| 7YOT |
EM |
Virus |
Avian orthoavulavirus 1 |
Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus |
|
3.00 Å |
RNAP |
NDV P protein,RNA-directed RNA polymerase L |
|
| 7YOU |
EM |
Virus |
Avian orthoavulavirus 1 |
Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus |
|
3.41 Å |
RNAP |
RNA-directed RNA polymerase L,NDV P protein |
|
| 7YOV |
EM |
Virus |
Avian orthoavulavirus 1 |
Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus |
|
3.25 Å |
RNAP |
NDV P protein,RNA-directed RNA polymerase L |
|
| 6PNS |
EM |
Virus |
Bluetongue virus(BTV) |
In situ structure of BTV RNAP in BTV virion |
31350350 |
3.70 Å |
RNAP |
RNAP,inner Core Structural Protein VP3 |
|
| 6PO2 |
EM |
Virus |
Bluetongue virus(BTV) |
In situ structure of BTV RNAP in BTV core |
31350350 |
3.60 Å |
RNAP |
RNAP,inner Core Structural Protein VP3 |
|
| 3JB6 |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structures of the segmented genome and RNAP complex inside a dsRNA virus |
26503045 |
3.30 Å |
RNAP |
RNAP,VP4,VP1 CSP |
DCT[ 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE ] |
| 3JB7 |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structures of the segmented genome and RNAP complex inside a dsRNA virus |
26503045 |
4.00 Å |
RNAP |
RNAP,VP4,VP1 CSP |
DCT[ 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE ], CTP[ CYTIDINE-5'-TRIPHOSPHATE ] |
| 5H0R |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
RNAP ,VP4,dsRNA |
27914893 |
3.90 Å |
RNAP |
RNAP,VP9 |
|
| 6TY8 |
EM |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structure of bmcpv RNAP at quiescent state |
31695188 |
3.00 Å |
RNAP |
RNAP,VP4 |
GTA[ P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE ] |
| 6TY9 |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structure of bmcpv RNAP at initiation state |
31695188 |
2.90 Å |
IC |
RNAP,VP5 |
MG |
| 6TZ0 |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structure of bmcpv RNAP at abortive state |
31695188 |
2.80 Å |
IC |
RNAP,VP6 |
|
| 6TZ1 |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structure of bmcpv RNAP at early-elongation state |
31695188 |
3.40 Å |
EC |
RNAP,VP7 |
|
| 6TZ2 |
XRD |
Virus |
Bombyx mori cypovirus(BmCPV) |
In situ structure of bmcpv RNAP at elongation state |
31695188 |
3.50 Å |
EC |
RNAP,VP8 |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], UTP[ URIDINE 5'-TRIPHOSPHATE ],MG |
| 4WFX |
XRD |
Virus |
Bos taurus |
Coxsackievirus B3 polymerase - f232l mutant - nacl crystal form |
25320316 |
1.81 Å |
RNAP |
RNAP |
NA |
| 4AU6 |
XRD |
Virus |
Bovine rotavirus(BoRV) |
Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles |
23089332 |
6.00 Å |
RNAP |
RNAP VP1 |
|
| 1S48 |
XRD |
Virus |
Bovine viral diarrhea virus(BVDV) |
Crystal structure of RNAP construct 1 (residues 71-679) from BVDV |
15070734 |
3.00 Å |
RNAP |
RNAP |
|
| 1S49 |
XRD |
Virus |
Bovine viral diarrhea virus(BVDV) |
Crystal structure of RNAP construct 1 (residues 71-679) from bovine viral diarrhea virus complexed with GTP |
15070734 |
3.00 Å |
RNAP |
RNAP |
DCT[ 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE ] |
| 1S4F |
XRD |
Virus |
Bovine viral diarrhea virus(BVDV) |
Crystal structure of RNAP construct 2 from bovine viral diarrhea virus (BVDV) |
15070734 |
3.00 Å |
RNAP |
RNAP |
|
| 2CJQ |
XRD |
Virus |
Bovine viral diarrhea virus(BVDV) |
Bovine viral diarrhea virus CP7-R12 RNAP |
16843892 |
2.60 Å |
RNAP |
RNAP |
|
| 5YF5 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-694) |
30239956 |
2.49 Å |
RNAP |
RDRP |
|
| 5YF6 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-682) |
30239956 |
2.10 Å |
RNAP |
RDRP |
|
| 5YF7 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-672) |
30239956 |
2.27 Å |
RNAP |
RDRP |
|
| 5YF8 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-672, Y471A-E472A mutant) |
30239956 |
3.40 Å |
RNAP |
RDRP |
ACT[ ACETATE ION ] |
| 6AE4 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-694, Y471A mutant) |
30239956 |
2.95 Å |
RNAP |
RDRP |
|
| 6AE5 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-672, Y471A mutant, form 1) |
30239956 |
2.75 Å |
RNAP |
RDRP |
|
| 6AE6 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-672, Y471A mutant, form 2) |
30239956 |
3.86 Å |
RNAP |
RDRP |
ACT[ ACETATE ION ] |
| 6AE7 |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystals structure of Classificationical swine fever virus NS5B (residues 1-672, E472A mutant) |
30239956 |
3.80 Å |
RNAP |
RDRP |
ACT[ ACETATE ION ] |
| 5Y6R |
XRD |
Virus |
Classificationical swine fever virus(CSFV) |
Crystal structure of CSFV NS5B |
29720518 |
3.01 Å |
RNAP |
RDRP |
SO4 GOL |
| 5Y6Z |
XRD |
Virus |
Coxsackievirus A16 (CVA16) |
Crystal structure of the coxsackievirus A16 polymerase elongation complex |
29164396 |
2.50 Å |
EC |
RNAP |
PO4 GOL MG |
| 3DDK |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 3D pol RNAP |
18632862 |
2.25 Å |
RNAP |
RNAP |
SO4, NA |
| 4K4X |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase elongation complex (r2_form), RNA |
23667424 |
2.37 Å |
EC |
RNAP |
GOL, MG |
| 4K4Y |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase elongation complex (r2+1_form) |
23667424 |
2.72 Å |
EC |
RNAP |
DCT[ 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE ] , GOL, ACT[ ACETATE ION ] |
| 4K4Z |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase elongation complex (r2_mg_form) |
23667424 |
2.17 Å |
EC |
RNAP |
MG |
| 4Y34 |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Crystal structure of coxsackievirus B3 3D polymerase in complex with GPC-N143 |
25799064 |
2.70 Å |
RNAP |
RNAP |
45Z[ 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile)] , SO4,GOL |
| 4ZP6 |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - F364A mutant |
27137934 |
1.65 Å |
RNAP |
RNAP |
SO4 |
| 4ZP7 |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - F364V mutant |
27137934 |
1.90 Å |
RNAP |
RNAP |
|
| 4ZP8 |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - F364L mutant |
27137934 |
1.89 Å |
RNAP |
RNAP |
|
| 4ZP9 |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - F364I mutant |
27137934 |
1.80 Å |
RNAP |
RNAP |
|
| 4ZPA |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - F364Y mutant |
27137934 |
2.67 Å |
RNAP |
RNAP |
SO4 |
| 4ZPB |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - F364W mutant |
27137934 |
1.80 Å |
RNAP |
RNAP |
|
| 4ZPC |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - A341G mutant |
27137934 |
1.59 Å |
RNAP |
RNAP |
|
| 4ZPD |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - A345V mutant |
27137934 |
1.80 Å |
RNAP |
RNAP |
|
| 3CDU |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Crystal structure of coxsackievirus B3 RNAP (3D pol) in complex with a pyrophosphate |
18632861 |
2.10 Å |
RNAP |
RNAP |
POP[ PYROPHOSPHATE 2- ], SO4,GOL, ACT[ ACETATE ION ], CL |
| 3CDW |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Crystal structure of coxsackievirus B3 RNAP (3D pol) in complex with protein primer VPG and a pyrophosphate |
18632861 |
2.50 Å |
RNAP |
RNAP, Protein 3b |
POP[ PYROPHOSPHATE 2- ], GOL, ACT[ACETATE ION], CL |
| 4WFY |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 polymerase - f232l mutant - amso4 crystal form |
25320316 |
2.06 Å |
RNAP |
RNAP |
SO4, GOL |
| 4WFZ |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Coxsackievirus B3 3D pol RNAP - nacl crystal form |
25320316 |
1.80 Å |
RNAP |
RNAP |
NA |
| 4Y2A |
XRD |
Virus |
Coxsackievirus B3 (CVB3) |
Crystal structure of coxsackie virus B3 3D polymerase in complex with gpc-n114 inhibitor |
25799064 |
2.90 Å |
RNAP |
RNAP |
1FS[ 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile) ] , SO4, GOL |
| 3PT2 |
XRD |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
Structure of a viral OTU domain protease bound to ubiquitin |
21245344 |
2.50 Å |
Subunit |
RNAP,Ubiquitin B |
SO4,3CN[ 3-AMINOPROPANE ],ACT[ ACETATE ION ] |
| 3PSE |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
Structure of a viral OTU domain protease bound to interferon-stimulated gene 15 (LSG15) |
21245344 |
2.30 Å |
Subunit |
RNAP,Ubiquitin-Like Protein LSG15 |
GOL,3CN[ 3-AMINOPROPANE ] |
| 4HXD |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
Diversity of ubiquitin and LSG15 specificity amongst nairoviruses viral ovarian tumor domain proteases |
23345508 |
2.85 Å |
Subunit |
Polyubiquitin-C,RNAP L |
SO4, 3CN[ 3-AMINOPROPANE ] |
| 3PHU |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
OTU domain of crimean congo hemorrhagic fever virus |
21266548 |
2.20 Å |
Subunit |
RNAP L |
GOL |
| 3PHW |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
OTU domain of crimean congo hemorrhagic fever virus in complex with ubiquitin |
21266548 |
2.00 Å |
Subunit |
RNAP L,Ubiquitin-40s Ribosomal Protein S27a |
NEH[ ETHANAMINE ] |
| 3PHX |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
Tu domain of crimean congo hemorrhagic fever virus in complex with LSG15 |
21266548 |
1.60 Å |
Subunit |
RNAP L,Ubiquitin-Like Protein LSG15 |
ACY[ ACETIC ACID ],NEH[ ETHANAMINE ], ZN |
| 3ZNH |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
Rimean congo hemorrhagic fever virus OTU domain in complex with ubiquitin-propargyl. |
23387960 |
2.30 Å |
Subunit |
Ubiquitin Thioesterase,Polyubiquitin-B |
|
| 5V5G |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
OTU protease of crimean congo hemorrhagic fever virus bound to ubiquitin variant CC.4 |
28542609 |
2.10 Å |
Subunit |
RNAP L,Ubiquitin Variant CC.4 |
EDO[ 1,2-ETHANEDIOL ],NA |
| 5V5H |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
OTU protease of crimean congo hemorrhagic fever virus bound to ubiquitin variant CC.2 |
28542609 |
1.50 Å |
Subunit |
RNAP L,Ubiquitin Variant CC.2 |
EPE[ 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID ], ZN, NA |
| 5V5I |
EM |
Virus |
Crimean-Congo hemorrhagic fever orthonairovirus(CCHFV) |
OTU protease of crimean congo hemorrhagic fever virus bound to ubiquitin variant CC.1 |
To be published. |
2.20 Å |
Subunit |
RNAP L,Ubiquitin Variant CC.1 |
|
| 5K5M |
XRD |
Virus |
Dengue virus(DENV) |
Co-crystal structure of dengue virus serotype 2 RNAP with compound 27 |
27500641 |
2.01 Å |
RNAP |
RNAP (NS5) |
68T[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide ] , MES[ 2-(N-MORPHOLINO)-ETHANESULFONIC ACID ], ZN |
| 2J7U |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus NS5 RNAP domain |
17301146 |
1.85 Å |
RNAP |
RNAP (NS5) |
PGE[TRIETHYLENE GLYCOL], ZN, CL, MG |
| 2J7W |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus NS5 RNAP domain complexed with 3' dGTP |
17301146 |
2.60 Å |
RNAP |
RNAP (NS5) |
GTP[ GUANOSINE-5'-TRIPHOSPHATE ], PEG[ DI(HYDROXYETHYL)ETHER ],ZN |
| 4C11 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus RNAP with residues from the NS5 linker region |
24025331 |
2.60 Å |
RNAP |
RNAP (NS5) |
ZN |
| 4HHJ |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP |
23408636 |
1.79 Å |
RNAP |
RNAP (NS5) |
P6G[ HEXAETHYLENE GLYCOL ], PEG[ DI(HYDROXYETHYL)ETHER ], ZN |
| 5DTO |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus full length NS5 complexed with viral cap 0-RNA and SAH |
26578813 |
2.60 Å |
RNAP |
RNAP (NS5) |
M7G[ 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE ], SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], ACT[ ACETATE ION ], ZN,MG |
| 5F3T |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to JF-31-MG46 |
26872970 |
2.05 Å |
RNAP |
RNAP (NS5) |
5UH[ 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid ], ZN |
| 5F3Z |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to PC-79-SH52 |
26872970 |
2.00 Å |
RNAP |
RNAP (NS5) |
5V5[ 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid ], ZN |
| 5F41 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to FD-83-KI26 |
26872970 |
2.00 Å |
RNAP |
RNAP (NS5) |
5V6[ 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid ], ZN |
| 5HMW |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 5 |
26984786 |
2.15 Å |
RNAP |
RNAP (NS5) |
LNW[ 2,2'-biphenyl-3,5-diyldiacetic acid ] , ZN |
| 5HMX |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 10 |
26984786 |
2.40 Å |
RNAP |
RNAP (NS5) |
LNX[ 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid ],ZN |
| 5HMY |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 15 |
26984786 |
2.10 Å |
RNAP |
RNAP (NS5) |
LNY[ 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid ], ZN |
| 5HMZ |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 23 |
26984786 |
1.99 Å |
RNAP |
RNAP (NS5) |
LNZ[ 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide ] ,ZN |
| 5HN0 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 4 |
26984786 |
2.05 Å |
RNAP |
RNAP (NS5) |
LNN[ (6-hydroxybiphenyl-3-yl)acetic acid ] ,ZN |
| 5I3P |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 27 |
27500641 |
2.45 Å |
RNAP |
RNAP (NS5) |
68T[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide ] , ZN |
| 5I3Q |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to compound 29 |
27500641 |
1.88 Å |
RNAP |
RNAP (NS5) |
68E[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide ],ZN |
| 5IQ6 |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue virus serotype 3 RNAP bound to HEE1-2TYR, a new pyridobenzothizole inhibitor |
27649989 |
3.00 Å |
RNAP |
RNAP (NS5) |
6CJ[ N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine ] , ZN |
| 5JJR |
XRD |
Virus |
Dengue virus(DENV) |
Dengue 3 NS5 protein with compound 29 |
27500641 |
1.99 Å |
RNAP |
RNAP (NS5) |
68E[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide ] ,SAH[ S-ADENOSYL-L-HOMOCYSTEINE ]、PEG[ DI(HYDROXYETHYL)ETHER ],EDO[ 1,2-ETHANEDIOL ], ZN,MG |
| 5JJS |
XRD |
Virus |
Dengue virus(DENV) |
Dengue 3 NS5 protein with compound 27 |
27500641 |
1.65 Å |
RNAP |
RNAP (NS5) |
6L2[ 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-{[(1R,3R)-3-methoxycyclohexyl]sulfonyl}benzamide ] 、 SAH[ S-ADENOSYL-L-HOMOCYSTEINE ]、PEG[ DI(HYDROXYETHYL)ETHER ]、EDO[ 1,2-ETHANEDIOL ]、 ZN、 MG |
| 6H80 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue-RDRP3-inhibitor complex co-crystallisation |
30602529 |
2.30 Å |
RNAP |
RNAP (NS5) |
5V5[ 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid ] ,PEG[ DI(HYDROXYETHYL)ETHER ],ZN |
| 6H9R |
XRD |
Virus |
Dengue virus(DENV) |
Dengue-RDRP3-inhibitor complex soaking |
30602529 |
2.40 Å |
RNAP |
RNAP (NS5) |
5V5[ 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid ] ,PEG[ DI(HYDROXYETHYL)ETHER ], ZN |
| 3VWS |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to NITD-107 |
23408636 |
2.10 Å |
RNAP |
RNAP (NS5) |
VWS[ 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid ], PEG[ DI(HYDROXYETHYL)ETHER ], ZN |
| 1L9K |
XRD |
Virus |
Dengue virus(DENV) |
Dengue methyltransferase |
12032088 |
2.40 Å |
Subunit |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4 |
| 1R6A |
XRD |
Virus |
Dengue virus(DENV) |
Structure of the dengue virus 2'o methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate |
15152003 |
2.60 Å |
Subunit |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],RVP[ RIBAVIRIN MONOPHOSPHATE ], SO4 |
| 5HHG |
XRD |
Virus |
Dengue virus(DENV) |
Mouse Importin alpha: dengue 2 NS5 C-terminal NLS peptide complex |
27622521 |
2.20 Å |
Subunit |
RNAP (NS5) ,Importin Subunit Alpha-1 |
|
| 6IZZ |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 3 NS5, bound with rk-0404678 |
31738758 |
1.97 Å |
RNAP |
RNAP (NS5) |
B5C[ 2-oxo-2H-1,3-benzoxathiol-5-yl acetate ] , ZN |
| 6J00 |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 3 NS5 |
31738758 |
2.14 Å |
RNAP |
RNAP (NS5) |
ZN |
| 6XD1 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to NITD-640 |
32907977 |
1.95 Å |
RNAP |
RNAP (NS5) |
V0J[ (2R)-4-(butyl{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}carbamoyl)-1-(2,2-diphenylpropanoyl)piperazine-2-carboxylic acid ], ZN |
| 3EVG |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue-2 virus methyltransferase complexed with s-adenosyl-l-homocysteine |
19101564 |
2.20 Å |
Subunit |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4 |
| 6KR2 |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue virus nonstructural protein NS5 (form 1) |
32357182 |
3.06 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],ZN |
| 6KR3 |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of dengue virus nonstructural protein NS5 (form 2) |
32357182 |
2.93 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],IOD[ IODIDE ION ],GOL, ZN |
| 6IZX |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 2 NS5, bound with rk-0404678 |
31738758 |
2.43 Å |
RNAP |
RNAP (NS5) |
B5C[ 2-oxo-2H-1,3-benzoxathiol-5-yl acetate ],ZN、CO |
| 6IZY |
XRD |
Virus |
Dengue virus(DENV) |
The RNAP domain of dengue 2 NS5 |
31738758 |
2.11 Å |
Subunit |
RNAP (NS5) |
ZN,CO |
| 6XD0 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue serotype 3 RNAP bound to NITD-434 |
32907977 |
2.01 Å |
RNAP |
RNAP (NS5) |
V0M[ 2-[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid ],PEG [ DI(HYDROXYETHYL)ETHER ],GOL ,MN |
| 3P8Z |
XRD |
Virus |
Dengue virus(DENV) |
Dengue methyltransferase bound to a sam-based inhibitor |
21147775 |
1.70 Å |
Subunit |
RNAP (NS5) |
36A??(S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid?? SAH??S-ADENOSYL-L-HOMOCYSTEINE?? |
| 3P97 |
XRD |
Virus |
Dengue virus(DENV) |
Dengue 3 NS5 methyltransferase bound to the substrate s-adenosyl methionine |
21147775 |
1.70 Å |
Subunit |
RNAP (NS5) |
SAM[ S-ADENOSYLMETHIONINE ] |
| 5CCV |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of full-length NS5 from dengue virus type 3 |
26895240 |
3.60 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ] , ZN |
| 4V0Q |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus full length NS5 complexed with sah |
25775415 |
2.30 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],GOL, ZN, ACT[ ACETATE ION ] |
| 4V0R |
XRD |
Virus |
Dengue virus(DENV) |
Dengue virus full length NS5 complexed with GTP and sah |
25775415 |
2.40 Å |
RNAP |
RNAP (NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ] , GTP, GOL[ GLYCEROL ],ZN, FMT [FORMIC ACID], MG |
| 3EVG |
XRD |
Virus |
Dengue virus(DENV) |
Crystal structure of Dengue-2 virus methyltransferase complexed with S-adenosyl-L-homocysteine |
19101564 |
2.20Å |
Subunit |
RNAP NS5 |
SAH [ S-ADENOSYL-L-HOMOCYSTEINE ] SO4 |
| 7YER |
EM |
Virus |
Ebola virus |
The structure of EBOV L-VP35 complex |
36171293 |
3.00 Å |
Domain |
RNA-directed RNA polymerase L,Polymerase cofactor VP35 |
ZN |
| 7YES |
EM |
Virus |
Ebola virus |
The structure of EBOV L-VP35-RNA complex (state2) |
36171293 |
3.40 Å |
RNAP |
RNA-directed RNA polymerase L,VP35 of EBOV L-VP35 complex |
ZN |
| 7YET |
EM |
Virus |
Ebola virus |
The structure of EBOV L-VP35 in complex with suramin |
36171293 |
3.30 Å |
Domain |
RNA-directed RNA polymerase L,Polymerase cofactor VP35 |
SVR[8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID] |
| 6LSH |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6M form) |
32451382 |
2.23 Å |
EC |
RNAP |
SO4[ SULFATE ION ], ZN |
| 6LSG |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of the enterovirus 71 polymerase elongation complex (C0S6M form) |
32451382 |
2.14 Å |
EC |
RNAP |
SO4[ SULFATE ION ], ZN |
| 6LSF |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form) |
32451382 |
2.15 Å |
EC |
RNAP |
SO4[ SULFATE ION ], ZN |
| 6LSE |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of the enterovirus 71 polymerase elongation complex (C3S6A/C3S6B form) |
32451382 |
2.25 Å |
EC |
RNAP |
POP[ PYROPHOSPHATE 2- ], SO4, ZN |
| 5F8G |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C1S1 form) |
27339134 |
2.78 Å |
EC |
RNAP |
ZN |
| 6KWQ |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of enterovirus 71 polymerase elongation complex (native form) |
31863580 |
1.76 Å |
EC |
RNAP |
PEG[ DI(HYDROXYETHYL)ETHER ], GOL,ZN, MG |
| 6KWR |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form) |
31863580 |
2.50 Å |
EC |
RNAP |
DCT[ 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE ], ZN,MG |
| 3N6L |
XRD |
Virus |
Enterovirus(EV) |
The crystal structure of RNAP of EV71 virus |
21203964 |
2.60 Å |
RNAP |
RNAP |
NI |
| 3N6M |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of EV71 RDRP in complex with GTP |
21203964 |
2.50 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ], NI |
| 3N6N |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of EV71 RDRP in complex with br-UTP |
21203964 |
2.90 Å |
RNAP |
RNAP |
BUP[ 5-bromouridine 5'-(tetrahydrogen triphosphate) ], NI |
| 5XE0 |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of ev-d68-3D pol in complex with GTP |
28659472 |
2.30 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ] |
| 5ZIT |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of human enterovirus D68 RDRP in complex with NADPH |
32353513 |
3.20 Å |
RNAP |
RDRP |
NDP[ NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE ], PEG[ DI(HYDROXYETHYL)ETHER ] |
| 6L4R |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of enterovirus D68 RDRP |
32353513 |
2.15 Å |
RNAP |
RDRP |
|
| 5F8H |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C1S1/2 form) |
27339134 |
2.45 Å |
EC |
RDRP |
SO4, ZN, MG |
| 5F8I |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C1S2/3 form) |
27339134 |
2.50 Å |
EC |
RDRP |
CTP[ CYTIDINE-5'-TRIPHOSPHATE ], GOL, SO4, ZN, MG |
| 5F8J |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C1S4 form) |
27339134 |
2.67 Å |
EC |
RDRP |
POP[ PYROPHOSPHATE 2- ], SO4, GOL, ZN, MG |
