structure of polymerase acid protein (PA) from influenzavirus a influenza A virus A, wilson-smith/1933 (H1N1) 25089892 1.90 Å RNAP Polymerase Acidic Protein
5IEQ XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole To be published. 2.20 Å RNAP Polymerase Acidic Protein 1CI[1-(4-CHLOROPHENYL)-1H-IMIDAZOLE] , DMS[DIMETHYL SULFOXIDE]
5IF2 XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol To be published. 2.35 Å RNAP Polymerase Acidic Protein 6B1[(5,6-dichloro-1H-benzimidazol-2-yl)methanol] , DMS[DIMETHYL SULFOXIDE], CL
5IF5 XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol To be published. 2.25 Å RNAP Polymerase Acidic Protein 6B0[(2,3-dichlorophenyl)methanol], DMS[DIMETHYL SULFOXIDE], EDO[1,2-ETHANEDIOL]
5IF7 XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine To be published. 2.65 Å RNAP Polymerase Acidic Protein 6AY[N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine] , DMS[DIMETHYL SULFOXIDE]
5IF8 XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine To be published. 2.30 Å RNAP Polymerase Acidic Protein 6AX[5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine] , GOL, DMS[DIMETHYL SULFOXIDE], EDO[1,2-ETHANEDIOL], CL
5IFB XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4719 5-chloro-2-(1h-imidazol-1-yl)aniline To be published. 2.45 Å RNAP Polymerase Acidic Protein 6AV[5-chloro-2-(1H-imidazol-1-yl)aniline] , DMS[DIMETHYL SULFOXIDE], CL
5IFC XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4720 1-(4-bromophenyl)-1H-imidazole To be published. 2.65 Å RNAP Polymerase Acidic Protein 6AR[1-(4-bromophenyl)-1H-imidazole] , DMS[DIMETHYL SULFOXIDE]
5IFD XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4721 1-(4-fluorophenyl)-1H-imidazole To be published. 2.65 Å RNAP Polymerase Acidic Protein 6AQ[1-(4-fluorophenyl)-1H-imidazole] , DMS[DIMETHYL SULFOXIDE]
5V0U XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4723 4-(5-chlorothiophen-2-yl)-1H-pyrazole To be published. 2.45 Å RNAP Polymerase Acidic Protein 8QG[4-(5-chlorothiophen-2-yl)-1H-pyrazole]
6CFP XRD Virus Influenza A virus(FluA) Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit bsi-70565 1-{1-[4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one To be published. 2.45 Å RNAP Ubiquitin-Like Protein Smt3,Polymerase Acidic Protein EZS[1-{1-[(4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one] , DMS[DIMETHYL SULFOXIDE]
4AVG XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2 22876177 2.20 Å Subunit Polymerase PA SL6 [(Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid] , MN
4AVL XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with dTMP 22876177 1.87 Å Subunit Polymerase PA TMP[THYMIDINE-5'-PHOSPHATE] , MN
4AVQ XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease 22876177 2.10 Å Subunit Polymerase PA MN, MG
4AWF XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2 4-dioxo-4-phenylbutanoic acid dpba 22876177 2.30 Å RNAP Polymerase PA XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID] , MN
4AWG XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3 22876177 2.60 Å Subunit Polymerase PA CI3[(2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid] , SO4, MN
4AWH XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with RUMP 22876177 2.05 Å Subunit Polymerase PA U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN
4AWK XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1 22876177 1.90 Å Subunit Polymerase PA CI1[(2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid] , MN
4AWM XRD Virus Influenza A virus(FluA) Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea 22876177 2.60 Å Subunit Polymerase PA KDH[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate] , MN
5CCY XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease in complex with dTMP 26976575 2.10 Å Subunit Polymerase Acidic Protein TMP[THYMIDINE-5'-PHOSPHATE] , MN
5CGV XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease in complex with l-742,001 26976575 2.17 Å Subunit Polymerase Acidic Protein 0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , GOL, MN