| 5F8L |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C3S1 form) |
27339134 |
2.81 Å |
EC |
RDRP |
ZN |
| 5F8M |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C3S4/5 form) |
27339134 |
2.83 Å |
EC |
RDRP |
POP[ PYROPHOSPHATE 2- ], SO4, GOL, ZN, MG |
| 5F8N |
XRD |
Virus |
Enterovirus(EV) |
Enterovirus 71 polymerase elongation complex (C3S6 form) |
27339134 |
2.48 Å |
EC |
RDRP |
POP[ PYROPHOSPHATE 2- ], SO4, GOL, ZN |
| 4IKA |
XRD |
Virus |
Enterovirus(EV) |
Crystal structure of EV71 3D pol-VPG |
23487447 |
2.70 Å |
RNAP |
RDRP |
NI |
| 8DH0 |
XRD |
Virus |
Escherichia phage T7 |
T7 RNA polymerase elongation complex with unnatural base dDs |
36635281 |
2.90 Å |
EC |
T7 RNA polymerase |
GOL[GLYCEROL] |
| 8DH4 |
XRD |
Virus |
Escherichia phage T7 |
T7 RNA polymerase elongation complex with unnatural base dPa-DsTP pair |
36635281 |
2.80 Å |
EC |
T7 RNA polymerase |
S96[(7P)-3-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-7-(thiophen-2-yl)-3H-imidazo[4,5-b]pyridine],MG |
| 8DH2 |
XRD |
Virus |
Escherichia phage T7 |
T7 RNA polymerase elongation complex with unnatural base dDs-ATP mismatch |
36635281 |
2.90 Å |
EC |
T7 RNA polymerase |
3PO[TRIPHOSPHATE],GOL[GLYCEROL],MG |
| 8DH3 |
XRD |
Virus |
Escherichia phage T7 |
T7 RNA polymerase elongation complex with unnatural base dPa-DsTP pair |
36635281 |
3.00 Å |
EC |
T7 RNA polymerase |
|
| 8DH1 |
XRD |
Virus |
Escherichia phage T7 |
T7 RNA polymerase elongation complex with unnatural base dDs-PaTP pair |
36635281 |
2.65 Å |
EC |
T7 RNA polymerase |
S8L[1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-1H-pyrrole-2-carbaldehyde],GOL[GLYCEROL],MG |
| 8DH5 |
XRD |
Virus |
Escherichia phage T7 |
T7 RNA polymerase elongation complex with unnatural base dPa-ATP mismatch |
36635281 |
2.85 Å |
EC |
T7 RNA polymerase |
ATP[ADENOSINE-5'-TRIPHOSPHATE],MG |
| 1ARO |
XRD |
Virus |
Escherichia phage T7(T7) |
T7 RNAP complexed with T7 lysozyme |
9670025 |
2.80 Å |
RNAP |
T7 RNAP,T7 Lysozyme |
HG |
| 1CEZ |
XRD |
Virus |
Escherichia phage T7(T7) |
Crystal structure of a T7 RNAP-T7 promoter complex |
10331394 |
2.40 Å |
IC |
T7 RNAP |
|
| 1H38 |
XRD |
Virus |
Escherichia phage T7(T7) |
Structure of a T7 RNAP elongation complex at 2.9 angstrom resolution |
12422209 |
2.90 Å |
EC |
T7 RNAP |
|
| 1MSW |
XRD |
Virus |
Escherichia phage T7(T7) |
Structural basis for the transition from initiation to elongation transcription in T7 RNAP |
12242451 |
2.10 Å |
IC-EC |
T7 RNAP |
|
| 1S0V |
XRD |
Virus |
Escherichia phage T7(T7) |
Structural basis for substrate selection by T7 RNAP |
15016373 |
3.20 Å |
EC |
T7 RNAP |
APC[ Diphosphomethylphosphonic Acid Adenosyl Ester ], MG |
| 1S76 |
XRD |
Virus |
Escherichia phage T7(T7) |
T7 RNAP alpha beta methylene ATP elongation complex |
15016374 |
2.88 Å |
EC |
T7 RNAP |
APC[ Diphosphomethylphosphonic Acid Adenosyl Ester ], MG |
| 1S77 |
XRD |
Virus |
Escherichia phage T7(T7) |
T7 RNAP product pyrophosphate elongation complex |
15016374 |
2.69 Å |
EC |
T7 RNAP |
POP[ PYROPHOSPHATE 2- ],, MG |
| 2PI4 |
XRD |
Virus |
Escherichia phage T7(T7) |
T7 RNAP complexed with a phi10 protein and initiating GTPs. |
17512007 |
2.50 Å |
IC |
T7 RNAP |
GH3[ 3'-deoxy-guanosine-5'-triphosphate ], MG |
| 2PI5 |
XRD |
Virus |
Escherichia phage T7(T7) |
T7 RNAP complexed with a phi10 promoter |
17512007 |
2.90 Å |
IC |
T7 RNAP |
|
| 3E2E |
XRD |
Virus |
Escherichia phage T7(T7) |
Crystal structure of an intermediate complex of T7 RNAP and 7nt of RNA |
18948533 |
3.00 Å |
IC,EC |
T7 RNAP |
|
| 3E3J |
XRD |
Virus |
Escherichia phage T7(T7) |
Crystal structure of an intermediate complex of T7 RNAP and 8nt of RNA |
18948533 |
6.70 Å |
IC,EC |
T7 RNAP |
|
| 4RNP |
XRD |
Virus |
Escherichia phage T7(T7) |
Bacteriophage T7 RNAP, high salt crystal form, low temperature data, alpha-carbons only |
7688864 |
3.00 Å |
RNAP |
T7 RNAP |
|
| 2PO4 |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of polymerase domain of the bacteriophage N4 virion RNAP |
18362338 |
2.00 Å |
RNAP |
N4 Virion RNAP |
|
| 3C2P |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the N4 mini-vRNAP P1 promoter complex |
19061645 |
2.00 Å |
IC |
N4 Virion RNAP |
|
| 3C3L |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the N4 mini-vRNAP P2 promoter complex |
19061645 |
2.40 Å |
IC |
N4 Virion RNAP |
|
| 3C46 |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the N4 mini-vRNAP P2 _7a promoter complex soaked with mgcl2 |
19061645 |
2.00Å |
RNAP |
N4 Virion RNAP |
|
| 3Q0A |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the transcription initiation complex of the N4 mini-vRNAP with P2 promoter: mismatch complex |
21321236 |
2.69 Å |
IC |
N4 Virion RNAP |
GTP[ Guanosine-5'-Triphosphate ], PO4 [ PHOSPHATE ION ] |
| 3Q22 |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the N4 mini-vRNAP and P2 _7a promoter transcription initiation complex with GTP and magnesium: substrate complex I |
21321236 |
2.11 Å |
IC |
N4 Virion RNAP |
GTP[ Guanosine-5'-Triphosphate ], 2HP[ DIHYDROGENPHOSPHATE ION ], MG |
| 3Q23 |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the N4 mini-vRNAP and P2 _7a promoter transcription initiation complex with GMPCPP andMn2+: sustrate complex II |
21321236 |
1.80 Å |
IC |
N4 Virion RNAP |
G2P[ PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER ],2HP[ DIHYDROGENPHOSPHATE ION ], MN |
| 3Q24 |
XRD |
Virus |
Escherichia virus N4(N4) |
X-ray crystal structure of the N4 mini-vRNAP and P2 _7a promoter transcription initiation complex with PPPGPG and pyrophosphate: product complex |
21321236 |
1.81 Å |
IC |
N4 Virion RNAP |
GTP[ Guanosine-5'-Triphosphate ], G[GUANOSINE-5'-MONOPHOSPHATE], POP[PYROPHOSPHATE 2- ], 2HP[ DIHYDROGENPHOSPHATE ION ] |
| 4FF1 |
XRD |
Virus |
Escherichia virus N4(N4) |
N4 mini-vRNAP transcription initiation complex, 1 min after soaking GTP, ATP and MN |
23235152 |
2.47 Å |
IC |
N4 Virion RNAP |
PO4 |
| 4FF2 |
XRD |
Virus |
Escherichia virus N4(N4) |
N4 mini-vRNAP transcription initiation complex, 2 min after soaking GTP, ATP and MN |
23235152 |
2.00 Å |
IC |
N4 Virion RNAP |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], GTP[ GUANOSINE-5'-MONOPHOSPHATE ], PO4[ PHOSPHATE ION ], MN |
| 4FF3 |
XRD |
Virus |
Escherichia virus N4(N4) |
N4 mini-vRNAP transcription initiation complex, 3 min after soaking GTP, ATP and MN |
23235152 |
2.00 Å |
IC |
N4 Virion RNAP |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], 5GP[ GUANOSINE-5'-MONOPHOSPHATE ], PO4 [ PHOSPHATE ION ], MN |
| 4FF4 |
XRD |
Virus |
Escherichia virus N4(N4) |
N4 mini-vRNAP transcription initiation complex, 4 min after soaking GTP, ATP and MN |
23235152 |
2.03 Å |
IC |
N4 Virion RNAP |
5GP[ GUANOSINE-5'-MONOPHOSPHATE ], AMP[ ADENOSINE MONOPHOSPHATE ], POP[ PYROPHOSPHATE 2- ], PO4 [ PHOSPHATE ION ], MN |
| 3AGP |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral polymerase form I |
20798060 |
2.80 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
CA[ CALCIUM ION ] |
| 3AGQ |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral polymerase form II |
20798060 |
3.22 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
MG |
| 3AVT |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral RNAP complex 1 |
22245970 |
2.61 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
GH3[ 3'-deoxy-guanosine-5'-triphosphate ], CA[ CALCIUM ION ] |
| 3AVU |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral RNAP complex 2 |
22245970 |
2.91 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
CA[ CALCIUM ION ] |
| 3AVV |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral RNAP complex 3 |
22245970 |
3.12 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
CA[ CALCIUM ION ] |
| 3AVW |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral RNAP complex 4 |
22245970 |
2.60 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
GH3[ 3'-deoxy-guanosine-5'-triphosphate ], CA[ CALCIUM ION ] |
| 3AVX |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral RNAP complex 5 |
22245970 |
2.41 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
GH3[ 3'-deoxy-guanosine-5'-triphosphate ], CA[ CALCIUM ION ] |
| 3AVY |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of viral RNAP complex 6 |
22245970 |
2.62 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
CH1[ 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE ], CA[ CALCIUM ION ] |
| 3MMP |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of the qb replicase, an RNAP consisting of viral and host proteins |
20534494 |
2.50 Å |
RNAP |
Elongation Factor Tu 2/Ts,RNAP Beta Chain |
PXN[ (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol ] |
| 3VNU |
XRD |
Virus |
Escherichia virus Qbeta |
Complex structure of viral RNAP I |
22884418 |
3.20 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], CA[ CALCIUM ION ] |
| 3VNV |
XRD |
Virus |
Escherichia virus Qbeta |
Complex structure of viral RNAP II |
22884418 |
2.60 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
CH1[ 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE ], CA[ CALCIUM ION ] |
| 4FWT |
XRD |
Virus |
Escherichia virus Qbeta |
Complex structure of viral RNAP form III |
22884418 |
3.20 Å |
RNAP |
Elongation Factor Ts/Tu, Linker, Q Beta Replicase |
GTP[ Guanosine-5'-Triphosphate ], CA[ CALCIUM ION ] |
| 4Q7J |
XRD |
Virus |
Escherichia virus Qbeta |
Complex structure of viral RNAP |
25122749 |
2.90 Å |
RNAP |
Elongation Factor Ts/Tu 1,Q Beta Replicase,30s Ribosomal Protein S1 |
SO4 |
| 4R71 |
XRD |
Virus |
Escherichia virus Qbeta |
Structure of the Qbeta holoenzyme complex in the P1211 crystal form |
26578560 |
3.21 Å |
RNAP |
Elongation Factor Ts/Tu,RNAP Beta Chain,30s Ribosomal Protein S1 |
|
| 8FMB |
EM |
Virus |
Flock House virus |
Nodavirus RNA replication protein A polymerase domain, local refinement |
36693094 |
6.30 Å |
Domain |
RNA-directed RNA polymerase |
|
| 8FM9 |
EM |
Virus |
Flock House virus |
Nodavirus RNA replication proto-crown, detergent-solubliized C12 multimer |
36693094 |
3.20 Å |
RNAP |
RNA-directed RNA polymerase |
|
| 8FMA |
EM |
Virus |
Flock House virus |
Nodavirus RNA replication proto-crown, detergent-solubliized C11 multimer |
36693094 |
3.10 Å |
RNAP |
RNA-directed RNA polymerase |
|
| 1U09 |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot-and-mouth disease virus RNAP |
15294895 |
1.91 Å |
RNAP |
RNAP |
|
| 1WNE |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot-and-mouth disease virus RNAP in complex with a template-primer RNA |
15294895 |
3.00 Å |
RNAP |
RNAP |
MG |
| 2D7S |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot-and-mouth disease virus RNAP in complex with VPG protein |
16456546 |
3.00 Å |
RNAP |
RNAP,VPG1 Protein |
|
| 2E9R |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot-and-mouth disease virus RNAP in complex with a template-primer RNA and with ribavirin |
17517631 |
2.81 Å |
RNAP |
RNAP |
RTP[ RIBAVIRIN TRIPHOSPHATE ], MG |
| 2E9T |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot-and-mouth disease virus RNA-polymerase RNA dependent in complex with a template-primer RNA and 5f-UTP |
17517631 |
2.60 Å |
RNAP |
RNAP |
PPV[ PYROPHOSPHATE ], MG |
| 2E9Z |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, ATP and UTP |
17517631 |
3.00 Å |
RNAP |
RNAP |
UTP[ URIDINE 5'-TRIPHOSPHATE ], PPV[ PYROPHOSPHATE ], MG |
| 2EC0 |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
RNAP of foot-and-mouth disease virus in complex with a template-primer RNA and ATP |
17517631 |
2.75 Å |
RNAP |
RNAP |
PPV[ PYROPHOSPHATE ], MG |
| 3NKY |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Structure of a mutant P44S of foot-and-mouth disease virus RNAP |
20865120 |
2.28 Å |
RNAP |
RNAP |
MG |
| 3NL0 |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant P44S M296I of foot-and-mouth disease virus RNAP |
20865120 |
2.60 Å |
RNAP |
RNAP |
MG |
| 3NMA |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant P169S of foot-and-mouth disease virus RNA dependent RNA-polymerase |
20865120 |
2.60 Å |
RNAP |
RNAP |
MG |
| 4IQX |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant P44S P169S M296I of foot-and-mouth disease virus RNAP |
20865120 |
2.50 Å |
RNAP |
RNAP |
|
| 3KLV |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
M296I G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA |
20392853 |
2.60 Å |
RNAP |
RNAP |
MG |
| 3KMQ |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, tetragonal structure |
20392853 |
2.11 Å |
RNAP |
RNAP |
|
| 3KMS |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA trigonal structure |
20392853 |
2.20 Å |
RNAP |
RNAP |
MG |
| 3KNA |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA |
20392853 |
2.80 Å |
RNAP |
RNAP |
MG |
| 3KOA |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA and GTP |
20392853 |
2.40 Å |
RNAP |
RNAP |
DPO[ DIPHOSPHATE ], MG |
| 2F8E |
EM |
Virus |
Foot-and-mouth disease virus(FMDV) |
Foot and mouth disease virus RNAP in complex with uridylylated VPG protein |
16456546 |
2.90 Å |
RNAP |
RNAP,VPG Protein |
U5P[ URIDINE-5'-MONOPHOSPHATE ], MN, MG |
| 4WYL |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant K18E of 3D polymerase from foot-and-moth disease virus |
25903341 |
2.00 Å |
RNAP |
RNAP |
GOL, ACT[ACETATE ION], MN |
| 4WYW |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant K20E of 3D polymerase from foot-and-mouth disease virus |
25903341 |
1.80 Å |
RNAP |
RNAP |
3PO[ TRIPHOSPHATE ], GOL, ACT[ ACETATE ION ] |
| 4WZM |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant K18E of RNAP from foot-and-mouth disease virus complexed with RNA |
25903341 |
2.52 Å |
RNAP |
RNAP |
GOL, ACT[ ACETATE ION ], MN |
| 4WZQ |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant K20E of RNAP 3D from foot-and-mouth disease virus complexed with RNA |
25903341 |
2.80 Å |
RNAP |
RNAP |
MN |
| 4X2B |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
K20A RNAP mutant from foot-and-mouth disease virus complexed with an RNA |
25903341 |
2.94 Å |
RNAP |
RNAP |
MG |
| 5JXS |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant GC216/7AA of 3D polymerase from foot-and-mouth disease virus |
27194768 |
2.80 Å |
RNAP |
RNAP |
MG |
| 5N8X |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Trigonal structure of mutant V173I of 3D polymerase from foot-and-mouth disease virus |
28460010 |
2.40 Å |
RNAP |
RNAP |
GOL, MN |
| 5N95 |
EM |
Virus |
Foot-and-mouth disease virus(FMDV) |
Tetragonal structure of mutant V173I of 3D polymerase from foot-and-mouth disease virus |
28460010 |
2.60 Å |
RNAP |
RNAP |
3PO[ TRIPHOSPHATE ] |
| 6GVV |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant M16A of RNAP 3D from foot-and-mouth disease virus |
30068642 |
2.35 Å |
RNAP |
RNAP |
GOL |
| 6GVY |
EM |
Virus |
Foot-and-mouth disease virus(FMDV) |
Mutant M16A of RNAP 3D from foot-and-mouth disease virus complexed with an template -primer RNA |
30068642 |
2.20 Å |
RNAP |
RNAP |
GOL |
| 6S2L |
XRD |
Virus |
Foot-and-mouth disease virus(FMDV) |
FMDV 3D polymerase crystallized in presence of (f)uridylylated VPG peptide |
31247979 |
2.30 Å |
RNAP |
RNAP |
GOL |
| 5IZE |
XRD |
Virus |
Hantaan virus(HanV) |
Hantaan virus L protein cap-snatching endonuclease |
27304209 |
1.70 Å |
Subunit |
RNAP L |
MN3[ MANGANESE (III) ION ] |
| 2XXD |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-JFH1 NS5B polymerase structure at 1.9 angstrom |
21209117 |
1.88 Å |
RNAP |
HCV RNAP (NS5B) |
PO4 [ PHOSPHATE ION ] |
| 2XYM |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-JFH1 NS5B T385A mutant |
21209117 |
1.77 Å |
RNAP |
HCV RNAP (NS5B) |
PO4 [ PHOSPHATE ION ] |
| 3I5K |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the NS5B polymerase from hepatitis C virus (HCV) strain JFH1 |
19740982 |
2.20 Å |
RNAP |
HCV RNAP (NS5B) |
PO4 [ PHOSPHATE ION ] |
| 4AEP |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-JFH1 NS5B polymerase structure at 1.8 angstrom |
22532694 |
1.80 Å |
RNAP |
HCV RNAP (NS5B) |
PO4 [ PHOSPHATE ION ] |
| 4AEX |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-JFH1 NS5B polymerase structure at 2.4 angstrom in a primitive orthorhombic space group |
22532694 |
2.41 Å |
RNAP |
HCV RNAP (NS5B) |
PO4 [ PHOSPHATE ION ] |
| 4E+076 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Apo crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with beta hairpin loop deletion |
22496223 |
2.50 Å |
RNAP |
HCV RNAP (NS5B) |
SO4 [SULFATE ION], EDO[ 1,2-ETHANEDIOL ] |
| 4E+078 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of a product state assembly of HCV NS5B genotype 2A JFH-1 Isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG |
22496223 |
2.90 Å |
RNAP |
HCV RNAP (NS5B) |
|
| 4E7A |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of a product state assembly of HCV NS5B genotype 2A JFH-1 Isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-dDC |
22496223 |
3.00 Å |
RNAP |
HCV RNAP (NS5B) |
|
| 4OBC |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV polymerase NS5B genotype 2A JFH-1 Isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238) |
25182647 |
2.50 Å |
RNAP |
HCV RNAP (NS5B) |
PG6[ 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE , MES[ 2-(N-MORPHOLINO)-ETHANESULFONIC ACID ], GOL, CL |
| 4WT9 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Apo crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with E86Q E87Q S15G C223H V321I and DELTA8 mutations |
25678663 |
2.50 Å |
RNAP |
HCV RNAP (NS5B) |
PG6[ 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE , EPE[4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID], CL |
| 4WTA |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations and DELTA8 beta hairpin loop deletion in complex with UDP,Mn2+ and symmetrical primer template 5'-CAAAAUUU |
25678663 |
2.80 Å |
RNAP |
HCV RNAP (NS5B) |
UDP[ URIDINE-5'-DIPHOSPHATE ], MN, CL |
| 4WTC |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations and delta8 beta hairpin loop deletion in complex with CDP,Mn2+ and symmetrical primer template 5'-AGAAAUUU |
25678663 |
2.75 Å |
RNAP |
HCV RNAP (NS5B) |
CDP[ CYTIDINE-5'-DIPHOSPHATE ], MN, CL |
| 4WTD |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations and delta8 beta hairpin loop deletion in complex with ADP,Mn2+ and symmetrical primer template 5'-AUAAAUUU |
25678663 |
2.70 Å |
RNAP |
HCV RNAP (NS5B) |
ADP[ ADENOSINE-5'-DIPHOSPHATE ], MN, CL |
| 4WTE |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations and delta8 beta hairpin loop deletion in complex with GDP,Mn2+ and symmetrical primer template 5'-ACAAAUUU |
25678663 |
2.90 Å |
RNAP |
HCV RNAP (NS5B) |
GDP[ GUANOSINE-5'-DIPHOSPHATE ], MN, CL |
| 4WTF |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations and delta8 beta hairpin loop deletion in complex with GS-639475,Mn2+ and symmetrical primer template 5'-CAAAAUUU |
25678663 |
2.65 Å |
RNAP |
HCV RNAP (NS5B) |
5GS[ 2'-C-methyluridine 5'-(trihydrogen diphosphate) ], MN, CL |
| 4WTG |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations and delta8 beta hairpin loop deletion in complex with sofosbuvir diphosphate GS-607596,Mn2+ and symmetrical primer template 5'-CAAAAUUU |
25678663 |
2.90 Å |
RNAP |
HCV RNAP (NS5B) |
6GS[ 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate) ], MN, CL |
| 4WTI |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations in complex with RNA template 5'-acgg, RNA primer 5'-pcc,Mn2+, and GDP |
25678663 |
2.80 Å |
RNAP |
HCV RNAP (NS5B) |
GDP[ GUANOSINE-5'-DIPHOSPHATE ], B3P[ 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL ],MN, CL |
| 4WTJ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations in complex with RNA template 5'-aucc, RNA primer 5'-pgg,Mn2+, and ADP |
25678663 |
2.20 Å |
RNAP |
HCV RNAP (NS5B) |
ADP[ ADENOSINE-5'-DIPHOSPHATE ], PG6[ 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE ], B3P[ 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL ], MN, CL |
| 4WTL |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations in complex with RNA template 5'-uacc, RNA primer 5'-pgg,Mn2+, and UDP |
25678663 |
2.00 Å |
RNAP |
HCV RNAP (NS5B) |
UDP[ URIDINE-5'-DIPHOSPHATE ], PG6[ 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE , B3P[ 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL ], MN, CL |
| 4WTK |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations in complex with RNA template 5'-agcc, RNA primer 5'-pgg,Mn2+, and CDP |
25678663 |
2.50 Å |
RNAP |
HCV RNAP (NS5B) |
CDP[ CYTIDINE-5'-DIPHOSPHATE ] ,PG6[ 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE , B3P[ 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL ], MN, CL |
| 4WTM |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B genotype 2A JFH-1 Isolate with S15G E86Q E87Q C223H V321I mutations in complex with RNA template 5'-uagg, RNA primer 5'-pcc,Mn2+, and UDP |
25678663 |
2.15 Å |
RNAP |
HCV RNAP (NS5B) |
UDP[ URIDINE-5'-DIPHOSPHATE ], MN, CL |
| 5TWM |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus genotype 2A strain JFH1 l30s NS5B RNAP in complex with 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide |
30108798 |
1.97 Å |
RNAP |
HCV RNAP (NS5B) |
7NG[ 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide ], PE5[ 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL], PG4[TETRAETHYLENE GLYCOL ], SO4 |
| 1C2P |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP |
10504728 |
1.90 Å |
RNAP |
RNAP (NS5B) |
|
| 1CSJ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the RNAP of hepatitis C virus |
10557268 |
2.80 Å |
RNAP |
RNAP (NS5B) |
|
| 1GX5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP in complex with GTP andMn2+ |
11884572 |
1.70 Å |
RNAP |
RNAP (NS5B) |
GTP[ Guanosine-5'-Triphosphate ], MN |
| 1GX6 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP in complex with UTP andMn2+ |
11884572 |
1.85 Å |
RNAP |
RNAP (NS5B) |
UTP[ URIDINE 5'-TRIPHOSPHATE ], MN |
| 1NHU |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP in complex with non-nucleoside analogue inhibitor |
12509436 |
2.00 Å |
RNAP |
RNAP (NS5B) |
153[ (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID ] |
| 1NHV |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP in complex with non-nucleoside analogue inhibitor |
12509436 |
2.90 Å |
RNAP |
RNAP (NS5B) |
154[(2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID] |
| 1OS5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B RNAP complexed with a novel non-competitive inhibitor |
12805457 |
2.20 Å |
RNAP |
RNAP (NS5B) |
NH1[ 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE ] |
| 1QUV |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the RNA directed RNAP of hepatitis C virus |
10574802 |
2.50 Å |
RNAP |
RNAP (NS5B) |
|
| 2AWZ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP in complex with a covalent inhibitor (5H) |
16451069 |
2.15 Å |
RNAP |
RNAP (NS5B) |
5H[ 5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE ] , SO4 |
| 2AX0 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP in complex with a covalent inhibitor (5X) |
16451069 |
2.00 Å |
RNAP |
RNAP (NS5B) |
5X[ 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE ] , SO4 |
| 2AX1 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP in complex with a covalent inhibitor (5EE) |
16451069 |
2.10 Å |
RNAP |
RNAP (NS5B) |
5EE[ 5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE ] , SO4 |
| 2BRK |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1) |
15955819 |
2.30 Å |
RNAP |
RNAP (NS5B) |
CMF[ 3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID ] , MN |
| 2BRL |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 2) |
15955819 |
2.40 Å |
RNAP |
RNAP (NS5B) |
POO[ 3-CYCLOHEXYL-1-(2-{METHYL[(1-METHYLPIPERIDIN-3-YL)METHYL]AMINO}-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID ], MN |
| 2DXS |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B RNAP complexed with a tetracyclic inhibitor |
17125247 |
2.20 Å |
RNAP |
RNAP (NS5B) |
JTP[ N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE ] |
| 2GIQ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP NS5B with NNI-2 inhibitor |
16731953 |
1.65 Å |
RNAP |
RNAP (NS5B) |
NN2[ 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE ] |
| 2GIR |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP NS5B with NNI-1 inhibitor |
16731953 |
1.90 Å |
RNAP |
RNAP (NS5B) |
NN3[ 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID ] |
| 2HAI |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B RNAP in complex with novel Classification of dihydropyrone-containing inhibitor. |
16824756 |
1.58 Å |
RNAP |
RNAP (NS5B) |
PFI[ (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE ] |
| 2HWH |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B allosteric inhibitor complex |
16934455 |
2.30 Å |
RNAP |
RNAP (NS5B) |
RNA[ 4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE ] |
| 2HWI |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B allosteric inhibitor complex |
16934455 |
2.00 Å |
RNAP |
RNAP (NS5B) |
VRX[ (2S)-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)(4-FLUOROPHENYL)ACETIC ACID ] |
| 2I1R |
XRD |
Virus |
Hepatitis C virus(HCV) |
Novel thiazolones as HCV NS5B polymerase inhibitors: further designs, synthesis, sar and X-ray complex structure |
17049849 |
2.20 Å |
RNAP |
RNAP (NS5B) |
VXR[ (5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE ] |
| 2JC0 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus polymerase in complex with inhibitor SB655264 |
17269759 |
2.20 Å |
RNAP |
RNAP (NS5B) |
699[ (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID ] |
| 2JC1 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus polymerase in complex with inhibitor SB698223 |
17269759 |
2.00 Å |
RNAP |
RNAP (NS5B) |
698[ (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID ] |
| 2O5D |
XRD |
Virus |
Hepatitis C virus(HCV) |
Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study |
17276060 |
2.20 Å |
RNAP |
RNAP (NS5B) |
VR1[ (2S)-2-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)-2-(4-FLUOROPHENYL)-N-[(4-NITROPHENYL)SULFONYL]ACETAMIDE ] |
| 2WCX |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus NS5B polymerase in complex with thienopyrrole-based finger-loop inhibitors |
19672916 |
2.00 Å |
RNAP |
RNAP (NS5B) |
VGC[ 6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC ACID ] |
| 2WHO |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus NS5B polymerase from 1b genotype in complex with a non-nucleoside inhibitor |
19877603 |
2.00 Å |
RNAP |
RNAP (NS5B) |
VGI[ 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione ] , MN |
| 2WRM |
XRD |
Virus |
Hepatitis C virus(HCV) |
Identification of novel allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain (site II) by structure-based design |
To be published. |
1.95 Å |
RNAP |
RNAP (NS5B) |
QQ3[ (3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC ACID ] |
| 2XWY |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of MK-3281, a potent non-nucleoside finger-loop inhibitor, in complex with the hepatitis C virus NS5B polymerase |
21141896 |
2.53 Å |
RNAP |
RNAP (NS5B) |
IB8[ (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid ] , MN |
| 2ZKU |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of hepatitis C virus NS5B polymerase in a new crystal form |
To be published. |
1.95 Å |
RNAP |
RNAP (NS5B) |
GOL, ACY[ACETIC ACID] |
| 3BR9 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18242088 |
2.30 Å |
RNAP |
RNAP (NS5B) |
DEY[ (2R)-2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)propanamide ] |
| 3BSA |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18242088 |
2.30 Å |
RNAP |
RNAP (NS5B) |
1PD[ 2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(1,3-thiazol-5-yl)-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)acetamide ] |
| 3BSC |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18242088 |
2.65 Å |
RNAP |
RNAP (NS5B) |
2PD[ 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one ] |
| 3CDE |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18457949 |
2.10 Å |
RNAP |
RNAP (NS5B) |
N3H[ N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide ] |
| 3CIZ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus RNAP NS5B in complex with small molecule fragments |
18400495 |
1.87 Å |
RNAP |
RNAP (NS5B) |
SX1[ 2-amino-5-bromobenzoic acid ] , ZN |
| 3CJ0 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus RNAP NS5B in complex with small molecule fragments |
18400495 |
1.90 Å |
RNAP |
RNAP (NS5B) |
SX2[ 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid ] |
| 3CJ2 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus RNAP NS5B in complex with optimized small molecule fragments |
18400495 |
1.75 Å |
RNAP |
RNAP (NS5B) |
SX3[ 4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}aniline ] , NI |
| 3CJ3 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus RNAP NS5B in complex with optimized small molecule fragments |
18400495 |
1.87 Å |
RNAP |
RNAP (NS5B) |
SX4[ 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline ] , NI |
| 3CJ4 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus RNAP NS5B in complex with optimized small molecule fragments |
18400495 |
2.07 Å |
RNAP |
RNAP (NS5B) |
SX5[ 4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid ] , NI |
| 3CJ5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of hepatitis C virus RNAP NS5B in complex with optimized small molecule fragments |
18400495 |
1.92 Å |
RNAP |
RNAP (NS5B) |
SX6[ N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide ] |
| 3CO9 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18487044 |
2.10 Å |
RNAP |
RNAP (NS5B) |
3MS[ N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7 -yl}methanesulfonamide ] |
| 3CVK |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18722768 |
2.31 Å |
RNAP |
RNAP (NS5B) |
N34[ N-{3-[1-(3,3-Dimethyl-butyl)-4-hydroxy-2-oxo-1,2,4a,5,6,7-hexahydro-pyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,2-dihydro -1lambda6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide ] |
| 3CWJ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18662878 |
2.40 Å |
RNAP |
RNAP (NS5B) |
321[ N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide ] |
| 3D28 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel benzisothiazole inhibitor |
18554907 |
2.30 Å |
RNAP |
RNAP (NS5B) |
B34[ (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one ] |
| 3D5M |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18554907 |
2.20 Å |
RNAP |
RNAP (NS5B) |
4MS[ N-({3-[(5S)-5-tert-butyl-1-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzis othiazol-7-yl}methyl)methanesulfonamide ] |
| 3E+051 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor |
18796353 |
1.90 Å |
RNAP |
RNAP (NS5B) |
N35[ N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-pyrrolidin-1-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide ] |
| 3FQK |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (BK 1-570) with HCV-796 inhibitor |
19246450 |
2.20 Å |
RNAP |
RNAP (NS5B) |
79Z[ 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide ] |
| 3FRZ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B RNAP in complex with PF868554 |
19209845 |
1.86 Å |
RNAP |
RNAP (NS5B) |
AG6[ N-[(benzyloxy)carbonyl]-L-alpha-glutamyl-N-[(1S)-4-oxo-4-phenyl-1-propylbut-2-en-1-yl]-L-phenylalaninamide ], AG0[ (6R)-6-cyclopentyl-6-[2-(2,6-diethylpyridin-4-yl)ethyl]-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-5,6-d |
| 3G86 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor |
19457662 |
2.20 Å |
RNAP |
RNAP (NS5B) |
T18[ N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide), N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}me |
| 3GYN |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor |
19796938 |
2.15 Å |
RNAP |
RNAP (NS5B) |
B42[ N-{3-[(5R)-1-cyclopentyl-4-hydroxy-5-methyl-5-(3-methylbutyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide ] |
| 3H2L |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor |
19818610 |
1.90 Å |
RNAP |
RNAP (NS5B) |
YAK[ N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide ] |
| 3IGV |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydro-pyridinone inhibitor |
19796938 |
2.60 Å |
RNAP |
RNAP (NS5B) |
B80[ N-{3-[(6S)-6-ethyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide ] |
| 3MF5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor |
20584604 |
2.00 Å |
RNAP |
RNAP (NS5B) |
HJZ[ 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid ] , GOL |
| 3H59 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 |
19700319 |
2.10 Å |
RNAP |
RNAP (NS5B) |
H59[ N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide ] |
| 3H5S |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B with saccharin inhibitor |
19709881 |
2.00 Å |
RNAP |
RNAP (NS5B) |
H5S[ (5S)-5-tert-butyl-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-3-[8-(methylsulfonyl)-1,1-dioxido-6,7,8,9-tetrahydroisothiazolo[4,5-h]isoquinolin-3-yl]-1,5-dihydro-2H-pyrrol-2-one ] |
| 3H5U |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B with saccharin inhibitor 1 |
19709881 |
1.95 Å |
RNAP |
RNAP (NS5B) |
H5U[ N-({3-[(5S)-5-tert-butyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzisothiazol-7-yl}methyl)methanesulfonamide ] |
| 3H98 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B 1b with (1,1-dioxo-2h-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative |
19500983 |
1.90 Å |
RNAP |
RNAP (NS5B) |
B5P[ N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide ] , GOL |
| 3UDL |
XRD |
Virus |
Hepatitis C virus(HCV) |
3-heterocyclyl quinolone bound to HCV NS5B |
21145235 |
2.17 Å |
RNAP |
RNAP (NS5B) |
KLI[ 3-(5-benzyl-1,2,4-oxadiazol-3-yl)-6-fluoro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one ] |
| 3VQS |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B RNAP with a novel piperazine inhibitor |
22615294 |
1.90 Å |
RNAP |
RNAP (NS5B) |
JT1[ (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide ] , CL |
| 4EO6 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres |
22664130 |
1.79 Å |
RNAP |
RNAP (NS5B) |
0S2[ 5-(3,3-dimethylbut-1-yn-1-yl)-3-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}thiophene-2-carboxylic acid ] |
| 4EO8 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres |
22664130 |
1.80 Å |
RNAP |
RNAP (NS5B) |
0S3[ 5-(3,3-dimethylbut-1-yn-1-yl)-3-{2,2-dimethyl-1-[(trans-4-methylcyclohexyl)carbonyl]hydrazinyl}thiophene-2-carboxylic acid ] |
| 4IH5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (BK) with fragment-based compounds |
23509929 |
1.90 Å |
RNAP |
RNAP (NS5B) |
12R[ 4-(2-phenylhydrazinyl)-1H-pyrazolo[3,4-d]pyrimidine ] |
| 4IH6 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (BK) with fragment-based compounds |
23509929 |
2.20 Å |
RNAP |
RNAP (NS5B) |
1EP[ (5S)-3-(4-tert-butylbenzyl)-5-(propan-2-yl)imidazolidine-2,4-dione ] |
| 4IH7 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (BK) with fragment-based compounds |
23509929 |
2.30 Å |
RNAP |
RNAP (NS5B) |
1ER[ 3-(3-tert-butylphenyl)pyridin-2(1H)-one ] , ZN |
| 4KAI |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B GT1B N316 with GSK5852A |
23672667 |
2.30 Å |
RNAP |
RNAP (NS5B) |
1PV[ [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid ] |
| 4KB7 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B GT1B N316Y with CMPD 32 |
23672667 |
1.85 Å |
RNAP |
RNAP (NS5B) |
690[ 5-cyclopropyl-2-(4-fluorophenyl)-6-[{2-[(3R)-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl]ethyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide ] |
| 4KBI |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B GT1B N316Y with CMPD 4 |
23672667 |
2.06 Å |
RNAP |
RNAP (NS5B) |
1C0[ 5-cyclopropyl-6-{[(7-fluoro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide ] |
| 4KE5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B GT1B N316Y with GSK5852 |
23672667 |
2.11 Å |
RNAP |
RNAP (NS5B) |
1PV[ [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid ] |
| 4MIA |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with RG7109 |
24195700 |
2.80 Å |
RNAP |
RNAP (NS5B) |
28L[ N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide ] , ZN |
| 4MIB |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with compound 48 |
24195700 |
2.30 Å |
RNAP |
RNAP (NS5B) |
28M[ N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide ] , DMS[ DIMETHYL SULFOXIDE ] |
| 4MK7 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 2 (3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1h)-one) |
24069953 |
2.80 Å |
RNAP |
RNAP (NS5B) |
28O[ 3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1H)-one] , DMS[DIMETHYL SULFOXIDE ], MG |
| 4MK8 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 4 |
24069953 |
2.09 Å |
RNAP |
RNAP (NS5B) |
28Q[ N-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide ] , GOL, DMS[ DIMETHYL SULFOXIDE ] |
| 4MK9 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 12 |
24069953 |
2.05 Å |
RNAP |
RNAP (NS5B) |
28R[ N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide ] , GOL |
| 4MKA |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 13 |
24069953 |
2.05 Å |
RNAP |
RNAP (NS5B) |
2AY[ N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1-oxo-1H-isochromen-7-yl}methanesulfonamide ] , GOL, DMS[ DIMETHYL SULFOXIDE ] |
| 4MKB |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 14 |
24069953 |
1.90 Å |
RNAP |
RNAP (NS5B) |
28V[ N-(4-{(E)-2-[3-tert-butyl-2-methoxy-5-(3-oxo-2,3-dihydropyridazin-4-yl)phenyl]ethenyl}phenyl)methanesulfonamide ] |
| 4TN2 |
XRD |
Virus |
Hepatitis C virus(HCV) |
NS5B in complex with lactam-thiophene carboxylic acids |
24986660 |
2.70 Å |
RNAP |
RNAP (NS5B) |
33J[ 3-[(2R)-2-cyclohexyl-5-oxopyrrolidin-1-yl]-5-phenylthiophene-2-carboxylic acid ] |
| 5W2E |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B RNAP in complex with non-nucleoside inhibitor MK-8876 |
28741898 |
2.80 Å |
RNAP |
RNAP (NS5B) |
9VY[ 2-(4-fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide ] |
| 6MVP |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B 1b N316 bound to compound 18 |
30763090 |
2.00 Å |
RNAP |
RNAP (NS5B) |
K4S[ (4-{[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}phenyl)boronic acid ] |
| 1NB4 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HC-J4 RNAP apo-form |
12589751 |
2.00 Å |
RNAP |
RNAP (NS5B) |
|
| 1NB6 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HC-J4 RNAP complexed with UTP |
12589751 |
2.60 Å |
RNAP |
RNAP (NS5B) |
UTP[ URIDINE 5'-TRIPHOSPHATE ], MN |
| 1NB7 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HC-J4 RNAP complexed with short RNA template strand |
12589751 |
2.90 Å |
RNAP |
RNAP (NS5B) |
MN |
| 2XHU |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-I4 NS5B polymerase orthorhombic crystal form |
20729191 |
2.29 Å |
RNAP |
RNAP (NS5B) |
SO4 |
| 2XHV |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-I4 NS5B polymerase point mutant orthorhombic crystal form |
20729191 |
1.90 Å |
RNAP |
RNAP (NS5B) |
SO4, MG |
| 2XHW |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-I4 NS5B polymerase trigonal crystal form |
20729191 |
2.66 Å |
RNAP |
RNAP (NS5B) |
|
| 2YOJ |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase complexed with pyridonylindole compound |
24900812 |
1.76 Å |
RNAP |
RNAP (NS5B) |
8Y6[ 4-fluoranyl-6-[(7-fluoranyl-4-oxidanylidene-3H-quinazolin-6-yl)methyl]-8-(2-oxidanylidene-1H-pyridin-3-yl)furo[2,3-e]indole-7-carboxylic acid] , PO4[PHOSPHATE ION ] |
| 3CSO |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV polymerase in complex with a 1,5 benzodiazepine inhibitor |
18852280 |
2.71 Å |
RNAP |
RNAP (NS5B) |
XNI[ (11S)-10-acetyl-11-[4-(benzyloxy)-3-chlorophenyl]-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one ] |
| 3GNV |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b |
19507864 |
2.75 Å |
RNAP |
RNAP (NS5B) |
XNZ[ (11R)-10-acetyl-11-[4-(benzyloxy)-2-chlorophenyl]-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one ] , GOL |
| 3GNW |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c |
19507864 |
2.39 Å |
RNAP |
RNAP (NS5B) |
XNC[ (11S)-11-[4-(benzyloxy)-2-fluorophenyl]-3,3-dimethyl-10-[(6-methylpyridin-2-yl)carbonyl]-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide ] , CL |
| 3GOL |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor (r)-11d |
19342234 |
2.85 Å |
RNAP |
RNAP (NS5B) |
XND[ (11R)-10-acetyl-11-(2,4-dichlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one ] , MG |
| 3HKY |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase genotype 1b in complex with 1,5 benzodiazepine 6 |
20071590 |
1.90 Å |
RNAP |
RNAP (NS5B) |
IX6[ (11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide ] , SO4, CL |
| 3LKH |
XRD |
Virus |
Hepatitis C virus(HCV) |
Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 6-fluoro-N-[2-hydroxy-1(s)-benzamides |
20219368 |
2.05 Å |
RNAP |
RNAP (NS5B) |
LT6[ 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide ] |
| 3MWV |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase |
20942454 |
2.20 Å |
RNAP |
RNAP (NS5B) |
|
| 3MWW |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase |
20942454 |
2.80 Å |
RNAP |
RNAP (NS5B) |
BIW[ 1-[2-(4-carboxypiperidin-1-yl)-2-oxoethyl]-3-cyclohexyl-2-furan-3-yl-1H-indole-6-carboxylic acid ] , SO4 |
| 3SKA |
XRD |
Virus |
Hepatitis C virus(HCV) |
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2- carboxylic acids with c3-heterocycles |
21840715 |
1.73 Å |
RNAP |
RNAP (NS5B) |
053[ 1-[(2-aminopyridin-4-yl)methyl]-3-(2-oxo-1,2-dihydropyridin-3-yl)-5-(trifluoromethyl)-1H-indole-2-carboxylic acid ] , PO4 |
| 3SKE |
XRD |
Virus |
Hepatitis C virus(HCV) |
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2- carboxylic acids with c3-heterocycles |
21840715 |
1.97 Å |
RNAP |
RNAP (NS5B) |
054[ 1-[(2-aminopyridin-4-yl)methyl]-3-(2,4-dioxo-1,2-dihydrothieno[3,4-d]pyrimidin-3(4H)-yl)-5-(trifluoromethyl)-1H-indole-2-carboxylic acid ] , PO4 |
| 3SKH |
XRD |
Virus |
Hepatitis C virus(HCV) |
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2- carboxylic acids with c3-heterocycles |
21840715 |
2.50 Å |
RNAP |
RNAP (NS5B) |
058[ 1-benzyl-5-chloro-3-(2-fluorophenyl)-1H-indole-2-carboxylic acid ] |
| 3TYQ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Sar development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase |
22247956 |
1.60 Å |
RNAP |
RNAP (NS5B) |
HI4[ 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid ] , PO4 |
| 3TYV |
XRD |
Virus |
Hepatitis C virus(HCV) |
Sar development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase |
22148957 |
1.65 Å |
RNAP |
RNAP (NS5B) |
HI3[ N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide ] , PO4 |
| 3U4O |
XRD |
Virus |
Hepatitis C virus(HCV) |
Novel HCV NS5B polymerase inhibitors: discovery of indole c2 acyl sulfonamides |
22104146 |
1.77 Å |
RNAP |
RNAP (NS5B) |
08E[ 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid ] , PO4 |
| 3U4R |
XRD |
Virus |
Hepatitis C virus(HCV) |
Novel HCV NS5B polymerase inhibitors: discovery of indole c2 acyl sulfonamides |