5CL0 XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease in complex with rUMP 26976575 2.22 Å Subunit Polymerase Acidic Protein U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN
5CZN XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant E119D 26976575 1.98 Å Subunit Polymerase Acidic Protein SO4, MN
5D2O XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant F105S 26976575 2.15 Å Subunit Polymerase Acidic Protein MN
5D42 XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant F105S in complex with dTMP 26976575 2.00 Å Subunit Polymerase Acidic Protein TMP[THYMIDINE-5'-PHOSPHATE] , MN
5D4G XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant F105S in complex with RUMP 26976575 2.08 Å Subunit Polymerase Acidic Protein U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN
5D8U XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant E119D in complex with l-742,001 26976575 2.29 Å Subunit Polymerase Acidic Protein 0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , MN
5D9J XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant F105S in complex with l-742,001 26976575 1.85 Å Subunit Polymerase Acidic Protein 0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , MN
5DBS XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant E119D in complex with dTMP 26976575 2.11 Å Subunit Polymerase Acidic Protein TMP[THYMIDINE-5'-PHOSPHATE] , SO4,MN
5DEB XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease mutant E119D in complex with rUMP 26976575 2.14 Å Subunit Polymerase Acidic Protein U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN
5DES XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease domain 26976575 2.05 Å Subunit Polymerase Acidic Protein MN
5EGA XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease domain in complex with an N-acylhydrazone inhibitor 27510745 2.15 Å Subunit Polymerase Acidic Protein GK0[3,4,5-tris(oxidanyl)-~{N}-[(~{E})-[3,4,5-tris(oxidanyl)phenyl]methylideneamino]benzamide] , MN
5VP8 XRD Virus Influenza A virus(FluA) I38T mutant of 2009 H1N1 PA endonuclease 29691337 2.20 Å Subunit Polymerase Acidic Protein 9HD(1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one), SO4,MN
5VPT XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease in complex with RO-7 29691337 2.10 Å Subunit Polymerase Acidic Protein R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN
5VPX XRD Virus Influenza A virus(FluA) I38T mutant of 2009 H1N1 PA endonuclease in complex with RO-7 29691337 2.30 Å Subunit Polymerase Acidic Protein R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN
5VQN XRD Virus Influenza A virus(FluA) E119d mutant of 2009 H1N1 PA endonuclease in complex with RO-7 29691337 2.00 Å Subunit Polymerase Acidic Protein R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN
5VRJ XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease in complex with RO-7 and magnesium 29691337 2.30 Å Subunit Polymerase Acidic Protein R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN
5W3I XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6e (SRI-29685) 29215062 1.95 Å Subunit Polymerase Acidic Protein GY5[5-hydroxy-N-(2-methoxyethyl)-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxamide] , GOL, MN
5W44 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7a (SRI-29770) 29215062 2.10 Å Subunit Polymerase Acidic Protein GY6[2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , MN, MG, NA
5W73 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9f (SRI-29835) 29215062 2.20 Å Subunit Polymerase Acidic Protein GY9[2-{(2S)-1-[(2-chlorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5W7U XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 8f (SRI-29928) 29215062 2.20 Å Subunit Polymerase Acidic Protein GY8[2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-N-(2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1,6-dihydropy rimidine-4-carboxamide] , MN
5W92 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30049 29215062 2.30 Å Subunit Polymerase Acidic Protein KU0 [2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide), 9HD[1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one], MN