22104146 |
2.00 Å |
RNAP |
RNAP (NS5B) |
08F[ 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-N-({3-[(methylsulfonyl)amino]phenyl}sulfonyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide ] |
| 3UPH |
XRD |
Virus |
Hepatitis C virus(HCV) |
Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors |
22220815 |
2.00 Å |
RNAP |
RNAP (NS5B) |
0C1[ 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide ] , PO4 |
| 3UPI |
XRD |
Virus |
Hepatitis C virus(HCV) |
Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors |
22220815 |
2.00 Å |
RNAP |
RNAP (NS5B) |
0C2[ (3S)-6-(2,5-difluorobenzyl)-3-methyl-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide ] , PO4 |
| 4DRU |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B in complex with macrocyclic indole inhibitor |
22473861 |
2.10 Å |
RNAP |
RNAP (NS5B) |
0LN[ 13-cyclohexyl-3-methoxy-17,22-dimethyl-7H-10,6-(methanoiminothioiminobutanoiminomethano)indolo[2,1-a][2]benzazepine-14,23-dione 16,16-dioxide ] , SO4, GOL |
| 4EAW |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B in complex with Idx375 |
To be published. |
2.00 Å |
RNAP |
RNAP (NS5B) |
0NQ[ N-{(1S)-3-[(5S)-5-tert-butyl-1-(3,3-dimethylbutyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1-ethoxy-1-oxido-1,4-dihydro-2,4,1-benzodiazaphosphinin-7-yl}methanesulfonamide ] , PEG[ DI(HYDROXYETHYL)ETHER ], SO4, EDO[1,2-ETHANEDIOL] |
| 4GMC |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with a thumb inhibitor |
|
2.70 Å |
RNAP |
RNAP (NS5B) |
1BI[ 3-cyclohexyl-2-(furan-3-yl)-1-[2-(morpholin-4-yl)-2-oxoethyl]-N-(phenylsulfonyl)-1H-indole-6-carboxamide ] , SO4 |
| 4IZ0 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide |
23545108 |
2.22 Å |
RNAP |
RNAP (NS5B) |
2BI[ 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide ] |
| 4J02 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with [(1r)-5,8-dichloro-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid |
23545108 |
2.00 Å |
RNAP |
RNAP (NS5B) |
1JE[ [(1R)-5,8-dichloro-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid ] , SO4 , NA |
| 4J04 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with 4-chloro-2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid |
23545108 |
2.00 Å |
RNAP |
RNAP (NS5B) |
1JF[ 4-chloro-2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid ] , MN |
| 4J06 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with 2-{[(5-bromothiophen-2-yl)sulfonyl]amino}-4-chlorobenzoic acid |
23545108 |
2.00 Å |
RNAP |
RNAP (NS5B) |
1JG[ 2-{[(5-bromothiophen-2-yl)sulfonyl]amino}-4-chlorobenzoic acid ] |
| 4J08 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with 2-{[(4-methylphenyl)sulfonyl]amino}-5-phenoxybenzoic acid |
23545108 |
2.10 Å |
RNAP |
RNAP (NS5B) |
1JH[ 2-{[(4-methylphenyl)sulfonyl]amino}-5-phenoxybenzoic acid ] |
| 4J0A |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with 2-{[(4-methylphenyl)sulfonyl]amino}-4-phenoxybenzoic acid |
23545108 |
2.40 Å |
RNAP |
RNAP (NS5B) |
1JL[ 2-{[(4-methylphenyl)sulfonyl]amino}-4-phenoxybenzoic acid ] |
| 4JJS |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 2 |
23768906 |
2.20 Å |
RNAP |
RNAP (NS5B) |
1M9[ 2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}-5-[2-(trifluoromethyl)phenoxy]benzoic acid ] , MG |
| 4JJU |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 29 |
23768906 |
1.91 Å |
RNAP |
RNAP (NS5B) |
1MB[ 1-(2,4-difluorobenzyl)-6-{[3-(trifluoromethyl)pyridin-2-yl]oxy}quinazolin-4(1H)-one ] , GOL, MG |
| 4JTW |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with coupound 1 |
23773186 |
3.00 Å |
RNAP |
RNAP (NS5B) |
1NU[ 1-(2,4,6-trifluorobenzyl)-6-[2-(trifluoromethyl)phenoxy]quinazolin-4(1H)-one ] , GOL, MG |
| 4JTY |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase with compound 2 |
23773186 |
2.60 Å |
RNAP |
RNAP (NS5B) |
1NV[ 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-2-(trifluoromethyl)benzamide ] , GOL, MG |
| 4JTZ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 4 |
23773186 |
2.80 Å |
RNAP |
RNAP (NS5B) |
1NW[ 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-N-(pyridin-3-yl)-2-(trifluoromethyl)benzamide ] , GOL, MG |
| 4JU1 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 6 |
23773186 |
2.90 Å |
RNAP |
RNAP (NS5B) |
1NZ[ 6-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)-2-(trifluoromethyl)phenoxy]-1-(2,4,6-trifluorobenzyl)quinazolin-4(1H)-one ] , GOL, MG |
| 4JU2 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 12 |
23773186 |
2.70 Å |
RNAP |
RNAP (NS5B) |
1O0 [6-[3-(pyridin-2-yl)-2-(trifluoromethyl)phenoxy]-1-(2,4,6-trifluorobenzyl)quinazolin-4(1H)-one ] , GOL, MG |
| 4JU3 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 8 |
24176401 |
2.00 Å |
RNAP |
RNAP (NS5B) |
1O1[ 5-(4-carboxyphenoxy)-2-{[(4-methylphenyl)sulfonyl]amino}benzoic acid ] , MG |
| 4JU4 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 22 |
24176401 |
2.40 Å |
RNAP |
RNAP (NS5B) |
1O3[ 2-{[(4-bromo-2-fluorophenyl)sulfonyl]amino}-5-phenoxybenzoic acid ] , MG |
| 4JU6 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 24 |
24176401 |
2.20 Å |
RNAP |
RNAP (NS5B) |
1O6[ 2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}-5-phenoxybenzoic acid ] , MG |
| 4JU7 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 24 |
24176401 |
2.20 Å |
RNAP |
RNAP (NS5B) |
1O6[ 2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}-5-phenoxybenzoic acid ] , MG |
| 4JVQ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 9 |
24024973 |
2.40 Å |
RNAP |
RNAP (NS5B) |
1ML[ 5-{4-[(4-methoxybenzoyl)amino]phenoxy}-2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}benzoic acid ] , GOL, MG |
| 4JY0 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 3 |
To be published. |
2.20 Å |
RNAP |
RNAP (NS5B) |
1O9[C [auth A], D [auth B] (4S,5R)-1-(4-tert-butylbenzoyl)-2-(2-methylpropyl)-4-pyrazin-2-yl-5-(1,3-thiazol-2-yl)-L-proline ] |
| 4JY1 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of HCV NS5B polymerase in complex with compound 5 |
To be published. |
2.60 Å |
RNAP |
RNAP (NS5B) |
NN3[ 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID ] |
| 4MZ4 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Discovery of an Irreversible HCV NS5B polymerase inhibitor |
24252545 |
1.63 Å |
RNAP |
RNAP (NS5B) |
2F3[ 1-[(2-chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid ] , PO4 |
| 4OOW |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase with a fragment of quercetagetin |
25053847 |
2.57 Å |
RNAP |
RNAP (NS5B) |
CAQ(CATECHOL) |
| 4RY4 |
XRD |
Virus |
Hepatitis C virus(HCV) |
C-terminal mutant (Y448F) of HCV/j4 RNAP |
25428878 |
2.59 Å |
RNAP |
HCV J4 RNAP (NS5B) |
|
| 4RY5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
C-terminal mutant (W550N) of HCV/J4 RNAP |
25428878 |
2.71 Å |
RNAP |
HCV J4 RNAP (NS5B) |
UTP[ URIDINE 5'-TRIPHOSPHATE ], MN |
| 4RY6 |
XRD |
Virus |
Hepatitis C virus(HCV) |
C-terminal mutant (W550A) of HCV/J4 RNAP |
25428878 |
2.52 Å |
RNAP |
HCV J4 RNAP (NS5B) |
|
| 4RY7 |
XRD |
Virus |
Hepatitis C virus(HCV) |
C-terminal mutant (D559E) of HCV/J4 RNAP |
25428878 |
3.00 Å |
RNAP |
HCV J4 RNAP (NS5B) |
|
| 5CZB |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B in complex with ligand Idx17119-5 |
27520942 |
1.96 Å |
RNAP |
RNAP (NS5B) |
55W[ 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid ] , MES[ 2-(N-MORPHOLINO)-ETHANESULFONIC ACID ], PEG[ DI(HYDROXYETHYL)ETHER ], SO4, GOL |
| 2XI3 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-h77 NS5B polymerase complexed with GTP |
20729191 |
1.70 Å |
RNAP |
RNAP (NS5B) |
GTP[ Guanosine-5'-Triphosphate ], MG |
| 2D3U |
XRD |
Virus |
Hepatitis C virus(HCV) |
X-ray crystal structure of hepatitis C virus RNAP in complex with non-nucleoside analogue inhibitor |
16828488 |
2.00 Å |
RNAP |
RNAP (NS5B) |
CCT[ 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID ] |
| 2D3Z |
XRD |
Virus |
Hepatitis C virus(HCV) |
X-ray crystal structure of hepatitis C virus RNAP in complex with non-nucleoside analogue inhibitor |
16828488 |
1.80 Å |
RNAP |
RNAP (NS5B) |
FIH[ 5-(4-FLUOROPHENYL)-3-{[(4-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID ] |
| 2D41 |
XRD |
Virus |
Hepatitis C virus(HCV) |
X-ray crystal structure of hepatitis C virus RNAP in complex with non-nucleoside inhibitor |
16828488 |
2.10 Å |
RNAP |
RNAP (NS5B) |
SNH[ 5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID ] |
| 2FVC |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-dioxo-2h-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1h)-quinolinone |
16451063 |
2.00 Å |
RNAP |
RNAP (NS5B) |
888[ 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one ] |
| 2GC8 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of a proline sulfonamide inhibitor bound to HCV NS5B polymerase |
16722622 |
2.20 Å |
RNAP |
RNAP (NS5B) |
885[ 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE ] |
| 2IJN |
XRD |
Virus |
Hepatitis C virus(HCV) |
Isothiazoles as activE-site inhibitors of HCV NS5B polymerase |
17049853 |
2.20 Å |
RNAP |
RNAP (NS5B) |
221[ (2R,3R)-3-{[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO}-2-CYANO-3-THIOXOPROPANAMIDE ] |
| 2QE2 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of HCV NS5B bound to an anthranilic acid inhibitor |
17402724 |
2.90 Å |
RNAP |
RNAP (NS5B) |
452[ 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID ] |
| 2QE5 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of HCV NS5B bound to an anthranilic acid inhibitor |
17402724 |
2.60 Å |
RNAP |
RNAP (NS5B) |
617[ 2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID ] |
| 3HHK |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B polymerase complex with a substituted benzothiadizine |
19515564 |
1.70 Å |
RNAP |
RNAP (NS5B) |
77Z[ 2-({(3R)-3-[(3S)-1-(3-methylbutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl]-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide ] |
| 6MVK |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B 1b n316 bound to compound 18 |
30763090 |
2.30 Å |
RNAP |
RNAP (NS5B) |
K4J[ (4-{(4S)-3-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-2-oxo-1,3-oxazolidin-4-yl}-2-fluorophenyl)boronic acid ] |
| 6MVQ |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B 1b n316 bound to compound 31 |
30763090 |
2.14 Å |
RNAP |
RNAP (NS5B) |
K4M[(4-{1-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-1H-1,2,4-triazol-5-yl}-2-fluorophenyl)boronic acid] |
| 3HKW |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B genotype 1a in complex with 1,5 benzodiazepine inhibitor 6 |
20071590 |
1.55 Å |
RNAP |
RNAP (NS5B) |
IX6[(11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide] , SO4, GOL |
| 3QGH |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP genotype 1a complex with N-cyclopropyl-6-[(3r)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide |
21441029 |
2.14 Å |
RNAP |
RNAP (NS5B) |
63F[N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide] , PO4 |
| 3QGI |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP genotype 1a complex with N-[(2s)-butan-2-yl]-6-[(3r)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide |
21441029 |
1.80 Å |
RNAP |
RNAP (NS5B) |
33F[N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide] , GOL |
| 6MVO |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B 1a y316 bound to compound 49 |
30763090 |
1.95 Å |
RNAP |
RNAP (NS5B) |
K4P[6-[(7-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide] , SO4 |
| 4KHM |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B GT1A with gsk5852 |
23672667 |
1.70 Å |
RNAP |
RNAP (NS5B) |
1PV[[4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid] , SO4 |
| 4KHR |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B GT1A c316y with gsk5852 |
23672667 |
2.45 Å |
RNAP |
RNAP (NS5B) |
1PV[[4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid] , SO4 |
| 3PHE |
EM |
Virus |
Hepatitis C virus(HCV) |
HCV NS5B with a bound quinolone inhibitor |
21145235 |
2.20 Å |
RNAP |
RNAP (NS5B) |
C9A[4-chlorobenzyl 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(methylsulfonyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate] |
| 4TXS |
EM |
Virus |
Hepatitis C virus(HCV) |
An ligand-observed mass spectrometry-based approach integrated into the fragment based lead discovery pipeline |
25666181 |
2.78 Å |
RNAP |
RNAP (NS5B) |
3AQ[(4-hydroxyphenyl)acetonitrile] |
| 4TY8 |
XRD |
Virus |
Hepatitis C virus(HCV) |
An ligand-observed mass spectrometry-based approach integrated into the fragment based lead discovery pipeline |
25666181 |
2.78 Å |
RNAP |
RNAP (NS5B) |
3AV[6-methyl-2H-chromen-2-one] |
| 4TY9 |
XRD |
Virus |
Hepatitis C virus(HCV) |
An ligand-observed mass spectrometry-based approach integrated into the fragment based lead discovery pipeline |
25666181 |
2.78 Å |
RNAP |
RNAP (NS5B) |
3B0[5-(trifluoromethyl)pyridin-2-amine] |
| 4TYA |
XRD |
Virus |
Hepatitis C virus(HCV) |
An ligand-observed mass spectrometry-based approach integrated into the fragment based lead discovery pipeline |
25666181 |
2.94 Å |
RNAP |
RNAP (NS5B) |
3AE[4-(trifluoromethyl)benzoic acid] |
| 1YUY |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP genotype 2A |
15746101 |
1.90 Å |
RNAP |
RNAP (NS5B) |
SO4 |
| 1YV2 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP genotype 2A |
15746101 |
2.50 Å |
RNAP |
RNAP (NS5B) |
SO4, GOL |
| 1YVX |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP genotype 2A in complex with non- nucleoside analogue inhibitor |
15746101 |
2.00 Å |
RNAP |
RNAP (NS5B) |
IPC[3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID] , SO4 |
| 1YVZ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus RNAP genotype 2A in complex with non- nucleoside analogue inhibitor |
15746101 |
2.20 Å |
RNAP |
RNAP (NS5B) |
JPC[3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID] , SO4 |
| 2XWH |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-j6 NS5B polymerase structure at 1.8 angstrom |
21209117 |
1.80 Å |
RNAP |
RNAP (NS5B) |
15P[POLYETHYLENE GLYCOL (N=34)], PEG[ DI(HYDROXYETHYL)ETHER ] |
| 4ADP |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-j6 NS5B polymerase V405I mutant |
22532694 |
1.90 Å |
RNAP |
RNAP (NS5B) |
|
| 3Q0Z |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid |
21486696 |
2.29 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , SO4 |
| 3QGD |
EM |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2r)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-N-(4-methoxybenzyl)piperazine-2-carboxamide |
21441029 |
2.60 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 26S[(2R)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-N-(4-methoxybenzyl)p |
| 3QGE |
EM |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2r)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide |
21441029 |
3.00 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 26F[(2R)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phen |
| 3QGF |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2r)-4-(6-chloropyridazin-3-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide |
21441029 |
2.45 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 46F[(2R)-4-(6-chloropyridazin-3-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]su |
| 3QGG |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and N-cyclopropyl-6-[(3r)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide |
21441029 |
3.22 Å |
RNAP |
RNAP (NS5B) |
63F[N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide] , 23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl |
| 4NLD |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP complex with bms-791325 also known as (1ar,12bs)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide |
24397558 |
2.75 Å |
RNAP |
RNAP (NS5B) |
2N7[(1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide] , 2N5[2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl |
| 5PZK |
EM |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide |
28430437 |
2.20 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 2N5[2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran |
| 5PZL |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 2-({3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda~6~,2,4-benzothiadiazin-7-yl}oxy)acetamide |
28430437 |
2.06 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 8XV[2-({3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1- |
| 5PZM |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 3-[2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-5-yl]benzoic acid |
28430437 |
2.54 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 8XS[3-[2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-5-yl]benzoic acid] , GOL,SO4 |
| 5PZN |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 5-[3-(tert-butylcarbamoyl)phenyl]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide |
28430437 |
2.25 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 8XP[5-[3-(tert-butylcarbamoyl)phenyl]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxam |
| 5PZO |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP c316n in complex with 2-(4-fluorophenyl)-N-methyl-5-[3-({2-methyl-1-oxo-1-[(1,3,4-thiadiazol-2-yl)amino]propan-2-yl}carbamoyl)phenyl]-1-benzofuran-3-carboxamide |
28430437 |
2.80 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 8XM[2-(4-fluorophenyl)-N-methyl-5-[3-({2-methyl-1-oxo-1-[(1,3,4-thiadiazol-2-yl)amino]pro |
| 5PZP |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide (bms-929075) |
28430437 |
2.95 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 8XJ[4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-{[1-(pyrimidin-2-yl)cyclopropyl]ca |
| 5TRH |
EM |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid |
27908764 |
2.70 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 7HL[2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid] , SO4 |
| 5TRI |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)benzoic acid |
27908764 |
2.30 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 7HM[3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid] ,SO4 |
| 5TRJ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNAP in complex with 2-{[2-(carboxymethoxy)benzene-1-carbonyl]amino}-3-[(4-chlorophenyl)methoxy]benzoic acid |
27908764 |
2.57 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 7HO[2-{[2-(carboxymethoxy)benzene-1-carbonyl]amino}-3-[(4-chlorophenyl)methoxy]benzoic ac |
| 5TRK |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNA- dependent RNAP in complex with N-{3-[(benzenecarbonyl)amino]-4-[(4-chlorophenyl)methoxy]benzene-1-carbonyl}glycine |
27908764 |
2.06 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 7HH[N-{3-[(benzenecarbonyl)amino]-4-[(4-chlorophenyl)methoxy]benzene-1-carbonyl}glycine] |
| 5TWN |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of the hepatitis C virus NS5B RNA- dependent RNAP in complex with 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide |
30108798 |
3.04 Å |
RNAP |
RNAP (NS5B) |
23E[(2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid] , 7NG[ 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2, |
| 3FQQ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of a novel dimeric form of HCV NS5A domain L protein |
19244328 |
2.20 Å |
Subunit |
Non-Structural Protein 5a |
0BD[3-methyl-1-(2-methylpropyl)butyl 4-O-beta-L-gulopyranosyl-beta-D-glucopyranoside], GOL, ZN |
| 1ZH1 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of the zinc-binding domain of HCV NS5A |
15902263 |
2.50 Å |
Subunit |
Non-Structural Polyprotein |
ZN |
| 3FQL |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B (con1 1-570) with HCV-796 inhibitor |
19246450 |
1.80 Å |
RNAP |
RNAP |
79Z[5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide] , GOL |
| 3FQM |
XRD |
Virus |
Hepatitis C virus(HCV) |
Crystal structure of a novel dimeric form of HCV NS5A domain L protein |
19244328 |
1.90 Å |
Subunit |
Non-Structural Protein 5a |
GOL, ZN |
| 6GP9 |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structural studies of hepatitis C virus non-structural protein-5b of genotype 4a |
|
3.10 Å |
RNAP |
RNAP (NS5B) |
|
| 3HVO |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of the genotype 2b HCV polymerase bound to a nni |
To be published. |
2.00 Å |
RNAP |
RNAP (NS5B) |
VGI[2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione] |
| 3GSZ |
XRD |
Virus |
Hepatitis C virus(HCV) |
Structure of the genotype 2b HCV polymerase |
19505479 |
1.90 Å |
RNAP |
RNAP (NS5B) |
|
| 4CL1 |
XRD |
Virus |
Hepatitis C virus(HCV) |
The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors |
24639329 |
3.50 Å |
Subunit |
Non-Structural Protein 5a |
3K1??5-hydroxy-2-??4-(1H-tetrazol-5-yl)phenyl??pyrimidin-4(3H)-one?? SO4 MN |
| 2XI2 |
XRD |
Virus |
Hepatitis C virus(HCV) |
HCV-H77 NS5B apo polymerase |
20729191 |
1.80 Å |
RNAP |
RNAP (NS5B) |
SO4 |
| 6W4G |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus polymerase NS5B with ro inhibitor for sar studies |
33085891 |
1.95 Å |
RNAP |
RNAP (NS5B) |
SL4??5-[[(2~{S})-4-[1,1-bis(oxidanylidene)-1,2-benzothiazol-3-yl]-2-~{tert}-butyl-3-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]methyl]-2-fluoranyl-benzenecarbonitrile?? |
| 1YVF |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP complex with inhibitor pha-00729145 |
15863301 |
2.50 Å |
RNAP |
RNAP (NS5B) |
PH7??(2Z)-2-(BENZOYLAMINO)-3-[4-(2-BROMOPHENOXY)PHENYL]-2-PROPENOIC ACID?? PO4 GOL??GLYCEROL?? CL |
| 1Z4U |
XRD |
Virus |
Hepatitis C virus(HCV) |
Hepatitis C virus NS5B RNAP complex with inhibitor pha-00799585 |
15911260 |
2.80 Å |
RNAP |
RNAP (NS5B) |
PH9??(2Z)-2-??(1-ADAMANTYLCARBONYL)AMINO??-3-??4-(2-BROMOPHENOXY)PHENYL??PROP-2-ENOIC ACID?? PO4 GOL CL |
| 2M5L |
XRD |
Virus |
Hepatitis C virus(HCV) |
NS5A308 |
To be published. |
|
Subunit |
NS5A Protein |
|
| 4TLR |
XRD |
Virus |
Hepatitis C virus(HCV) |
NS5B in complex with lactam-thiophene carboxylic acids |
24986660 |
1.86 Å |
RNAP |
RNAP (NS5B) |
33H??3-{(2R,5R)-5-cyclohexyl-2-[(2R)-2-hydroxypropyl]-3-oxomorpholin-4-yl}-5-(3,3-dimethylbut-1-yn-1-yl)thiophene-2-carboxylic acid?? 79Z??5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide?? |
| 6U5O |
EM |
Virus |
Human metapneumovirus (HMPV) |
Structure of the human metapneumovirus polymerase bound to the phosphoprotein tetramer |
31698413 |
3.70 Å |
RNAP |
RNAP L, Phosphoprotein |
|
| 4UCJ |
XRD |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
3.26 Å |
Subunit |
RNAP L |
SO4, ZN |
| 4UCI |
XRD |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
2.21 Å |
RNAP |
RNAP L |
GTP[ Guanosine-5'-Triphosphate ], SAM[S-ADENOSYLMETHIONINE], ADN[ADENOSINE], GOL, ZN |
| 4UCK |
XRD |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
2.66 Å |
RNAP |
RNAP L |
SAM[S-ADENOSYLMETHIONINE], ZN |
| 4UCL |
XRD |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
2.80 Å |
RNAP |
RNAP L |
SO4, ZN |
| 4UCY |
EM |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
2.83 Å |
RNAP |
RNAP L |
SO4, ZN |
| 4UCZ |
XRD |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
2.99 Å |
RNAP |
RNAP L |
GTP[ Guanosine-5'-Triphosphate ], GMP[GUANOSINE], ZN |
| 4UD0 |
XRD |
Virus |
Human metapneumovirus (HMPV) |
X-ray structure and activities of an essential mononegavirales L- protein domain |
26549102 |
3.20 Å |
RNAP |
RNAP L |
SAH[S-ADENOSYL-L-HOMOCYSTEINE], SO4, ZN |
| 4NRT |
XRD |
Virus |
Human Norovirus(hNoV) |
Human norovirus polymerase bound to compound 6 (suramin derivative) |
24622391 |
2.02 Å |
RNAP |
RNAP |
2NG[4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid] , MG |
| 4LQ3 |
XRD |
Virus |
Human Norovirus(hNoV) |
Crystal structure of human norovirus RNAP bound to the inhibitor ppnds |
24316032 |
2.60 Å |
RNAP |
RNAP |
20V[3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid] , MG |
| 4LQ9 |
EM |
Virus |
Human Norovirus(hNoV) |
Crystal structure of human norovirus RNAP in complex with NAF2 |
24316032 |
2.04 Å |
RNAP |
RNAP |
21D[naphthalene-1,5-disulfonic acid] , MG |
| 6V85 |
XRD |
Virus |
Human parainfluenza virus (HPIVs) |
Parainfluenza virus 5 L-P complex |
32075920 |
4.38 Å |
RNAP |
RNAP L,Phosphoprotein |
ZN |
| 6V86 |
XRD |
Virus |
Human parainfluenza virus (HPIVs) |
Parainfluenza virus 5 L-P complex with an alternate conformation of the CD-MTase-CTD module |
32075920 |
4.63 Å |
RNAP |
RNAP L,Phosphoprotein |
ZN |
| 5I61 |
XRD |
Virus |
Human picobiRNAvirus(hPBV) |
Crystal structure of the RNAP of a human picorbiRNAvirus |
27078841 |
2.40 Å |
RNAP |
Potential RNAP |
|
| 5I62 |
XRD |
Virus |
Human picobiRNAvirus(hPBV) |
Crystal structure of the insertion loop deletion mutant of the RNAP of a human picorbiRNAvirus |
27078841 |
2.00 Å |
RNAP |
Potential RNAP |
|
| 3OL6 |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex |
21148772 |
2.50 Å |
EC |
RNAP |
ZN, IPA[ISOPROPYL ALCOHOL] |
| 3OL8 |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex with CTP-MN |
21148772 |
2.75 Å |
EC |
RNAP |
POP[2-pyrophosphate], GOL, ZN, IPA[ISOPROPYL ALCOHOL], MN |
| 3OL9 |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex with 3'-deoxy-CTP |
21148772 |
2.25 Å |
EC |
RNAP |
POP[2-pyrophosphate], ZN, IPA[ISOPROPYL ALCOHOL] |
| 3OLA |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex with 2'-deoxy-CTP |
21148772 |
2.55 Å |
EC |
RNAP |
DCP[2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE], PEG[ DI(HYDROXYETHYL)ETHER ], GOL, ZN, IPA[ISOPROPYL ALCOHOL] |
| 3OLB |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex with 2',3'-dideoxy-CTP |
21148772 |
2.41 Å |
EC |
RNAP |
DCT[2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE], ZN, IPA[ISOPROPYL ALCOHOL] |
| 1RA6 |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase full length apo structure |
15306852 |
2.00 Å |
RNAP |
RNAP |
ACY[ACETIC ACID] |
| 1RA7 |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase with GTP |
15306852 |
2.35 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ], ACY[ACETIC ACID] |
| 1RAJ |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase with a 68 residue N-terminal truncation |
15306852 |
2.50 Å |
Subunit |
N-terminal |
|
| 1RDR |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus 3D polymerase |
9309225 |
2.40 Å |
RNAP |
Poliovirus 3D Polymerase |
CA[ CALCIUM ION ] |
| 1TQL |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase G1A mutant |
15306852 |
2.30 Å |
RNAP |
RNAP |
ACY[ACETIC ACID], CAS[ACETIC ACID] |
| 2IJF |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of the poliovirus RNAP fidelity mutant 3D pol G64S |
17251299 |
3.00 Å |
RNAP |
RNAP |
|
| 2ILY |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of poliovirus polymerase complexed with ATP and MG2+ |
17223130 |
2.60 Å |
RNAP |
RNAP |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], ACY[ACETIC ACID], NA |
| 2ILZ |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of poliovirus polymerase complexed with GTP andMn2+ |
17223130 |
2.50 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ], ACY[ACETIC ACID], NA, MN |
| 2IM0 |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of poliovirus polymerase complexed with CTP and MG2+ |
17223130 |
2.25 Å |
RNAP |
RNAP |
CTP[ CYTIDINE-5'-TRIPHOSPHATE ], ACY[ACETIC ACID], NA |
| 2IM1 |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of poliovirus polymerase complexed with CTP andMn2+ |
17223130 |
2.50 Å |
RNAP |
RNAP |
CTP[ CYTIDINE-5'-TRIPHOSPHATE ], ACY[ACETIC ACID], NA, MN |
| 2IM2 |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of poliovirus polymerase complexed with UTP and MG2+ |
17223130 |
2.35 Å |
RNAP |
RNAP |
UTP[ URIDINE 5'-TRIPHOSPHATE ], ACY[ACETIC ACID], NA |
| 2IM3 |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of poliovirus polymerase complexed with UTP andMn2+ |
17223130 |
2.60 Å |
RNAP |
RNAP |
UTP[ URIDINE 5'-TRIPHOSPHATE ], ACY[ACETIC ACID], NA, MN |
| 3OL7 |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex with CTP |
21148772 |
2.70 Å |
EC |
RNAP |
POP[ PYROPHOSPHATE 2- ], PEG[ DI(HYDROXYETHYL)ETHER ], GOL, ZN, IPA[ISOPROPYL ALCOHOL], MG |
| 4K4U |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex (R5_form) |
23667424 |
2.85 Å |
EC |
RNAP |
SO4 |
| 4K4V |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex (R5+1_form) |
23667424 |
2.63 Å |
EC |
RNAP |
SO4 |
| 4K4W |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex (R5+2_form) |
23667424 |
2.69 Å |
EC |
RNAP |
|
| 4NLO |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - C290I loop mutant |
24424421 |
2.20 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLP |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - C290V loop mutant |
24424421 |
2.20 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLQ |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - C290F loop mutant |
24424421 |
2.30 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLR |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - C290S loop mutant |
24424421 |
2.00 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLS |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - S288A loop mutant |
24424421 |
2.00 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLT |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - S291P loop mutant |
24424421 |
2.50 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLU |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - G289A loop mutant |
24424421 |
2.10 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLV |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - G289A/C290F loop mutant |
24424421 |
2.30 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLW |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - G289A/C290I loop mutant |
24424421 |
2.10 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLX |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - G289A/C290V loop mutant |
24424421 |
2.60 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4NLY |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase - C290E loop mutant |
24424421 |
2.30 Å |
RNAP |
RNAP |
1PE[PENTAETHYLENE GLYCOL], ACY[ACETIC ACID], NA |
| 4R0E |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of the poliovirus RNAP low-fidelity mutant 3D pol H273R |
25378410 |
3.00 Å |
RNAP |
RNAP |
|
| 2IJD |
XRD |
Virus |
Human poliovirus(PV) |
Crystal structure of the poliovirus precursor protein 3CD |
17251299 |
3.40 Å |
RNAP |
PicoRNAn 3c, RNAP |
SO4, ZN |
| 4K4S |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex (r3_form) |
23667424 |
2.40 Å |
EC |
RNAP |
GOL, ZN |
| 4K4T |
XRD |
Virus |
Human poliovirus(PV) |
Poliovirus polymerase elongation complex (r4_form) |
23667424 |
2.75 Å |
EC |
RNAP |
GOL, ZN |
| 1TP7 |
XRD |
Virus |
Human rhinovirus(HRV) |
Crystal structure of the RNAP from human rhinovirus 16 |
15596823 |
2.40 Å |
RNAP |
RNAP |
DMX[3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE], SO4 |
| 1XR7 |
XRD |
Virus |
Human rhinovirus(HRV) |
Crystal structure of RNAP 3D from human rhinovirus serotype 16 |
15296746 |
2.30 Å |
RNAP |
RNAP |
|
| 4K50 |
XRD |
Virus |
Human rhinovirus(HRV) |
Rhinovirus 16 polymerase elongation complex (R1_form) |
23667424 |
2.93 Å |
RNAP |
RNAP |
SO4, GOL, ACT[ACETATE ION] |
| 1XR6 |
XRD |
Virus |
Human rhinovirus(HRV) |
Rystal structure of RNAP 3D from human rhinovirus serotype 1b |
15296746 |
2.50 Å |
RNAP |
RNAP |
K[POTASSIUM ION] |
| 1XR5 |
XRD |
Virus |
Human rhinovirus(HRV) |
Crystal structure of the RNAP 3D from human rhinovirus serotype 14 |
15296746 |
2.80 Å |
RNAP |
RNAP |
SM[SAMARIUM (III) ION] |
| 2PGG |
XRD |
Virus |
infectious bursal disease virus(IBDV) |
Crystal structure of a biRNAvirus (ibdv) RNAP VP1 |
17456597 |
2.50 Å |
RNAP |
RNAP |
|
| 2PUS |
XRD |
Virus |
infectious bursal disease virus(IBDV) |
Unprecedented activation mechanism of a non-canonical RNAP |
18077388 |
2.40 Å |
RNAP |
VP1 RNAP |
|
| 2QJ1 |
XRD |
Virus |
infectious bursal disease virus(IBDV) |
Crystal structure of infectious bursal disease virus VP1 polymerase incubated with an oligopeptide mimicking the VP3 c-terminus |
To be published. |
3.48 Å |
RNAP |
VP1 RNAP |
|
| 2R70 |
XRD |
Virus |
infectious bursal disease virus(IBDV) |
Crystal structure of infectious bursal disease virus VP1 polymerase, cocrystallized with an oligopeptide mimicking the VP3 c-terminus. |
18077388 |
2.70 Å |
RNAP |
VP1 RNAP |
|
| 2R72 |
XRD |
Virus |
infectious bursal disease virus(IBDV) |
Crystal structure of infectious bursal disease virus VP1 polymerase, incubated with MG2+ Ion. |
18077388 |
3.15 Å |
RNAP |
VP1 RNAP |
MG |
| 2YI8 |
XRD |
Virus |
infectious pancreatic necrosis virus(IPNV) |
Structure of the RNAP VP1 from infectious pancreatic necrosis virus |
21731487 |
2.30 Å |
RNAP |
VP1 RNAP |
K[POTASSIUM ION], CL |
| 2YI9 |
XRD |
Virus |
infectious pancreatic necrosis virus(IPNV) |
Structure of the RNAP VP1 from infectious pancreatic necrosis virus in complex with magnesium |
21731487 |
2.20 Å |
RNAP |
VP1 RNAP |
K[POTASSIUM ION], CL, MG |
| 2YIA |
XRD |
Virus |
infectious pancreatic necrosis virus(IPNV) |
Structure of the RNAP VP1 from infectious pancreatic necrosis virus |
21731487 |
3.02 Å |
RNAP |
VP1 RNAP |
K[POTASSIUM ION], CL |
| 2YIB |
XRD |
Virus |
infectious pancreatic necrosis virus(IPNV) |
Structure of the RNAP VP1 from infectious pancreatic necrosis virus |
21731487 |
3.80 Å |
RNAP |
VP1 RNAP |
|
| 3ZED |
XRD |
Virus |
infectious pancreatic necrosis virus(IPNV) |
X-ray structure of the biRNAvirus VP1-VP3 complex |
23283942 |
2.20 Å |
RNAP |
VP1 RNAP,Capsid Protein VP3 |
GOL, K[POTASSIUM ION] |
| 7NK4 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core |
35017564 |
5.32Å |
RNAP |
RNAP,Nanobody 8203 |
|
| 7NFQ |
XRD |
Virus |
Influenza A virus |
Fujian capmidlink domain in complex with Nb8193 |
35017564 |
1.68Å |
RNAP |
Polymerase basic protein 2,Nb8193 |
PEG,GOL |
| 7NFR |
XRD |
Virus |
Influenza A virus |
Fujian capmidlink domain in complex with Nb8194 |
35017564 |
1.88Å |
RNAP |
Polymerase basic protein 2,Nb8194 |
SO4,GOL |
| 7NHA |
XRD |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a) |
35017564 |
2.91Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A |
|
| 7NFT |
XRD |
Virus |
Influenza A virus |
Fujian capbinding domain in complex with Nb8208 |
35017564 |
3.14Å |
RNAP |
Polymerase basic protein 2,Nb8208 |
SO4 |
| 7NHX |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1) |
35017564 |
3.23Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A |
|
| 7NHX |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1) |
35017564 |
3.23Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A |
|
| 7NI0 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer - Replicase (class 3) |
35017564 |
3.32Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A |
|
| 7NIK |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core |
35017564 |
6.20Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NIL |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core |
35017564 |
5.01Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NIR |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core |
35017564 |
6.70Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NIS |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core |
35017564 |
5.96Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NJ3 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core |
35017564 |
4.48Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NJ4 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core |
35017564 |
5.84Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NJ5 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core |
35017564 |
4.63Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8189 core |
|
| 7NJ7 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core |
35017564 |
4.82Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nb8200 core |
|
| 7NK1 |
EM |
Virus |
Influenza A virus |
1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201 |
35017564 |
4.22Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8201 |
|
| 7NK2 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core |
35017564 |
4.84Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8202 |
|
| 7NK4 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core |
35017564 |
5.32Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8203 |
|
| 7NK6 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204 |
35017564 |
6.72Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nb8204 |
|
| 7NIL |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core |
35017564 |
5.01Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8190 core |
|
| 7NIR |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core |
35017564 |
6.70 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8191 core |
|
| 7NIS |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core |
35017564 |
5.96Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8192 core |
|
| 7NJ3 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core |
35017564 |
4.48 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8192 core |
|
| 7NJ4 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core |
35017564 |
5.84Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8198 core |
|
| 7NJ5 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core |
35017564 |
4.63Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8198 core |
|
| 7NJ7 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core |
35017564 |
4.82Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nb8200 core |
|
| 7NK1 |
EM |
Virus |
Influenza A virus |
1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201 |
35017564 |
4.22Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8201 |
|
| 7NK2 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core |
35017564 |
4.84Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8202 |
|
| 7NK4 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core |
35017564 |
5.32Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8203 |
|
| 7NK6 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204 |
35017564 |
6.72 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8204 |
|
| 7NK8 |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8205 core |
35017564 |
5.34Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8205 |
|
| 7NKA |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206 |
35017564 |
4.07Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8206 |
|
| 7NKC |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207 |
35017564 |
4.46Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nanobody8207 |
|
| 7NKI |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core |
35017564 |
4.47Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nb8209 |
|
| 7NKR |
EM |
Virus |
Influenza A virus |
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8210 |
35017564 |
5.60Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,Immunoglobulin G-binding protein A,Nb8210 |
|
| 7ZPM |
EM |
Virus |
Influenza A virus |
Influenza A/H7N9 polymerase apo-protein dimer complex |
36596301 |
2.81 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
|
| 7QTL |
EM |
Virus |
Influenza A virus |
Influenza A/H7N9 polymerase elongation complex |
36596301 |
2.48 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],2TM[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine],MG |
| 7R0E |
EM |
Virus |
Influenza A virus |
Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position |
36596301 |
2.51 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],MG |
| 7ZPL |
EM |
Virus |
Influenza A virus |
Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook |
36596301 |
3.12 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
MG |
| 8BEK |
EM |
Virus |
Influenza A virus |
Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position |
36596301 |
2.86 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],MG |
| 7ZPY |
XRD |
Virus |
Influenza A virus |
Influenza polymerase A C-terminal domain of PA subunit with optimized small peptide inhibitor |
36265804 |
1.90 Å |
Domain |
Polymerase acidic protein,Peptide inhibitor |
MOE[METHOXY-ETHOXYL] |
| 7N47 |
XRD |
Virus |
Influenza A virus |
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 |
36603507 |
2.37 Å |
Domain |
Polymerase acidic protein |
QQ4[Hexa Vinylpyrrolidone K15],09Y[5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide],SO4[SULFATE ION],MN |
| 7N55 |
XRD |
Virus |
Influenza A virus |
The crystal structure of the mutant I38T PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 |
36603507 |
2.33 Å |
Domain |
Polymerase acidic protein |
QQ4[Hexa Vinylpyrrolidone K15],09Y[5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide],SO4[SULFATE ION],MN |
| 7RKP |
XRD |
Virus |
Influenza A virus |
The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 |
36603507 |
2.36 Å |
Domain |
Polymerase acidic protein |
QQ4[Hexa Vinylpyrrolidone K15],5Y1[(5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione],SO4[SULFATE ION],MN |
| 7V04 |
XRD |
Virus |
Influenza A virus |
The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide |
36655124 |
1.91 Å |
Domain |
Polymerase acidic protein |
PQO[6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide],MN |
| 8CTF |
XRD |
Virus |
Influenza A virus |
The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
36655124 |
2.14 Å |
Domain |
Polymerase acidic protein |
Q3O[ 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid],ACT[ACETATE ION],MN |
| 8DDB |
XRD |
Virus |
Influenza A virus |
The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid |
36655124 |
2.15 Å |
Domain |
Polymerase acidic protein |
R6X[6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid],SO4[ SULFATE ION],ACT[ACETATE ION],MN |
| 7MTY |
XRD |
Virus |
Influenza A virus (A/California/04/2009(H1N1)) |
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569 |
36603507 |
2.38 Å |
Domain |
Polymerase acidic protein |
QQ4[Hexa Vinylpyrrolidone K15],W5V[ 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide],SO4[SULFATE ION],MN |
| 7N68 |
XRD |
Virus |
Influenza A virus (A/California/04/2009(H1N1)) |
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288 |
|
2.26 Å |
Domain |
Polymerase acidic protein,Polymerase acidic protein |
QQ4[Hexa Vinylpyrrolidone K15],0VL[ benzyl {2-[(5S)-5-hydroxy-4-oxo-6-{[2-(pyridin-4-yl)ethyl]carbamoyl}-4,5-dihydropyrimidin-2-yl]propan-2-yl}carbamate],SO4[SULFATE ION],MN |
| 7Z4O |
XRD |
Virus |
Influenza A virus, Homo sapiens |
Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A |
35605026 |
3.41 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
MG |
| 6QNW |
XRD |
Virus |
Influenza A virus(FluA) |
influenza A polymerase heterotrimer human H3N2 northern territory 1968 |
31485076 |
3.31 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6QPG |
XRD |
Virus |
Influenza A virus(FluA) |
influenza A virus polymerase heterotrimer a/nt/60/1968(H3N2) in complex with nanobody NB8205 |
31485076 |
3.34 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Nanobody NB8205 |