5W9G XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9k (SRI-30023) 29215062 2.10 Å Subunit Polymerase Acidic Protein KU2[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4 -carboxamide] , SO4, MN, CL
5WA6 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30007 29215062 2.25 Å Subunit Polymerase Acidic Protein KU7[2-{(2S)-1-[(2-fluorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , MN
5WA7 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9b (SRI-30101) 29215062 2.20 Å Subunit Polymerase Acidic Protein KU4[2-{(2S)-1-[3-(2-chlorophenyl)propanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WAP XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10i (SRI-30025) 29215062 2.20 Å Subunit Polymerase Acidic Protein KU9[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WB3 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10j (SRI-30026) 29215062 2.20 Å Subunit Polymerase Acidic Protein GYA[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WCS XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6b (SRI-29789) 29215062 2.52 Å Subunit Polymerase Acidic Protein 9KU[5-hydroxy-2-[(2S)-1-{[(naphthalen-1-yl)oxy]acetyl}pyrrolidin-2-yl]-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , MN
5WCT XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6c (SRI-29775) 29215062 2.30 Å Subunit Polymerase Acidic Protein GY4[2-{(2S)-1-[(4-chlorophenyl)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , MN
5WDC XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9e (SRI-29843) 29215062 2.10 Å Subunit Polymerase Acidic Protein G2K[2-{(2S)-1-[(2-chlorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WDN XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6d (SRI-29680) 29215062 2.10 Å Subunit Polymerase Acidic Protein G1K[5-hydroxy-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxylic acid] , MN
5WDW XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10k (SRI-30027) 29215062 2.30 Å Subunit Polymerase Acidic Protein 8KU[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-{[(2S)-2,3-dihydro-1-benzofuran-2-yl]methyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide] , MN
5WE7 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-29782 To be published. 2.12 Å Subunit Polymerase Acidic Protein G3K[2-{(2R)-1-[2-(4-chlorophenoxy)-2-methylpropanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , MLT[D-MALATE], MN
5WE9 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7b (SRI-29731) 29215062 1.80 Å Subunit Polymerase Acidic Protein GY7[2-[(2S)-1-(2,6-difluorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , EDO[1,2-ETHANEDIOL], MN, MG
5WEB XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10e (SRI-30024) 29215062 2.25 Å Subunit Polymerase Acidic Protein KU5[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WEF XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (f105s mutant) in complex with inhibitor 7a (SRI-29770) 29215062 2.00 Å Subunit Polymerase Acidic Protein GY6[2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , EDO[1,2-ETHANEDIOL], MN, NA
5WEI XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 7a (SRI-29770) 29215062 2.25 Å Subunit Polymerase Acidic Protein GY6[2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WF3 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 9k (SRI-30023) 29215062 2.25 Å Subunit Polymerase Acidic Protein KU2[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4 -carboxamide] , SO4, MN
5WFM XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 10e (SRI-30024) 29215062 2.25 Å Subunit Polymerase Acidic Protein KU5[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WFW XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 10j (SRI-30026) 29215062 2.29 Å Subunit Polymerase Acidic Protein GYA[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
5WFZ XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 8e (SRI-30049) 29215062 2.35 Å Subunit Polymerase Acidic Protein KU0[2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide] , SO4, GOL, MN