|
| 6QX8 |
EM |
Virus |
Influenza A virus(FluA) |
influenza A virus (A/nt/60/1968) polymerase dimer of heterotrimer in complex with 5' cRNA promoter |
31485076 |
4.07 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6QXE |
EM |
Virus |
Influenza A virus(FluA) |
influenza A virus (A/nt/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' cRNA promoter and NB8205 |
31485076 |
4.15 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,NB8205 |
|
| 6RR7 |
EM |
Virus |
Influenza A virus(FluA) |
influenza A virus (A/nt/60/1968) polymerase heterotrimer bound to 3'5' vRNA promoter and capped RNA primer |
31485076 |
3.01 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6QX3 |
EM |
Virus |
Influenza A virus(FluA) |
influenza A virus (A/nt/60/1968) polymerase hetermotrimer in complex with 3'5' cRNA promoter and NB8205 |
31485076 |
3.79 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,NB8205 |
|
| 6QPF |
XRD |
Virus |
Influenza A virus(FluA) |
influenza A virus polymerase heterotrimer A/duck/fujian/01/2002(H5N1) |
31485076 |
3.63 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 4NFZ |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10 |
24284327 |
2.70 Å |
Subunit |
Polymerase PA |
MN |
| 4WSB |
XRD |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase with bound vRNA promoter |
25409151 |
2.65 Å |
RNAP |
Polymerase PA,RNAP Catalytic Subunit,Polymerase PB2 |
PO4, ZN |
| 5M3H |
XRD |
Virus |
Influenza A virus(FluA) |
Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated pol II CTD |
28002402 |
2.50 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Tyr-Ser-Pro-Thr-Sep-Pro |
PO4, ZN |
| 6EVJ |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer |
29202182 |
3.90 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6EVK |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP |
29202182 |
2.90 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MGP[7-METHYL-GUANOSINE-5'-TRIPHOSPHATE] , PO4, ZN |
| 6FHH |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified pol II CTD peptide with serine 5 thiophosphorylated. |
To be published. |
2.70 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
PO4, ZN |
| 6FHI |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated pol II CTD peptide with a truncated linker. |
To be published. |
2.80 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
PO4, ZN |
| 6SZU |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence |
32304664 |
2.41 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], POP[ PYROPHOSPHATE 2- ], MG |
| 6SZV |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) |
32304664 |
2.50 Å |
EC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uri], M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], MG |
| 6T0N |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase pre-initiation complex |
32304664 |
2.54 Å |
pIC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 6T0R |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase product dissociation complex using 44-mer vRNA template with mutated oligo(U) sequence |
32304664 |
2.82 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6T0S |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence |
32304664 |
3.04 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 6T0U |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence |
32304664 |
3.12 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6T0V |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) |
32304664 |
3.02 Å |
EC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine], M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], MG |
| 6T2C |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase recycling complex |
32304664 |
3.52 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 6TW1 |
EM |
Virus |
Influenza A virus(FluA) |
Bat influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence |
32304664 |
2.70 Å |
TC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
M4H[5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid], POP[ PYROPHOSPHATE 2- ], MG |
| 4IUJ |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of polymerase acid protein (PA) from influenzavirus a influenza A virus A, wilson-smith/1933 (H1N1) |
25089892 |
1.90 Å |
RNAP |
Polymerase Acidic Protein |
|
| 5IEQ |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-747 1-(4-chlorophenyl)-1H-imidazole |
To be published. |
2.20 Å |
RNAP |
Polymerase Acidic Protein |
1CI[1-(4-CHLOROPHENYL)-1H-IMIDAZOLE] , DMS[DIMETHYL SULFOXIDE] |
| 5IF2 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-576 (5,6-dichloro-1H-1,3-benzodiazol-2-yl)methanol |
To be published. |
2.35 Å |
RNAP |
Polymerase Acidic Protein |
6B1[(5,6-dichloro-1H-benzimidazol-2-yl)methanol] , DMS[DIMETHYL SULFOXIDE], CL |
| 5IF5 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol |
To be published. |
2.25 Å |
RNAP |
Polymerase Acidic Protein |
6B0[(2,3-dichlorophenyl)methanol], DMS[DIMETHYL SULFOXIDE], EDO[1,2-ETHANEDIOL] |
| 5IF7 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
To be published. |
2.65 Å |
RNAP |
Polymerase Acidic Protein |
6AY[N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine] , DMS[DIMETHYL SULFOXIDE] |
| 5IF8 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine |
To be published. |
2.30 Å |
RNAP |
Polymerase Acidic Protein |
6AX[5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine] , GOL, DMS[DIMETHYL SULFOXIDE], EDO[1,2-ETHANEDIOL], CL |
| 5IFB |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4719 5-chloro-2-(1h-imidazol-1-yl)aniline |
To be published. |
2.45 Å |
RNAP |
Polymerase Acidic Protein |
6AV[5-chloro-2-(1H-imidazol-1-yl)aniline] , DMS[DIMETHYL SULFOXIDE], CL |
| 5IFC |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4720 1-(4-bromophenyl)-1H-imidazole |
To be published. |
2.65 Å |
RNAP |
Polymerase Acidic Protein |
6AR[1-(4-bromophenyl)-1H-imidazole] , DMS[DIMETHYL SULFOXIDE] |
| 5IFD |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4721 1-(4-fluorophenyl)-1H-imidazole |
To be published. |
2.65 Å |
RNAP |
Polymerase Acidic Protein |
6AQ[1-(4-fluorophenyl)-1H-imidazole] , DMS[DIMETHYL SULFOXIDE] |
| 5V0U |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to follow on fragment EBSI-4723 4-(5-chlorothiophen-2-yl)-1H-pyrazole |
To be published. |
2.45 Å |
RNAP |
Polymerase Acidic Protein |
8QG[4-(5-chlorothiophen-2-yl)-1H-pyrazole] |
| 6CFP |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase acid protein (PA) from influenza A virus, wilson-smith/1933 (H1N1) bound to fragment hit bsi-70565 1-{1-[4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one |
To be published. |
2.45 Å |
RNAP |
Ubiquitin-Like Protein Smt3,Polymerase Acidic Protein |
EZS[1-{1-[(4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one] , DMS[DIMETHYL SULFOXIDE] |
| 4AVG |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2 |
22876177 |
2.20 Å |
Subunit |
Polymerase PA |
SL6 [(Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid] , MN |
| 4AVL |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with dTMP |
22876177 |
1.87 Å |
Subunit |
Polymerase PA |
TMP[THYMIDINE-5'-PHOSPHATE] , MN |
| 4AVQ |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease |
22876177 |
2.10 Å |
Subunit |
Polymerase PA |
MN, MG |
| 4AWF |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2 4-dioxo-4-phenylbutanoic acid dpba |
22876177 |
2.30 Å |
RNAP |
Polymerase PA |
XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID] , MN |
| 4AWG |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3 |
22876177 |
2.60 Å |
Subunit |
Polymerase PA |
CI3[(2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid] , SO4, MN |
| 4AWH |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with RUMP |
22876177 |
2.05 Å |
Subunit |
Polymerase PA |
U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN |
| 4AWK |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1 |
22876177 |
1.90 Å |
Subunit |
Polymerase PA |
CI1[(2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid] , MN |
| 4AWM |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea |
22876177 |
2.60 Å |
Subunit |
Polymerase PA |
KDH[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate] , MN |
| 5CCY |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease in complex with dTMP |
26976575 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
TMP[THYMIDINE-5'-PHOSPHATE] , MN |
| 5CGV |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease in complex with l-742,001 |
26976575 |
2.17 Å |
Subunit |
Polymerase Acidic Protein |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , GOL, MN |
| 5CL0 |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease in complex with rUMP |
26976575 |
2.22 Å |
Subunit |
Polymerase Acidic Protein |
U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN |
| 5CZN |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant E119D |
26976575 |
1.98 Å |
Subunit |
Polymerase Acidic Protein |
SO4, MN |
| 5D2O |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant F105S |
26976575 |
2.15 Å |
Subunit |
Polymerase Acidic Protein |
MN |
| 5D42 |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant F105S in complex with dTMP |
26976575 |
2.00 Å |
Subunit |
Polymerase Acidic Protein |
TMP[THYMIDINE-5'-PHOSPHATE] , MN |
| 5D4G |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant F105S in complex with RUMP |
26976575 |
2.08 Å |
Subunit |
Polymerase Acidic Protein |
U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN |
| 5D8U |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant E119D in complex with l-742,001 |
26976575 |
2.29 Å |
Subunit |
Polymerase Acidic Protein |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , MN |
| 5D9J |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant F105S in complex with l-742,001 |
26976575 |
1.85 Å |
Subunit |
Polymerase Acidic Protein |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , MN |
| 5DBS |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant E119D in complex with dTMP |
26976575 |
2.11 Å |
Subunit |
Polymerase Acidic Protein |
TMP[THYMIDINE-5'-PHOSPHATE] , SO4,MN |
| 5DEB |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease mutant E119D in complex with rUMP |
26976575 |
2.14 Å |
Subunit |
Polymerase Acidic Protein |
U5P[ URIDINE-5'-MONOPHOSPHATE ] , MN |
| 5DES |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease domain |
26976575 |
2.05 Å |
Subunit |
Polymerase Acidic Protein |
MN |
| 5EGA |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease domain in complex with an N-acylhydrazone inhibitor |
27510745 |
2.15 Å |
Subunit |
Polymerase Acidic Protein |
GK0[3,4,5-tris(oxidanyl)-~{N}-[(~{E})-[3,4,5-tris(oxidanyl)phenyl]methylideneamino]benzamide] , MN |
| 5VP8 |
XRD |
Virus |
Influenza A virus(FluA) |
I38T mutant of 2009 H1N1 PA endonuclease |
29691337 |
2.20 Å |
Subunit |
Polymerase Acidic Protein |
9HD(1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one), SO4,MN |
| 5VPT |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease in complex with RO-7 |
29691337 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN |
| 5VPX |
XRD |
Virus |
Influenza A virus(FluA) |
I38T mutant of 2009 H1N1 PA endonuclease in complex with RO-7 |
29691337 |
2.30 Å |
Subunit |
Polymerase Acidic Protein |
R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN |
| 5VQN |
XRD |
Virus |
Influenza A virus(FluA) |
E119d mutant of 2009 H1N1 PA endonuclease in complex with RO-7 |
29691337 |
2.00 Å |
Subunit |
Polymerase Acidic Protein |
R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN |
| 5VRJ |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease in complex with RO-7 and magnesium |
29691337 |
2.30 Å |
Subunit |
Polymerase Acidic Protein |
R07[1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione] , SO4,MN |
| 5W3I |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6e (SRI-29685) |
29215062 |
1.95 Å |
Subunit |
Polymerase Acidic Protein |
GY5[5-hydroxy-N-(2-methoxyethyl)-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxamide] , GOL, MN |
| 5W44 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7a (SRI-29770) |
29215062 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
GY6[2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , MN, MG, NA |
| 5W73 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9f (SRI-29835) |
29215062 |
2.20 Å |
Subunit |
Polymerase Acidic Protein |
GY9[2-{(2S)-1-[(2-chlorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5W7U |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 8f (SRI-29928) |
29215062 |
2.20 Å |
Subunit |
Polymerase Acidic Protein |
GY8[2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-N-(2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1,6-dihydropy rimidine-4-carboxamide] , MN |
| 5W92 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30049 |
29215062 |
2.30 Å |
Subunit |
Polymerase Acidic Protein |
KU0 [2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide), 9HD[1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one], MN |
| 5W9G |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9k (SRI-30023) |
29215062 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
KU2[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4 -carboxamide] , SO4, MN, CL |
| 5WA6 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30007 |
29215062 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
KU7[2-{(2S)-1-[(2-fluorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , MN |
| 5WA7 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9b (SRI-30101) |
29215062 |
2.20 Å |
Subunit |
Polymerase Acidic Protein |
KU4[2-{(2S)-1-[3-(2-chlorophenyl)propanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WAP |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10i (SRI-30025) |
29215062 |
2.20 Å |
Subunit |
Polymerase Acidic Protein |
KU9[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WB3 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10j (SRI-30026) |
29215062 |
2.20 Å |
Subunit |
Polymerase Acidic Protein |
GYA[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WCS |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6b (SRI-29789) |
29215062 |
2.52 Å |
Subunit |
Polymerase Acidic Protein |
9KU[5-hydroxy-2-[(2S)-1-{[(naphthalen-1-yl)oxy]acetyl}pyrrolidin-2-yl]-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , MN |
| 5WCT |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6c (SRI-29775) |
29215062 |
2.30 Å |
Subunit |
Polymerase Acidic Protein |
GY4[2-{(2S)-1-[(4-chlorophenyl)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , MN |
| 5WDC |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 9e (SRI-29843) |
29215062 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
G2K[2-{(2S)-1-[(2-chlorophenoxy)acetyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WDN |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6d (SRI-29680) |
29215062 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
G1K[5-hydroxy-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxylic acid] , MN |
| 5WDW |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10k (SRI-30027) |
29215062 |
2.30 Å |
Subunit |
Polymerase Acidic Protein |
8KU[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-{[(2S)-2,3-dihydro-1-benzofuran-2-yl]methyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide] , MN |
| 5WE7 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-29782 |
To be published. |
2.12 Å |
Subunit |
Polymerase Acidic Protein |
G3K[2-{(2R)-1-[2-(4-chlorophenoxy)-2-methylpropanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , MLT[D-MALATE], MN |
| 5WE9 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 7b (SRI-29731) |
29215062 |
1.80 Å |
Subunit |
Polymerase Acidic Protein |
GY7[2-[(2S)-1-(2,6-difluorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , EDO[1,2-ETHANEDIOL], MN, MG |
| 5WEB |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10e (SRI-30024) |
29215062 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
KU5[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WEF |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (f105s mutant) in complex with inhibitor 7a (SRI-29770) |
29215062 |
2.00 Å |
Subunit |
Polymerase Acidic Protein |
GY6[2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , EDO[1,2-ETHANEDIOL], MN, NA |
| 5WEI |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 7a (SRI-29770) |
29215062 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
GY6[2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WF3 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 9k (SRI-30023) |
29215062 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
KU2[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4 -carboxamide] , SO4, MN |
| 5WFM |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 10e (SRI-30024) |
29215062 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
KU5[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WFW |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 10j (SRI-30026) |
29215062 |
2.29 Å |
Subunit |
Polymerase Acidic Protein |
GYA[2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 5WFZ |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 8e (SRI-30049) |
29215062 |
2.35 Å |
Subunit |
Polymerase Acidic Protein |
KU0[2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide] , SO4, GOL, MN |
| 5WG9 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the influenza virus PA endonuclease (e119d mutant) in complex with inhibitor 9b (SRI-30101) |
29215062 |
2.30 Å |
Subunit |
Polymerase Acidic Protein |
KU4[2-{(2S)-1-[3-(2-chlorophenyl)propanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide] , SO4, MN |
| 6DCY |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 5-hydroxy-2-methyl-4-oxo-4h-pyran-3-carboxylic acid |
30351002 |
2.08 Å |
Subunit |
Polymerase Acidic Protein |
G5V[5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid] , MN |
| 6DCZ |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-4h-pyran-2-carboxylic acid |
30351002 |
2.89 Å |
Subunit |
Polymerase Acidic Protein |
G5Y[3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid] , MN |
| 6DZQ |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-4h-pyran-2-carboxylic acid |
30351002 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
HJP[3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN |
| 6E0Q |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid |
30351002 |
2.35 Å |
Subunit |
Polymerase Acidic Protein |
HKD[4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN |
| 6E3M |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
2.65 Å |
Subunit |
Polymerase Acidic Protein |
HOG[6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN |
| 6E3N |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-4-oxo-6-(o-tolyl)-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
3.19 Å |
Subunit |
Polymerase Acidic Protein |
HNS[3-hydroxy-6-(2-methylphenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , MN |
| 6E3O |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(2-ethylphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
3.19 Å |
Subunit |
Polymerase Acidic Protein |
HNY[6-(2-ethylphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , MN |
| 6E3P |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-(1h-tetrazol-5-yl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
2.80 Å |
Subunit |
Polymerase Acidic Protein |
HO1[3-hydroxy-4-oxo-6-[3-(1H-tetrazol-5-yl)phenyl]-1,4-dihydropyridine-2-carboxylic acid] , MN |
| 6E4C |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-(2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
2.35 Å |
Subunit |
Polymerase Acidic Protein |
HRJ[3-hydroxy-6-[2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN |
| 6E6V |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
2.25 Å |
Subunit |
Polymerase Acidic Protein |
HWA[3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , EDO[1,2-ETHANEDIOL], MN |
| 6E6W |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-(2-methyl-4-(1h-tetrazol-5-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid |
31536340 |
2.35 Å |
Subunit |
Polymerase Acidic Protein |
HWJ[3-hydroxy-6-[2-methyl-4-(1H-tetrazol-5-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid] , MN |
| 6E6X |
XRD |
Virus |
Influenza A virus(FluA) |
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 1-(4-(1h-tetrazol-5-yl)phenyl)-5-hydroxy-2-methylpyridin-4(1h)-one |
31536340 |
2.50 Å |
Subunit |
Polymerase Acidic Protein |
HWM[5-hydroxy-2-methyl-1-[4-(1H-tetrazol-5-yl)phenyl]pyridin-4(1H)-one] , EDO[1,2-ETHANEDIOL], MN |
| 6FS6 |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza A/california/04/2009 (pH1N1) endonuclease with bound inhibitor, baloxavir acid (bxa) |
29941893 |
2.29 Å |
Subunit |
Polymerase Acidic Protein |
E4Z[Baloxavir acid] , MN |
| 6FS7 |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza A/california/04/2009 (pH1N1) endonuclease with I38T mutation with bound inhibitor, baloxavir acid (bxa) |
29941893 |
1.96 Å |
Subunit |
Polymerase Acidic Protein |
E4Z(Baloxavir acid) , MN |
| 2ZNL |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of PA-PB1 complex form influenza virus RNAP |
18660801 |
2.30 Å |
Subunit |
Polymerase Acidic Protein,RNAP Catalytic Subunit |
|
| 2ZTT |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of RNAP PB1-PB2 subunits from influenza A virus |
19461581 |
2.10 Å |
Subunit |
RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 3A1G |