5WG9 XRD Virus Influenza A virus(FluA) Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 9b (SRI-30101) 29215062 2.30 Å Subunit Polymerase Acidic Protein KU4[2-{(2S)-1-[3-(2-chlorophenyl)propanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN
6DCY XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 5-hydroxy-2-methyl-4-oxo-4h-pyran-3-carboxylic acid 30351002 2.08 Å Subunit Polymerase Acidic Protein G5V[5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid] , MN
6DCZ XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-4h-pyran-2-carboxylic acid 30351002 2.89 Å Subunit Polymerase Acidic Protein G5Y[3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid] , MN
6DZQ XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-4h-pyran-2-carboxylic acid 30351002 2.25 Å Subunit Polymerase Acidic Protein HJP[3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN
6E0Q XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid 30351002 2.35 Å Subunit Polymerase Acidic Protein HKD[4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN
6E3M XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 31536340 2.65 Å Subunit Polymerase Acidic Protein HOG[6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN
6E3N XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-6-(o-tolyl)-1,4-dihydropyridine-2-carboxylic acid 31536340 3.19 Å Subunit Polymerase Acidic Protein HNS[3-hydroxy-6-(2-methylphenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , MN
6E3O XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(2-ethylphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 31536340 3.19 Å Subunit Polymerase Acidic Protein HNY[6-(2-ethylphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , MN
6E3P XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-(1h-tetrazol-5-yl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 31536340 2.80 Å Subunit Polymerase Acidic Protein HO1[3-hydroxy-4-oxo-6-[3-(1H-tetrazol-5-yl)phenyl]-1,4-dihydropyridine-2-carboxylic acid] , MN
6E4C XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-(2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 31536340 2.35 Å Subunit Polymerase Acidic Protein HRJ[3-hydroxy-6-[2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN
6E6V XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 31536340 2.25 Å Subunit Polymerase Acidic Protein HWA[3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN
6E6W XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-(2-methyl-4-(1h-tetrazol-5-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 31536340 2.35 Å Subunit Polymerase Acidic Protein HWJ[3-hydroxy-6-[2-methyl-4-(1H-tetrazol-5-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , MN
6E6X XRD Virus Influenza A virus(FluA) The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 1-(4-(1h-tetrazol-5-yl)phenyl)-5-hydroxy-2-methylpyridin-4(1h)-one 31536340 2.50 Å Subunit Polymerase Acidic Protein HWM[5-hydroxy-2-methyl-1-[4-(1H-tetrazol-5-yl)phenyl]pyridin-4(1H)-one] , EDO[1,2-ETHANEDIOL], MN
6FS6 XRD Virus Influenza A virus(FluA) Influenza A/california/04/2009 (pH1N1) endonuclease with bound inhibitor, baloxavir acid (bxa) 29941893 2.29 Å Subunit Polymerase Acidic Protein E4Z[Baloxavir acid] , MN
6FS7 XRD Virus Influenza A virus(FluA) Influenza A/california/04/2009 (pH1N1) endonuclease with I38T mutation with bound inhibitor, baloxavir acid (bxa) 29941893 1.96 Å Subunit Polymerase Acidic Protein E4Z(Baloxavir acid) , MN
2ZNL XRD Virus Influenza A virus(FluA) Crystal structure of PA-PB1 complex form influenza virus RNAP 18660801 2.30 Å Subunit Polymerase Acidic Protein,RNAP Catalytic Subunit
2ZTT XRD Virus Influenza A virus(FluA) Crystal structure of RNAP PB1-PB2 subunits from influenza A virus 19461581 2.10 Å Subunit RNAP Catalytic Subunit,Polymerase Basic Protein 2
3A1G XRD Virus Influenza A virus(FluA) High-resolution crystal structure of RNAP PB1-PB2 subunits from influenza A virus 19461581 1.70 Å Subunit RNAP Catalytic Subunit,Polymerase Basic Protein 2
2GMO SOLUTION NMR Virus Influenza A virus(FluA) NMR-structure of an independently folded C-terminal domain of influenza polymerase subunit PB2 17310249 Subunit Polymerase Basic Protein 2
2JDQ XRD Virus Influenza A virus(FluA) C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human Importin alpha5 17310249 2.20 Å Subunit Importin Alpha-1 Subunit,Polymerase Basic Protein 2
2VQZ XRD Virus Influenza A virus(FluA) Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP 18454157 2.30 Å Subunit Polymerase Basic Protein 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE]
2VY6 XRD Virus Influenza A virus(FluA) Two domains from the C-terminal region of influenza A virus polymerase PB2 subunit 18769709 1.95 Å Subunit Polymerase Basic Protein 2
2VY7 XRD Virus Influenza A virus(FluA) The 627-domain from influenza A virus polymerase PB2 subunit 18769709 1.53 Å Subunit Polymerase Basic Protein 2
2VY8 XRD Virus Influenza A virus(FluA) The 627-domain from influenza A virus polymerase PB2 subunit with glu- 627 18769709 1.20 Å Subunit Polymerase Basic Protein 2
4NCE XRD Virus Influenza A virus(FluA) Influenza polymerase basic protein 2 (PB2) bound to 7-methyl-gtp 25019388 2.30 Å Subunit Polymerase Basic Protein 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] , 11H[9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid]
4NCM XRD Virus Influenza A virus(FluA) Influenza polymerase basic protein 2 (PB2) bound to a small-molecule inhibitor 25019388 2.82 Å Subunit Polymerase Basic Protein 2 704[N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide]
4P1U XRD Virus Influenza A virus(FluA) Influenza A (flu) virus polymerase basic protein 2 (PB2) bound to VX787, an azaindole inhibitor 25019388 2.52 Å Subunit Polymerase Basic Protein 2 21G[(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid]
4UAD XRD Virus Influenza A virus(FluA) Importin alpha 7 delta IBB in complex with influenza PB2 nuclear localization domain 25599645 2.42 Å Subunit Importin Subunit Alpha-7,Polymerase Basic Protein 2
4UAE XRD Virus Influenza A virus(FluA) Importin alpha 3 delta IBB in complex with influenza PB2 nuclear localization domain 25599645 2.70 Å Subunit Importin Subunit Alpha-3,Polymerase Basic Protein 2 SO4
4UAF XRD Virus Influenza A virus(FluA) Importin alpha 1 delta IBB in complex with influenza PB2 nuclear localization domain 25599645 1.70 Å Subunit Importin Subunit Alpha-1,Polymerase Basic Protein 2 PO4
6EUV XRD Virus Influenza A virus(FluA) Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (vx-787) 29202182 2.70 Å Subunit Polymerase Basic Protein 2 21G[(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , NI
6EUY XRD Virus Influenza A virus(FluA) Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor 29202182 3.00 Å Subunit Polymerase Basic Protein 2 BYB[(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , SO4
6TU5 XRD Virus Influenza A virus(FluA) influenza A/H7N9 polymerase core (apo) 32304664 3.33 Å RNAP Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 MG
3CM8 XRD Virus Influenza A virus(FluA) A RNAP subunit structure from virus 18615018 2.90 Å RNAP Polymerase Acidic Protein,Peptide From RNAP Catalytic Subunit
3J9B XRD Virus Influenza A virus(FluA) Electron cryo-microscopy of an RNAP 25620561 4.30 Å RNAP Polymerase,RNAP Catalytic Subunit,Polymerase Basic Protein 2
2W69 XRD Virus Influenza A virus(FluA) Influenza polymerase fragment 19194459 2.05 Å RNAP Polymerase Acidic Protein SO4, MN
3EBJ XRD Virus Influenza A virus(FluA) Crystal structure of an avian influenza virus protein 19194458 2.20 Å RNAP Polymerase Acidic Protein MG
3HW3 XRD Virus Influenza A virus(FluA) The crystal structure of avian influenza virus PA_N in complex with UMP 19587036 1.90 Å Subunit Polymerase Acidic Protein U5P[ URIDINE-5'-MONOPHOSPHATE ], MG
3HW4 XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza A virus in complex with TMP 19587036 1.90 Å Subunit Polymerase Acidic Protein TMP[THYMIDINE-5'-PHOSPHATE], MG
3HW5 EM Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pa_n in complex with AMP 19587036 1.81 Å RNAP Polymerase Acidic Protein AMP[ADENOSINE MONOPHOSPHATE], MG