XRD |
Virus |
Influenza A virus(FluA) |
High-resolution crystal structure of RNAP PB1-PB2 subunits from influenza A virus |
19461581 |
1.70 Å |
Subunit |
RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 2GMO |
SOLUTION NMR |
Virus |
Influenza A virus(FluA) |
NMR-structure of an independently folded C-terminal domain of influenza polymerase subunit PB2 |
17310249 |
|
Subunit |
Polymerase Basic Protein 2 |
|
| 2JDQ |
XRD |
Virus |
Influenza A virus(FluA) |
C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human Importin alpha5 |
17310249 |
2.20 Å |
Subunit |
Importin Alpha-1 Subunit,Polymerase Basic Protein 2 |
|
| 2VQZ |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP |
18454157 |
2.30 Å |
Subunit |
Polymerase Basic Protein 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] |
| 2VY6 |
XRD |
Virus |
Influenza A virus(FluA) |
Two domains from the C-terminal region of influenza A virus polymerase PB2 subunit |
18769709 |
1.95 Å |
Subunit |
Polymerase Basic Protein 2 |
|
| 2VY7 |
XRD |
Virus |
Influenza A virus(FluA) |
The 627-domain from influenza A virus polymerase PB2 subunit |
18769709 |
1.53 Å |
Subunit |
Polymerase Basic Protein 2 |
|
| 2VY8 |
XRD |
Virus |
Influenza A virus(FluA) |
The 627-domain from influenza A virus polymerase PB2 subunit with glu- 627 |
18769709 |
1.20 Å |
Subunit |
Polymerase Basic Protein 2 |
|
| 4NCE |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza polymerase basic protein 2 (PB2) bound to 7-methyl-gtp |
25019388 |
2.30 Å |
Subunit |
Polymerase Basic Protein 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] , 11H[9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid] |
| 4NCM |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza polymerase basic protein 2 (PB2) bound to a small-molecule inhibitor |
25019388 |
2.82 Å |
Subunit |
Polymerase Basic Protein 2 |
704[N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide] |
| 4P1U |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza A (flu) virus polymerase basic protein 2 (PB2) bound to VX787, an azaindole inhibitor |
25019388 |
2.52 Å |
Subunit |
Polymerase Basic Protein 2 |
21G[(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] |
| 4UAD |
XRD |
Virus |
Influenza A virus(FluA) |
Importin alpha 7 delta IBB in complex with influenza PB2 nuclear localization domain |
25599645 |
2.42 Å |
Subunit |
Importin Subunit Alpha-7,Polymerase Basic Protein 2 |
|
| 4UAE |
XRD |
Virus |
Influenza A virus(FluA) |
Importin alpha 3 delta IBB in complex with influenza PB2 nuclear localization domain |
25599645 |
2.70 Å |
Subunit |
Importin Subunit Alpha-3,Polymerase Basic Protein 2 |
SO4 |
| 4UAF |
XRD |
Virus |
Influenza A virus(FluA) |
Importin alpha 1 delta IBB in complex with influenza PB2 nuclear localization domain |
25599645 |
1.70 Å |
Subunit |
Importin Subunit Alpha-1,Polymerase Basic Protein 2 |
PO4 |
| 6EUV |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (vx-787) |
29202182 |
2.70 Å |
Subunit |
Polymerase Basic Protein 2 |
21G[(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , NI |
| 6EUY |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor |
29202182 |
3.00 Å |
Subunit |
Polymerase Basic Protein 2 |
BYB[(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , SO4 |
| 6TU5 |
XRD |
Virus |
Influenza A virus(FluA) |
influenza A/H7N9 polymerase core (apo) |
32304664 |
3.33 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 3CM8 |
XRD |
Virus |
Influenza A virus(FluA) |
A RNAP subunit structure from virus |
18615018 |
2.90 Å |
RNAP |
Polymerase Acidic Protein,Peptide From RNAP Catalytic Subunit |
|
| 3J9B |
XRD |
Virus |
Influenza A virus(FluA) |
Electron cryo-microscopy of an RNAP |
25620561 |
4.30 Å |
RNAP |
Polymerase,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 2W69 |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza polymerase fragment |
19194459 |
2.05 Å |
RNAP |
Polymerase Acidic Protein |
SO4, MN |
| 3EBJ |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of an avian influenza virus protein |
19194458 |
2.20 Å |
RNAP |
Polymerase Acidic Protein |
MG |
| 3HW3 |
XRD |
Virus |
Influenza A virus(FluA) |
The crystal structure of avian influenza virus PA_N in complex with UMP |
19587036 |
1.90 Å |
Subunit |
Polymerase Acidic Protein |
U5P[ URIDINE-5'-MONOPHOSPHATE ], MG |
| 3HW4 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza A virus in complex with TMP |
19587036 |
1.90 Å |
Subunit |
Polymerase Acidic Protein |
TMP[THYMIDINE-5'-PHOSPHATE], MG |
| 3HW5 |
EM |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pa_n in complex with AMP |
19587036 |
1.81 Å |
RNAP |
Polymerase Acidic Protein |
AMP[ADENOSINE MONOPHOSPHATE], MG |
| 3HW6 |
EM |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pa_n in complex with Mn |
19587036 |
2.50 Å |
Subunit |
Polymerase Acidic Protein |
MN |
| 6SYI |
XRD |
Virus |
Influenza A virus(FluA) |
C-terminal domain of influenza polymerase PA subunit and optimized small peptide inhibitor |
33166574 |
1.60 Å |
RNAP |
Polymerase Acidic Protein,Pb1-11 |
PGE[TRIETHYLENE GLYCOL], EDO[1,2-ETHANEDIOL] |
| 3CW4 |
XRD |
Virus |
Influenza A virus(FluA) |
Large C-terminal domain of influenza A virus RNA-dependent polymerase PB2 |
19144639 |
2.70 Å |
RNAP |
Polymerase Basic Protein 2 |
|
| 3WI0 |
EM |
Virus |
Influenza A virus(FluA) |
P453H/I471T mutant of PB2 middle domain from influenza virus a/puerto rico/8/34(H1N1) |
24312396 |
2.00 Å |
RNAP |
Polymerase Basic Protein 2 |
|
| 3WI1 |
EM |
Virus |
Influenza A virus(FluA) |
P453H/I471T mutant of PB2 middle domain from influenza virus a/puerto rico/8/34(H1N1) with m7GTP |
24312396 |
1.93 Å |
RNAP |
Polymerase Basic Protein 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] |
| 4ENF |
EM |
Virus |
Influenza A virus(FluA) |
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus a/puerto rico/8/34(H1N1) |
23436652 |
1.32 Å |
RNAP |
Polymerase Basic Protein 2 |
BU1[1,4-BUTANEDIOL], NO3[NITRATE ION] |
| 4J2R |
EM |
Virus |
Influenza A virus(FluA) |
Middle domain of influenza A virus RNA-dependent polymerase PB2 |
24419622 |
2.42 Å |
RNAP |
Polymerase Basic Protein 2 |
|
| 4U6O |
EM |
Virus |
Influenza A virus(FluA) |
Structure of the cap-binding domain of influenza virus polymerase subunit PB2 |
To be published. |
1.30 Å |
RNAP |
Polymerase Basic Protein 2 |
PO4 |
| 4EQK |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (H3N2) with bound m7GTP |
23436652 |
1.95 Å |
Subunit |
Polymerase Basic Protein 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], NO3[NITRATE ION] |
| 3KC6 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the large C-terminal domain of polymerase basic protein 2 from influenza virus A/Vietnam/1203/2004 (H5N1) |
20700447 |
2.05 Å |
RNAP |
Polymerase PB2 |
EDO[1,2-ETHANEDIOL], ZN |
| 3L56 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the large C-terminal domain of polymerase basic protein 2 from influenza virus A/Vietnam/1203/2004 (H5N1) |
20700447 |
2.30 Å |
RNAP |
Polymerase PB2 |
|
| 5FMM |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to m7GTP |
26711008 |
2.40 Å |
Subunit |
influenza A PB2 Subunit |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], FLC[CITRATE ANION] |
| 5FMQ |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to m7GTP h32 crystal form |
26711008 |
3.10 Å |
RNAP |
influenza A PB2 Subunit |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] |
| 5JUR |
XRD |
Virus |
Influenza A virus(FluA) |
PB2 bound to an azaindole inhibitor |
28197322 |
2.93 Å |
Subunit |
Polymerase Basic Protein 2 |
6NS[(3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethyl-pentanoic acid] |
| 44717 |
XRD |
Virus |
Influenza A virus(FluA) |
PB2 bound to an azaindole inhibitor |
28197322 |
2.69 Å |
Subunit |
Polymerase Basic Protein 2 |
6NU[(3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-3-(1-methylcyclobutyl)propanoic acid] |
| 5F79 |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza PB2 bound to an azaindole inhibitor |
28197323 |
2.40 Å |
Subunit |
Polymerase Basic Protein 2 |
4V7[N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide] |
| 5BUH |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza PB2 bound to a hydroxymethyl azaindole inhibitor |
28197323 |
2.55 Å |
Subunit |
Polymerase Basic Protein 2 |
4V7[N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide] |
| 4YD0 |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor |
25827523 |
2.62 Å |
Subunit |
Polymerase Basic Protein 2 |
4EW[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine] |
| 4ES5 |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus a/bar-headed gs/qinghai/15c/2005 (H5N1) with bound m7GTP |
23436652 |
1.80 Å |
Subunit |
Polymerase Basic Subunit 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], SO4 |
| 5EG9 |
XRD |
Virus |
Influenza A virus(FluA) |
The cap binding site of influenza virus protein PB2 as a drug target |
26894672 |
2.30 Å |
Subunit |
Polymerase Basic Protein 2 |
|
| 5WL0 |
XRD |
Virus |
Influenza A virus(FluA) |
Co-crystal structure of influenza A H3N2 PB2 (241-741) bound to vx-787 |
28839261 |
2.40 Å |
Subunit |
Polymerase Basic Protein 2 |
21G[(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , PEG[ DI(HYDROXYETHYL)ETHER ] |
| 4CB4 |
XRD |
Virus |
Influenza A virus(FluA) |
Of influenza A H5N1 PB2 cap-binding domain with bound m7GTP |
24134208 |
1.60 Å |
Subunit |
Polymerase Basic Subunit 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE], CL |
| 4CB5 |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f) |
24134208 |
1.50 Å |
Subunit |
Polymerase Basic Subunit 2 |
93G[9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE] , CL |
| 4CB6 |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11) |
24134208 |
1.90 Å |
Subunit |
Polymerase Basic Subunit 2 |
29R[2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE] , IOD[IODIDE ION] |
| 4CB7 |
XRD |
Virus |
Influenza A virus(FluA) |
Structure of influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e) |
24134208 |
1.85 Å |
Subunit |
Polymerase Basic Subunit 2 |
41G[5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid] , GOL |
| 6EUW |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor |
29202182 |
1.00 Å |
Subunit |
Polymerase Basic Protein 2 |
BYB[(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] , GOL |
| 4YYL |
XRD |
Virus |
Influenza A virus(FluA) |
Phenolic acid derivative bound to influenza strain H1N1 polymerase subunit PA endonuclease |
26252962 |
1.91 Å |
Subunit |
Polymerase Acidic Protein |
4KN[2-(4-fluorophenoxy)-1-(2,3,4-trihydroxyphenyl)ethanone] , SO4, MN |
| 4ZHZ |
XRD |
Virus |
Influenza A virus(FluA) |
Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region with expelling one of the metal Ions in the active site |
27088785 |
2.50 Å |
Subunit |
Polymerase Acidic Protein |
4P8[5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde] , SO4, MN |
| 4ZI0 |
XRD |
Virus |
Influenza A virus(FluA) |
Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region without a chelation to the metal Ions in the active site |
27088785 |
1.80 Å |
Subunit |
Polymerase Acidic Protein |
4P9[4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol] , SO4, MN |
| 4ZQQ |
XRD |
Virus |
Influenza A virus(FluA) |
Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region |
27088785 |
1.80 Å |
Subunit |
Polymerase Acidic Protein,Polymerase Acidic Protein |
SO4, MN |
| 5FDD |
XRD |
Virus |
Influenza A virus(FluA) |
Endonuclease inhibitor 1 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 |
27088785 |
2.51 Å |
Subunit |
Polymerase Acidic Protein,Polymerase Acidic Protein |
4P8[5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde] , SO4, MN |
| 5FDG |
XRD |
Virus |
Influenza A virus(FluA) |
Endonuclease inhibitor 3 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 |
27088785 |
2.10 Å |
Subunit |
Polymerase Acidic Protein |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , SO4, MN |
| 5I13 |
XRD |
Virus |
Influenza A virus(FluA) |
Endonuclease inhibitor 2 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 |
27088785 |
2.15 Å |
Subunit |
Polymerase Acidic Protein |
4P9[4-{(E)-[2-(4-chlorophenyl)hydrazinylidene]methyl}benzene-1,2,3-triol] , SO4, MN |
| 5JHT |
XRD |
Virus |
Influenza A virus(FluA) |
Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region crystallized with potassium sodium tartrate |
|
1.75 Å |
Subunit |
Polymerase Acidic Protein |
TLA[L(+)-TARTARIC ACID], MN |
| 5JHV |
XRD |
Virus |
Influenza A virus(FluA) |
Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region crystallized with polyethylene glycol 8000 |
|
2.75 Å |
Subunit |
Polymerase Acidic Protein |
MN |
| 6YEM |
XRD |
Virus |
Influenza A virus(FluA) |
H1N1 2009 PA endonuclease in complex with quambalarine b |
32883638 |
2.50 Å |
RNAP |
Polymerase Acidic Protein,Polymerase Acidic Protein |
OOH[3,5,6,8-tetrakis(oxidanyl)-2-pentanoyl-naphthalene-1,4-dione] , MN, CL, MG |
| 4E5I |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan bound to compound 4 |
22876176 |
2.94 Å |
Subunit |
Polymerase Protein Pa |
0N9[5-hydroxy-2-(1-methyl-1H-imidazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , SO4, MN |
| 4E5J |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan bound to compound 5 |
22876176 |
2.35 Å |
Subunit |
Polymerase Protein Pa |
581[2-[3-(acetylamino)phenyl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid] , SO4, MN |
| 4E5L |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan bound to compound 6 |
22876176 |
2.47 Å |
Subunit |
Polymerase Protein Pa |
DBH[2,3-DIHYDROXY-BENZOIC ACID] , SO4, MN |
| 4E5H |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan bound to compound 3 |
22876176 |
2.16 Å |
Subunit |
Polymerase Protein Pa |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , SO4, MN |
| 4E5E |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan apo |
22876176 |
2.05 Å |
Subunit |
Polymerase Protein Pa |
SO4, MN |
| 4E5F |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan bound to compound 1 |
22876176 |
2.39 Å |
Subunit |
Polymerase Protein Pa |
0N7[2-hydroxyisoquinoline-1,3(2H,4H)-dione] , SO4, MN |
| 4E5G |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of avian influenza virus pan bound to compound 2 |
22876176 |
2.65 Å |
Subunit |
Polymerase Protein Pa |
XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID] , SO4, MN |
| 5EG8 |
XRD |
Virus |
Influenza A virus(FluA) |
The cap binding site of influenza virus protein PB2 as a drug target |
26894672 |
1.54 Å |
Subunit |
Polymerase Basic Protein 2 |
SCN[THIOCYANATE ION] |
| 5EG7 |
XRD |
Virus |
Influenza A virus(FluA) |
The cap binding site of influenza virus protein PB2 as a drug target |
26894672 |
1.40 Å |
Subunit |
Polymerase Basic Protein 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] , GOL |
| 6YA5 |
XRD |
Virus |
Influenza A virus(FluA) |
2009 H1N1 PA endonuclease in complex with Lu2 |
32883638 |
2.00 Å |
Subunit |
Polymerase Acidic Protein |
LU2[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one] , PGE[TRIETHYLENE GLYCOL], PEG[ DI(HYDROXYETHYL)ETHER ], SO4, DMS[DIMETHYL SULFOXIDE], MN, MG |
| 7K0W |
XRD |
Virus |
Influenza A virus(FluA) |
The crystal structure of the 2009/H1N1/california PA endonuclease (construct with truncated loop 51-72) in complex with baloxavir acid |
To be published. |
2.09 Å |
Subunit |
Polymerase Acidic Protein |
E4Z ??Baloxavir acid?? SO4 ??SULFATE ION?? MN ??MANGANESE(II) ION?? |
| 4W9S |
XRD |
Virus |
Influenza A virus(FluA) |
2-(4-(1h-tetrazol-5-yl)phenyl)-5-hydroxypyrimidin-4(3h)-one bound to influenza 2009 H1N1 endonuclease |
25225968 |
1.80 Å |
Subunit |
Polymerase Acidic Protein |
3K1??5-hydroxy-2-[4-(1H-tetrazol-5-yl)phenyl]pyrimidin-4(3H)-one?? SO4 MN |
| 4MK1 |
XRD |
Virus |
Influenza A virus(FluA) |
5-bromopyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease |
23978130 |
1.85 Å |
Subunit |
Polymerase PA |
27Y ??5-bromo-3-hydroxypyridin-2(1H)-one?? SO4 EDO ??1,2-ETHANEDIOL?? MN |
| 4MK2 |
XRD |
Virus |
Influenza A virus(FluA) |
3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile bound to influenza 2009 pH1N1 endonuclease |
23978130 |
1.85 Å |
Subunit |
Polymerase PA |
28B ??3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile?? SO4 EDO ??1,2-ETHANEDIOL?? MN |
| 4MK5 |
XRD |
Virus |
Influenza A virus(FluA) |
6-(3-methoxyphenyl)pyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease |
23978130 |
1.90 Å |
Subunit |
Polymerase PA |
28A ??3-hydroxy-6-(3-methoxyphenyl)pyridin-2(5H)-one?? SO4 EDO ??1,2-ETHANEDIOL?? MN |
| 3R2V |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of polymerase basic protein 2 e538-r753 from influenza A virus a/yokohama/2017/03 H3N2 |
21904043 |
1.30 Å |
Subunit |
PB2 C-terminal Subunit |
IOD??IODIDE ION?? BO3??BORIC ACID?? |
| 6S5V |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the cap-midlink region of the H5N1 influenza A virus polymerase in complex with a cap-domain binding analogue |
31647875 |
1.35 Å |
Subunit |
Polymerase Basic Protein 2 |
KWN??(1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid?? GOL??GLYCEROL?? K |
| 3KHW |
XRD |
Virus |
Influenza A virus(FluA) |
Crystal structure of the large C-terminal domain of polymerase basic protein 2 from influenza virus a/mexico/indre4487/2009(H1N1) |
20700447 |
2.10 Å |
Subunit |
Polymerase PB2 |
GOL ??GLYCEROL?? |
| 5CXR |
XRD |
Virus |
Influenza A virus(FluA) |
Influenza endonuclease complexed with 4-bromopyrazole |
26870381 |
2.00 Å |
Subunit |
Endonuclease |
BYZ??4-bromo-1H-pyrazole??(protein binder) SO4 EDO??1,2-ETHANEDIOL?? MN |
| 4P9A |
XRD |
Virus |
Influenza A virus(FluA) |
X-ray crystal structure of PA protein from influenza strain h7n9 |
25089892 |
2.20 Å |
Subunit |
Polymerase PA |
|
| 7Z43 |
XRD |
Virus |
Influenza B virus |
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B |
35605026 |
3.12 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
IC5[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate],PO4[PHOSPHATE ION] |
| 8BDR |
EM |
Virus |
Influenza B virus |
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position |
36596301 |
2.70 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],MG |
| 7R1F |
EM |
Virus |
Influenza B virus |
Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106 |
36596301 |
2.58 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],MG |
| 8BE0 |
EM |
Virus |
Influenza B virus |
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position |
36596301 |
2.34 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],MG |
| 8BF5 |
EM |
Virus |
Influenza B virus |
Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue |
36596301 |
2.96 Å |
EC |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2 |
GTA[ P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE],G2P[PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER],MG |
| 7Z42 |
XRD |
Virus |
Influenza B virus, Homo sapiens |
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B |
35605026 |
2.42 Å |
RNAP |
Polymerase acidic protein,RNA-directed RNA polymerase catalytic subunit,Polymerase basic protein 2,RPB1 |
SEP |
| 4WRT |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase with bound vRNA promoter (form FluB2) |
25409151 |
2.70 Å |
RNAP |
PA, RNAP Catalytic Subunit, PB2 |
|
| 4WSA |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase bound to the vRNA promoter (FluB1 form) |
25409151 |
3.40 Å |
RNAP |
PA, RNAP Catalytic Subunit, PB2 |
|
| 5EPI |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase with bound 5' cRNA exhibits a novel domain arrangement |
26711008 |
4.10 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 5FML |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of the endonuclease from the PA subunit of influenza B virus bound to the PB2 subunit NLS peptide |
26711008 |
1.70 Å |
Subunit |
PB2 Subunit Of influenza B Polymerase,Pa Subunit Of influenza B Polymerase |
GOL, MG |
| 5FMZ |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase with bound 5' vRNA |
26711008 |
3.40 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 5M3J |
XRD |
Virus |
Influenza B virus(FluB) |
Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated pol II CTD |
28002402 |
3.50 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,RNAP |
|
| 5MSG |
XRD |
Virus |
Influenza B virus(FluB) |
Influenza B polymerase bound to vRNA promoter and capped RNA primer |
28126917 |
3.80 Å |
IC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
PO4 |
| 6F5O |
EM |
Virus |
Influenza B virus(FluB) |
A mechanism for the activation of the influenza virus transcriptase |
29910112 |
9.80 Å |
IC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6FS8 |
XRD |
Virus |
Influenza B virus(FluB) |
Influenza B/memphis/13/03 endonuclease with bound inhibitor, baloxavir acid (BXA) |
29941893 |
1.80 Å |
Subunit |
Polymerase Acidic Protein |
E4Z[Baloxavir acid] , MN |
| 6FS9 |
XRD |
Virus |
Influenza B virus(FluB) |
Influenza B/memphis/13/03 endonuclease with I38T mutation with bound inhibitor, baloxavir acid (BXA) |
29941893 |
2.28 Å |
Subunit |
Polymerase Acidic Protein |
E4Z[Baloxavir acid] , MN, CL |
| 6FSB |
XRD |
Virus |
influenza B virus(FluB) |
Influenza B/memphis/13/03 endonuclease with I38T mutation |
29941893 |
1.80 Å |
Subunit |
Polymerase Acidic Protein |
MN, MG |
| 6QCS |
EM |
Virus |
Influenza B virus(FluB) |
Influenza B polymerase pre-initiation complex |
31160782 |
3.10 Å |
pIC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 6QCT |