3HW6 EM Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pa_n in complex with Mn 19587036 2.50 Å Subunit Polymerase Acidic Protein MN
6SYI XRD Virus Influenza A virus(FluA) C-terminal domain of influenza polymerase PA subunit and optimized small peptide inhibitor 33166574 1.60 Å RNAP Polymerase Acidic Protein,Pb1-11 PGE[TRIETHYLENE GLYCOL], EDO[1,2-ETHANEDIOL]
3CW4 XRD Virus Influenza A virus(FluA) Large C-terminal domain of influenza A virus RNA-dependent polymerase PB2 19144639 2.70 Å RNAP Polymerase Basic Protein 2
3WI0 EM Virus Influenza A virus(FluA) P453H/I471T mutant of PB2 middle domain from influenza virus a/puerto rico/8/34(H1N1) 24312396 2.00 Å RNAP Polymerase Basic Protein 2
3WI1 EM Virus Influenza A virus(FluA) P453H/I471T mutant of PB2 middle domain from influenza virus a/puerto rico/8/34(H1N1) with m7GTP 24312396 1.93 Å RNAP Polymerase Basic Protein 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE]
4ENF EM Virus Influenza A virus(FluA) Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus a/puerto rico/8/34(H1N1) 23436652 1.32 Å RNAP Polymerase Basic Protein 2 BU1[1,4-BUTANEDIOL], NO3[NITRATE ION]
4J2R EM Virus Influenza A virus(FluA) Middle domain of influenza A virus RNA-dependent polymerase PB2 24419622 2.42 Å RNAP Polymerase Basic Protein 2
4U6O EM Virus Influenza A virus(FluA) Structure of the cap-binding domain of influenza virus polymerase subunit PB2 To be published. 1.30 Å RNAP Polymerase Basic Protein 2 PO4
4EQK XRD Virus Influenza A virus(FluA) Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (H3N2) with bound m7GTP 23436652 1.95 Å Subunit Polymerase Basic Protein 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], NO3[NITRATE ION]
3KC6 XRD Virus Influenza A virus(FluA) Crystal structure of the large C-terminal domain of polymerase basic protein 2 from influenza virus A/Vietnam/1203/2004 (H5N1) 20700447 2.05 Å RNAP Polymerase PB2 EDO[1,2-ETHANEDIOL], ZN
3L56 XRD Virus Influenza A virus(FluA) Crystal structure of the large C-terminal domain of polymerase basic protein 2 from influenza virus A/Vietnam/1203/2004 (H5N1) 20700447 2.30 Å RNAP Polymerase PB2
5FMM XRD Virus Influenza A virus(FluA) Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to m7GTP 26711008 2.40 Å Subunit influenza A PB2 Subunit MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], FLC[CITRATE ANION]
5FMQ XRD Virus Influenza A virus(FluA) Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to m7GTP h32 crystal form 26711008 3.10 Å RNAP influenza A PB2 Subunit MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE]
5JUR XRD Virus Influenza A virus(FluA) PB2 bound to an azaindole inhibitor 28197322 2.93 Å Subunit Polymerase Basic Protein 2 6NS[(3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethyl-pentanoic acid]
44717 XRD Virus Influenza A virus(FluA) PB2 bound to an azaindole inhibitor 28197322 2.69 Å Subunit Polymerase Basic Protein 2 6NU[(3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-3-(1-methylcyclobutyl)propanoic acid]
5F79 XRD Virus Influenza A virus(FluA) Influenza PB2 bound to an azaindole inhibitor 28197323 2.40 Å Subunit Polymerase Basic Protein 2 4V7[N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide]
5BUH XRD Virus Influenza A virus(FluA) Influenza PB2 bound to a hydroxymethyl azaindole inhibitor 28197323 2.55 Å Subunit Polymerase Basic Protein 2 4V7[N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide]
4YD0 XRD Virus Influenza A virus(FluA) Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor 25827523 2.62 Å Subunit Polymerase Basic Protein 2 4EW[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine]
4ES5 XRD Virus Influenza A virus(FluA) Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus a/bar-headed gs/qinghai/15c/2005 (H5N1) with bound m7GTP 23436652 1.80 Å Subunit Polymerase Basic Subunit 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], SO4
5EG9 XRD Virus Influenza A virus(FluA) The cap binding site of influenza virus protein PB2 as a drug target 26894672 2.30 Å Subunit Polymerase Basic Protein 2
5WL0 XRD Virus Influenza A virus(FluA) Co-crystal structure of influenza A H3N2 PB2 (241-741) bound to vx-787 28839261 2.40 Å Subunit Polymerase Basic Protein 2 21G[(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , PEG[ DI(HYDROXYETHYL)ETHER ]
4CB4 XRD Virus Influenza A virus(FluA) Of influenza A H5N1 PB2 cap-binding domain with bound m7GTP 24134208 1.60 Å Subunit Polymerase Basic Subunit 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], CL
4CB5 XRD Virus Influenza A virus(FluA) Structure of influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f) 24134208 1.50 Å Subunit Polymerase Basic Subunit 2 93G[9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE] , CL
4CB6 XRD Virus Influenza A virus(FluA) Structure of influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11) 24134208 1.90 Å Subunit Polymerase Basic Subunit 2 29R[2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE] , IOD[IODIDE ION]
4CB7 XRD Virus Influenza A virus(FluA) Structure of influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e) 24134208 1.85 Å Subunit Polymerase Basic Subunit 2 41G[5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid] , GOL
6EUW XRD Virus Influenza A virus(FluA) Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor 29202182 1.00 Å Subunit Polymerase Basic Protein 2 BYB[(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , GOL
4YYL XRD Virus Influenza A virus(FluA) Phenolic acid derivative bound to influenza strain H1N1 polymerase subunit PA endonuclease 26252962 1.91 Å Subunit Polymerase Acidic Protein 4KN[2-(4-fluorophenoxy)-1-(2,3,4-trihydroxyphenyl)ethanone] , SO4, MN
4ZHZ XRD Virus Influenza A virus(FluA) Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region with expelling one of the metal Ions in the active site 27088785 2.50 Å Subunit Polymerase Acidic Protein 4P8[5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde] , SO4, MN
4ZI0 XRD Virus Influenza A virus(FluA) Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region without a chelation to the metal Ions in the active site 27088785 1.80 Å Subunit Polymerase Acidic Protein 4P9[4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol] , SO4, MN
4ZQQ XRD Virus Influenza A virus(FluA) Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region 27088785 1.80 Å Subunit Polymerase Acidic Protein,Polymerase Acidic Protein SO4, MN
5FDD XRD Virus Influenza A virus(FluA) Endonuclease inhibitor 1 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 27088785 2.51 Å Subunit Polymerase Acidic Protein,Polymerase Acidic Protein 4P8[5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde] , SO4, MN
5FDG XRD Virus Influenza A virus(FluA) Endonuclease inhibitor 3 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 27088785 2.10 Å Subunit Polymerase Acidic Protein 0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , SO4, MN
5I13 XRD Virus Influenza A virus(FluA) Endonuclease inhibitor 2 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 27088785 2.15 Å Subunit Polymerase Acidic Protein 4P9[4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol] , SO4, MN
5JHT XRD Virus Influenza A virus(FluA) Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region crystallized with potassium sodium tartrate 1.75 Å Subunit Polymerase Acidic Protein TLA[L(+)-TARTARIC ACID], MN
5JHV XRD Virus Influenza A virus(FluA) Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region crystallized with polyethylene glycol 8000 2.75 Å Subunit Polymerase Acidic Protein MN
6YEM XRD Virus Influenza A virus(FluA) H1N1 2009 PA endonuclease in complex with quambalarine b 32883638 2.50 Å RNAP Polymerase Acidic Protein,Polymerase Acidic Protein OOH[3,5,6,8-tetrakis(oxidanyl)-2-pentanoyl-naphthalene-1,4-dione] , MN, CL, MG
4E5I XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan bound to compound 4 22876176 2.94 Å Subunit Polymerase Protein Pa 0N9[5-hydroxy-2-(1-methyl-1H-imidazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , SO4, MN
4E5J XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan bound to compound 5 22876176 2.35 Å Subunit Polymerase Protein Pa 581[2-[3-(acetylamino)phenyl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , SO4, MN
4E5L XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan bound to compound 6 22876176 2.47 Å Subunit Polymerase Protein Pa DBH[2,3-DIHYDROXY-BENZOIC ACID] , SO4, MN
4E5H XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan bound to compound 3 22876176 2.16 Å Subunit Polymerase Protein Pa 0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , SO4, MN
4E5E XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan apo 22876176 2.05 Å Subunit Polymerase Protein Pa SO4, MN
4E5F XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan bound to compound 1 22876176 2.39 Å Subunit Polymerase Protein Pa 0N7[2-hydroxyisoquinoline-1,3(2H,4H)-dione] , SO4, MN
4E5G XRD Virus Influenza A virus(FluA) Crystal structure of avian influenza virus pan bound to compound 2 22876176 2.65 Å Subunit Polymerase Protein Pa XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID] , SO4, MN
5EG8 XRD Virus Influenza A virus(FluA) The cap binding site of influenza virus protein PB2 as a drug target 26894672 1.54 Å Subunit Polymerase Basic Protein 2 SCN[THIOCYANATE ION]
5EG7 XRD Virus Influenza A virus(FluA) The cap binding site of influenza virus protein PB2 as a drug target 26894672 1.40 Å Subunit Polymerase Basic Protein 2 MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] , GOL
6YA5 XRD Virus Influenza A virus(FluA) 2009 H1N1 PA endonuclease in complex with Lu2 32883638 2.00 Å Subunit Polymerase Acidic Protein LU2[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one] , PGE[TRIETHYLENE GLYCOL], PEG[ DI(HYDROXYETHYL)ETHER ], SO4, DMS[DIMETHYL SULFOXIDE], MN, MG
7K0W XRD Virus Influenza A virus(FluA) The crystal structure of the 2009/H1N1/california PA endonuclease (construct with truncated loop 51-72) in complex with baloxavir acid To be published. 2.09 Å Subunit Polymerase Acidic Protein E4Z ??Baloxavir acid?? SO4 ??SULFATE ION?? MN ??MANGANESE(II) ION??
4W9S XRD Virus Influenza A virus(FluA) 2-(4-(1h-tetrazol-5-yl)phenyl)-5-hydroxypyrimidin-4(3h)-one bound to influenza 2009 H1N1 endonuclease 25225968 1.80 Å Subunit Polymerase Acidic Protein 3K1??5-hydroxy-2-[4-(1H-tetrazol-5-yl)phenyl]pyrimidin-4(3H)-one?? SO4 MN
4MK1 XRD Virus Influenza A virus(FluA) 5-bromopyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease 23978130 1.85 Å Subunit Polymerase PA 27Y ??5-bromo-3-hydroxypyridin-2(1H)-one?? SO4 EDO ??1,2-ETHANEDIOL?? MN
4MK2 XRD Virus Influenza A virus(FluA) 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile bound to influenza 2009 pH1N1 endonuclease 23978130 1.85 Å Subunit Polymerase PA 28B ??3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile?? SO4 EDO ??1,2-ETHANEDIOL?? MN
4MK5 XRD Virus Influenza A virus(FluA) 6-(3-methoxyphenyl)pyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease 23978130 1.90 Å Subunit Polymerase PA 28A ??3-hydroxy-6-(3-methoxyphenyl)pyridin-2(5H)-one?? SO4 EDO ??1,2-ETHANEDIOL?? MN
3R2V XRD Virus Influenza A virus(FluA) Crystal structure of polymerase basic protein 2 e538-r753 from influenza A virus a/yokohama/2017/03 H3N2 21904043 1.30 Å Subunit PB2 C-terminal Subunit IOD??IODIDE ION?? BO3??BORIC ACID??
6S5V XRD Virus Influenza A virus(FluA) Crystal structure of the cap-midlink region of the H5N1 influenza A virus polymerase in complex with a cap-domain binding analogue 31647875 1.35 Å Subunit Polymerase Basic Protein 2 KWN??(1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid?? GOL??GLYCEROL?? K
3KHW XRD Virus Influenza A virus(FluA) Crystal structure of the large C-terminal domain of polymerase basic protein 2 from influenza virus a/mexico/indre4487/2009(H1N1) 20700447 2.10 Å Subunit Polymerase PB2 GOL ??GLYCEROL??
5CXR XRD Virus Influenza A virus(FluA) Influenza endonuclease complexed with 4-bromopyrazole 26870381 2.00 Å Subunit Endonuclease BYZ??4-bromo-1H-pyrazole??(protein binder) SO4 EDO??1,2-ETHANEDIOL?? MN
4P9A XRD Virus Influenza A virus(FluA) X-ray crystal structure of PA protein from influenza strain h7n9 25089892 2.20 Å Subunit Polymerase PA