EM |
Virus |
Influenza B virus(FluB) |
Influenza B polymerase elongation complex |
31160782 |
3.20 Å |
EC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 6QCV |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP |
31160782 |
3.24 Å |
IC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
CTP[ CYTIDINE-5'-TRIPHOSPHATE ], PO4, MG |
| 6QCW |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer |
31160782 |
2.88 Å |
IC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
PO4 |
| 6QCX |
XRD |
Virus |
Influenza B virus(FluB) |
Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer |
31160782 |
3.08 Å |
IC |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
POP[ PYROPHOSPHATE 2- ], PO4, MG |
| 6T0W |
EM |
Virus |
Influenza B virus(FluB) |
Human influenza B polymerase recycling complex |
2304664 |
3.18 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6QWL |
XRD |
Virus |
Influenza B virus(FluB) |
influenza B virus (B/Panama/45) polymerase hetermotrimer in complex with 3'5' cRNA promoter |
31485076 |
4.10 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6EUX |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor |
29202182 |
2.05 Å |
Subunit |
Polymerase Basic Protein 2 |
BYB[(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid] |
| 5EF9 |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of influenza B lee PB2 cap-binding domain |
26559973 |
1.70 Å |
Subunit |
Polymerase Basic Protein 2 |
|
| 5EFA |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of influenza B lee PB2 cap-binding domain bound to m7GTP |
26559973 |
1.90 Å |
Subunit |
Polymerase Basic Protein 2 |
MGT[7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE] |
| 5EFC |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of influenza B lee PB2 cap-binding domain bound to GTP |
26559973 |
1.90 Å |
Subunit |
Polymerase Basic Protein 2 |
GTP[ Guanosine-5'-Triphosphate ] |
| 4OR6 |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of influenza B PB2 cap-binding domain with q325f mutation complex with GDP |
25691568 |
2.29 Å |
Subunit |
Polymerase Basic Protein 2 |
GDP |
| 4OR4 |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of influenza B PB2 cap-binding domain with q325f mutation complex with m7GDP |
25691568 |
2.21 Å |
Subunit |
Polymerase Basic Protein 2 |
M7G |
| 4Q46 |
XRD |
Virus |
Influenza B virus(FluB) |
The second structure of influenza B PB2 cap-binding domain complex with GDP |
25691568 |
1.80 Å |
Subunit |
Polymerase Basic Protein 2 |
GDP |
| 4ORO |
XRD |
Virus |
Influenza B virus(FluB) |
Structure of influenza B PB2 cap-binding domain complex with GDP |
To be published. |
2.40 Å |
Subunit |
Polymerase PB2 |
GDP |
| 5D98 |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus RNAP - space group P43212 |
26503046 |
3.90 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
MG |
| 5D9A |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus RNAP - space group P212121 |
26503046 |
4.30 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6F5P |
XRD |
Virus |
Influenza C virus(FluC) |
A mechanism for the activation of the influenza virus transcriptase |
29910112 |
4.14 Å |
Subunit |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,DNA-Directed RNAP Subunit |
MG |
| 6Y0C |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus polymerase in complex with human ANP32A - subClassification 2 |
33208942 |
3.20 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6XZP |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus polymerase in complex with chicken ANP32A - subClassification 4 |
33208942 |
3.30 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Lrrcap Domain-Containing Protein |
|
| 6XZR |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus polymerase in complex with chicken ANP32A - subClassification 1 |
33208942 |
3.30 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Lrrcap Domain-Containing Protein |
|
| 6XZD |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus polymerase complex without chicken ANP32A - subClassification 2 |
33208942 |
3.40 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2 |
|
| 6XZG |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus polymerase in complex with chicken ANP32A - subClassification 3 |
33208942 |
3.80 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Lrrcap Domain-Containing Protein |
|
| 6XZQ |
XRD |
Virus |
Influenza C virus(FluC) |
Influenza C virus polymerase in complex with human ANP32A - subClassification 1 |
33208942 |
3.60 Å |
RNAP |
Polymerase Acidic Protein,RNAP Catalytic Subunit,Polymerase Basic Protein 2,Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A |
|
| 6KUJ |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to cRNA promoter in Classification 1 |
31209309 |
3.40 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KUK |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to vRNA promoter in mode a conformation (Classification a1) |
31209309 |
3.90 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KUP |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to vRNA promoter in mode a conformation(Classification a2) |
31209309 |
4.30 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KUR |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to vRNA promoter in mode b conformation (Classification b1) |
31209309 |
3.70 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KUT |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to vRNA promoter in mode b conformation (Classification b2) |
31209309 |
4.10 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KUU |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to vRNA promoter in mode b conformation (Classification b3) |
31209309 |
4.00 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KUV |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus polymerase bound to cRNA promoter in Classification 2 |
31209309 |
4.10 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 6KV5 |
XRD |
Virus |
Influenza D virus(FluD) |
Structure of influenza d virus apo polymerase |
31209309 |
4.60 Å |
RNAP |
Polymerase 3,RNAP Catalytic Subunit,Polymerase PB2 |
|
| 4HDG |
XRD |
Virus |
Japanese encephalitis virus(JEV) |
Crystal structure of viral RDRP in complex with GTP |
24293643 |
2.38 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ], ZN |
| 4HDH |
XRD |
Virus |
Japanese encephalitis virus(JEV) |
Crystal structure of viral RDRP in complex with ATP |
24293643 |
2.28 Å |
RNAP |
RNAP |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], ZN |
| 4K6M |
XRD |
Virus |
Japanese encephalitis virus(JEV) |
Crystal structure of the full-length japanese encephalitis virus NS5 |
23950717 |
2.60 Å |
RNAP |
RNAP |
SAH[S-ADENOSYL-L-HOMOCYSTEINE], SO4 |
| 4MTP |
XRD |
Virus |
Japanese encephalitis virus(JEV) |
RDRP from japanesese encephalitis virus |
24293643 |
3.65 Å |
RNAP |
RNAP |
ZN |
| 7ORN |
EM |
Virus |
La Crosse virus(LACV) |
La Crosse virus polymerase at replication initiation stage |
35173159 |
2.80 Å |
IC |
La Crosse virus polymerase |
ATP[ADENOSINE-5'-TRIPHOSPHATE],MG |
| 7PLR |
XRD |
Virus |
La Crosse virus(LACV) |
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir |
|
2.64 Å |
Domain |
RNA-directed RNA polymerase L |
E4Z[Baloxavir acid],GOL[GLYCEROL],MN,FMT[FORMIC ACID] |
| 7OA4 |
XRD |
Virus |
La Crosse virus(LACV) |
Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001 |
|
2.90 Å |
Domain |
N-terminal endonuclease domain of La Crosse virus L-protein |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid],MN,FMT[FORMIC ACID] |
| 2XI5 |
XRD |
Virus |
La Crosse virus(LACV) |
N-terminal endonuclease domain of la crosse virus L-Protein |
20862319 |
2.20 Å |
Subunit |
RNAP L |
MN |
| 2XI7 |
XRD |
Virus |
La Crosse virus(LACV) |
N-terminal endonuclease domain of la crosse virus L-Protein |
20862319 |
2.20 Å |
Subunit |
RNAP L |
XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID] , MN |
| 5AMQ |
XRD |
Virus |
La Crosse virus(LACV) |
Structure of the la crosse bunyavirus polymerase in complex with the 3' and 5' viral RNA |
26004069 |
3.00 Å |
RNAP |
RNAP L |
|
| 5AMR |
XRD |
Virus |
La Crosse virus(LACV) |
Structure of the la crosse bunyavirus polymerase in complex with the 3' viral RNA |
26004069 |
2.57 Å |
RNAP |
RNAP L |
|
| 6Z6G |
EM |
Virus |
La Crosse virus(LACV) |
cryo-EM structure of la crosse virus polymerase at pre-initiation stage |
32681014 |
3.06 Å |
pIC |
RNAP L |
ZN, MG |
| 6Z6B |
XRD |
Virus |
La Crosse virus(LACV) |
Structure of full-length la crosse virus L protein (polymerase) |
32681014 |
3.96 Å |
RNAP |
RNAP L |
ZN |
| 6Z8K |
EM |
Virus |
La Crosse virus(LACV) |
La crosse virus polymerase at elongation mimicking stage |
32681014 |
3.02 Å |
EC |
RNAP L |
ZN, MG |
| 4MIW |
EM |
Virus |
Lassa mammarenavirus(LASV) |
High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase |
24516554 |
1.72 Å |
RNAP |
RNAP L |
MG |
| 6KLC |
XRD |
Virus |
Lassa mammarenavirus(LASV) |
Structure of apo lassa virus polymerase |
32214249 |
3.90 Å |
Enzyme |
RNAP L |
MN |
| 5IZH |
XRD |
Virus |
Lassa mammarenavirus(LASV) |
Lassa virus L protein cap-snatching endonuclease apo form |
27304209 |
1.85 Å |
Subunit |
RNAP L |
|
| 5J1N |
XRD |
Virus |
Lassa mammarenavirus(LASV) |
Lassa virus L protein cap-snatching endonuclease bound to one Mn2+ Ion |
27304209 |
1.09 Å |
Subunit |
RNAP L |
MPD[(4S)-2-METHYL-2,4-PENTANEDIOL], MN3[ MANGANESE (III) ION ] |
| 5J1P |
XRD |
Virus |
Lassa mammarenavirus(LASV) |
Lassa virus L protein cap-snatching endonuclease bound to twoMn2+ Ions |
27304209 |
2.36 Å |
Subunit |
RNAP L |
MN3[ MANGANESE (III) ION ] |
| 3JSB |
XRD |
Virus |
Lymphocytic choriomeningitis mammarenavirus(LCMV) |
Crystal structure of the N-terminal domain of the lymphocytic choriomeningitis virus L protein |
20862324 |
2.13 Å |
Subunit |
RNAP L |
|
| 5LTF |
XRD |
Virus |
Lymphocytic choriomeningitis mammarenavirus(LCMV) |
Crystal structure of lymphocytic choriomeningitis mammarenavirus endonuclease complexed with catalytic Ions |
29765612 |
2.43 Å |
Subunit |
RNAP L |
MG |
| 5LTN |
XRD |
Virus |
Lymphocytic choriomeningitis mammarenavirus(LCMV) |
Crystal structure of lymphocytic choriomeningitis mammarenavirus endonuclease complexed with dpba |
29765612 |
1.88 Å |
Subunit |
RNAP L |
XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID), PEG(DI(HYDROXYETHYL)ETHER] , GOL, CL, MG, NA |
| 5LTS |
XRD |
Virus |
Lymphocytic choriomeningitis mammarenavirus(LCMV) |
Crystal structure of lymphocytic choriomeningitis mammarenavirus endonuclease mutant D118A |
29765612 |
2.51 Å |
Subunit |
RNAP L |
GOL, CL, NA |
| 5T2T |
XRD |
Virus |
Lymphocytic choriomeningitis mammarenavirus(LCMV) |
Crystal structure of lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001 |
29765612 |
1.97 Å |
Subunit |
RNAP L |
0N8[(2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid] , GOL, MN, CL, NA |
| 6KLD |
XRD |
Virus |
Machupo mammarenavirus(MACV) |
Structure of apo machupo virus polymerase |
32214249 |
3.58 Å |
RNAP |
RNAP L |
ZN, MG |
| 6KLE |
XRD |
Virus |
Machupo mammarenavirus(MACV) |
Monomeric structure of machupo virus polymerase bound to vRNA promoter |
32214249 |
4.50 Å |
RNAP |
RNAP L |
ZN, MG |
| 6KLH |
XRD |
Virus |
Machupo mammarenavirus(MACV) |
Dimeric structure of machupo virus polymerase bound to vRNA promoter |
32214249 |
3.70 Å |
RNAP |
RNAP L |
ZN, MG |
| 7YF0 |
EM |
Virus |
Mammalian orthoreovirus(MRV) |
In situ structure of polymerase complex of mammalian reovirus in the core |
36469786 |
3.40 Å |
RNAP |
RNA helicase,Lambda-2 protein,RNA-directed RNA polymerase,Mu-2 protein |
ZN |
| 7YFE |
EM |
Virus |
Mammalian orthoreovirus(MRV) |
In situ structure of polymerase complex of mammalian reovirus in virion |
36469786 |
3.40 Å |
RNAP |
RNA helicase,Lambda-2 protein,RNA-directed RNA polymerase,Mu-2 protein |
ZN |
| 7YEV |
EM |
Virus |
Mammalian orthoreovirus(MRV) |
In situ structure of polymerase complex of mammalian reovirus in the pre-elongation state |
36469786 |
3.60 Å |
PEC |
RNA helicase,Lambda-2 protein,RNA-directed RNA polymerase,Mu-2 protein |
SAM[S-ADENOSYLMETHIONINE],ZN |
| 7YEZ |
EM |
Virus |
Mammalian orthoreovirus(MRV) |
In situ structure of polymerase complex of mammalian reovirus in the reloaded state |
36469786 |
3.40 Å |
PEC |
RNA helicase,Lambda-2 protein,RNA-directed RNA polymerase,Mu-2 protein |
SAM[S-ADENOSYLMETHIONINE],ZN |
| 7YED |
EM |
Virus |
Mammalian orthoreovirus(MRV) |
In situ structure of polymerase complex of mammalian reovirus in the elongation state |
36469786 |
3.00 Å |
RNAP |
RNA helicase,Lambda-2 protein,RNA-directed RNA polymerase,Mu-2 protein |
GTP[GUANOSINE-5'-TRIPHOSPHATE],UTP[URIDINE 5'-TRIPHOSPHATE],SAM[S-ADENOSYLMETHIONINE],ZN,MG |
| 1N1H |
XRD |
Virus |
Mammalian orthoreovirus(MRV) |
Initiation complex of polymerase lambda3 from reovirus |
12464184 |
2.80 Å |
IC |
Minor Core Protein Lambda 3 |
GH3[3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE], CH1[ 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE ], GDP[ GUANOSINE-5'-DIPHOSPHATE ], G7M[N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE], MN |
| 1N35 |
XRD |
Virus |
Mammalian orthoreovirus(MRV) |
Lambda3 elongation complex with four phosphodiester bond formed |
12464184 |
2.50 Å |
EC |
Minor Core Protein Lambda 3 |
CH1[ 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE ], MN |
| 1N38 |
XRD |
Virus |
Mammalian orthoreovirus(MRV) |
Reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed |
12464184 |
2.80 Å |
EC |
Minor Core Protein Lambda 3 |
U3H[3'-DEOXY-URIDINE 5'-TRIPHOSPHATE], CH1[ 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE ], MN |
| 4NYZ |
XRD |
Virus |
Mengo virus(MenV) |
The EMCV 3D pol structure with altered motif a conformation at 2.15 angstrom resolution |
24600002 |
2.15 Å |
RNAP |
RNAP |
GLN[GLUTAMINE], GOL, MG |
| 4NZ0 |
XRD |
Virus |
Mengo virus(MenV) |
The EMCV 3D pol structure at 2.8 angsrom resolution |
24600002 |
2.80 Å |
RNAP |
RNAP |
GOL, CL |
| 4Y2C |
XRD |
Virus |
Mengo virus(MenV) |
M300V 3D polymerase mutant of EMCV |
25799064 |
2.20 Å |
RNAP |
RNAP |
GOL, ACY[ACETIC ACID] |
| 4Y3C |
XRD |
Virus |
Mengo virus(MenV) |
I304V 3D polymerase mutant of EMCV |
25799064 |
3.20 Å |
RNAP |
RNAP |
GOL, CL |
| 3NAH |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structures and functional analysis of murine norovirus RNAP |
To be published. |
2.75 Å |
RNAP |
RNAP |
SO4 |
| 3NAI |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structures and functional analysis of murine norovirus RNAP |
To be published. |
2.56 Å |
RNAP |
RNAP |
URF[5-FLUOROURACIL], SO4, GOL, MN3[ MANGANESE (III) ION ], MG |
| 3QID |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structures and functional analysis of murine norovirus RNAP |
21471315 |
2.50 Å |
RNAP |
RNAP |
SO4, GOL, MN3[ MANGANESE (III) ION ] |
| 3SFG |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structure of murine norovirus RNAP in complex with 2thiouridine(2tu) |
22341781 |
2.21 Å |
RNAP |
RNAP |
2TU[1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one] , SO4, GOL, MG |
| 3SFU |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structure of murine norovirus RNAP in complex with ribavirin |
22341781 |
2.50 Å |
RNAP |
RNAP |
RBV[1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide] , SO4, GOL, MG |
| 3UPF |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structure of murine norovirus RNAP bound to nf023 |
22446684 |
2.60 Å |
RNAP |
RNAP |
0BU[8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid] , SO4 |
| 3UQS |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structures of murine norovirus RNAP |
22446684 |
2.00 Å |
RNAP |
RNAP |
SO4 |
| 3UR0 |
XRD |
Virus |
Murine norovirus(mNoV) |
Crystal structures of murine norovirus RNAP in complex with suramin |
22446684 |
2.45 Å |
RNAP |
RNAP |
SVR[8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID] , SO4 |
| 5Y3D |
XRD |
Virus |
Murine norovirus(mNoV) |
Structural insight into the interaction between RNAP and VPG for norovirus replication |
30038601 |
3.14 Å |
RNAP |
RNAP,Viral Protein Genome-Linked (VPG) |
|
| 4NRU |
XRD |
Virus |
Murine norovirus(mNoV) |
Murine norovirus RNAP in complex with compound 6, a suramin derivative |
24622391 |
2.30 Å |
RNAP |
RNAP |
2NG[4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid] , MG |
| 4O4R |
XRD |
Virus |
Murine norovirus(mNoV) |
Murine norovirus RDRP in complex with ppnds |
24657439 |
2.40 Å |
RNAP |
RNAP |
20V[3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid] , SO4 |
| 1SH0 |
XRD |
Virus |
Norovirus(NoV) |
Crystal structure of norwalk virus polymerase (triclinic) |
14764591 |
2.17 Å |
RNAP |
RNAP |
|
| 1SH2 |
XRD |
Virus |
Norovirus(NoV) |
Crystal structure of norwalk virus polymerase (metal-free, centered orthorhombic) |
14764591 |
2.30 Å |
RNAP |
RNAP |
|
| 1SH3 |
XRD |
Virus |
Norovirus(NoV) |
Crystal structure of norwalk virus polymerase (MGSO4 crystal form) |
14764591 |
2.95 Å |
RNAP |
RNAP |
MG |
| 3BSN |
XRD |
Virus |
Norovirus(NoV) |
Norwalk virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA |
18184655 |
1.80 Å |
RNAP |
RNAP |
N5C[5-nitrocytidine 5'-(tetrahydrogen triphosphate)] , GOL, MN |
| 3BSO |
XRD |
Virus |
Norovirus(NoV) |
Norwalk virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA |
18184655 |
1.74 Å |
RNAP |
RNAP |
CTP[ CYTIDINE-5'-TRIPHOSPHATE ], GOL, MN |
| 3H5X |
XRD |
Virus |
Norovirus(NoV) |
Crystal structure of 2'-amino-2'-deoxy-cytidine-5'-triphosphate bound to norovirus GII RNAP |
19426741 |
1.77 Å |
RNAP |
RNAP |
CSG[2'-amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate)] , GOL, MN |
| 3H5Y |
XRD |
Virus |
Norovirus(NoV) |
Norovirus polymerase+primer/template+CTP complex at 6 mm MnCl2 |
19426741 |
1.77 Å |
RNAP |
RNAP |
CTP[ CYTIDINE-5'-TRIPHOSPHATE ], GOL, MN |
| 4QPX |
XRD |
Virus |
Norovirus(NoV) |
NV polymerase post-incoRporation-like complex |
25478829 |
1.86 Å |
RNAP |
RNAP |
GOL, MN |
| 5TSN |
XRD |
Virus |
Norovirus(NoV) |
Crystal structures of norwalk virus polymerase bound to an RNA primer-template duplex |
28383118 |
2.10 Å |
RNAP |
RNAP |
MN |
| 2B43 |
XRD |
Virus |
Norovirus(NoV) |
Crystal structure of the norwalk virus RNAP from strain hu/nlv/dresden174/1997/ge |
To be published. |
2.30 Å |
RNAP |
RNAP |
|
| 6L42 |
XRD |
Virus |
Phlebovirus(PleV) |
Structure of severe fever with thrombocytopenia syndrome virus L protein |
32341479 |
3.40 Å |
RNAP |
RNAP |
MG |
| 6R1I |
XRD |
Virus |
Porcine kobuvirus(PKV) |
Structure of porcine aichi virus polymerase |
31415898 |
2.63 Å |
RNAP |
RNAP |
|
| 7XYA |
EM |
Virus |
Pseudomonas aeruginosa |
The cryo-EM structure of an AlpA-loading complex |
35871295 |
3.30 Å |
RNAP |
DNA-directed RNA polymerase subunit alpha,beta,beta',omega,RNA polymerase sigma factor RpoD,AlpA |
MG |
| 7XYB |
EM |
Virus |
Pseudomonas aeruginosa |
The cryo-EM structure of an AlpA-loaded complex |
35871295 |
3.70 Å |
RNAP |
DNA-directed RNA polymerase subunit alpha,beta,beta',omega,AlpA |
MG |
| 7F0R |
EM |
Virus |
Pseudomonas aeruginosa PAO1 |
Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex |
35859063 |
5.80 Å |
RNAP |
DNA-directed RNA polymerase subunit alpha,beta,beta',omega,Transcriptional factor SutA,RNA polymerase sigma factor RpoS |
ZN,MG |
| 7XL3 |
EM |
Virus |
Pseudomonas aeruginosa PAO1 |
Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes with transcription factor SutA (open lobe) |
35859063 |
3.13 Å |
RNAP |
DNA-directed RNA polymerase subunit alpha,beta,beta',omega,Transcriptional factor SutA,RNA polymerase sigma factor RpoS |
ZN,MG |
| 7XL4 |
EM |
Virus |
Pseudomonas aeruginosa PAO1 |
Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes with transcription factor SutA (closed lobe) |
35859063 |
3.86 Å |
RNAP |
DNA-directed RNA polymerase subunit alpha,beta,beta',omega,Transcriptional factor SutA,RNA polymerase sigma factor RpoS |
ZN,MG |
| 7VF9 |
EM |
Virus |
Pseudomonas aeruginosa PAO1 |
Cryo-EM structure of Pseudomonas aeruginosa RNAP sigmaS holoenzyme complexes |
|
4.04 Å |
RNAP |
DNA-directed RNA polymerase subunit alpha,beta,beta',omega,RNA polymerase sigma factor RpoS |
ZN,MG |
| 4GZK |
XRD |
Virus |
Pseudomonas phage phi12 |
Structure and interactions of the RNAP from bacteriophage phi12 |
23568335 |
1.69 Å |
RNAP |
RNAP P2 |
FMT[FORMIC ACID], MG |
| 4IEG |
XRD |
Virus |
Pseudomonas phage phi12 |
Structure and interactions of the RNAP from bacteriophage phi12 (p1 crystal form) |
23568335 |
2.10 Å |
RNAP |
RNAP P2 |
MG |
| 1HHS |
XRD |
Virus |
Pseudomonas virus phi6 |
RNAP from dsRNA bacteriophage phi6 |
11242087 |
2.00 Å |
RNAP |
RNAP(P2) |
MN |
| 1HHT |
XRD |
Virus |
Pseudomonas virus phi6 |
RNA dependent RNAP from dsRNA bacteriophage phi6 plus template |
11242087 |
2.90 Å |
RNAP |
RNAP(P2) |
MN |
| 1HI0 |
XRD |
Virus |
Pseudomonas virus phi6 |
RNAP from dsRNA bacteriophage phi6 plus initiation complex |
11242087 |
3.00 Å |
RNAP |
RNAP(P2) |
GTP[ Guanosine-5'-Triphosphate ], MN, MG |
| 1HI1 |
XRD |
Virus |
Pseudomonas virus phi6 |
RNAP from dsRNA bacteriophage phi6 plus bound NTP |
11242087 |
3.00 Å |
RNAP |
RNAP(P2) |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ] |
| 1HI8 |
XRD |
Virus |
Pseudomonas virus phi6 |
RNAP from dsRNA bacteriophage phi6 |
11242087 |
2.50 Å |
RNAP |
RNAP(P2) |
MG |
| 1UVI |
XRD |
Virus |
Pseudomonas virus phi6 |
The structural basis for RNA specificity and Ca2 inhibition of an RNAP phi6p2 with 6nt RNA |
14962391 |
2.15Å |
RNAP |
RNAP(P2) |
MN |
| 1UVJ |
XRD |
Virus |
Pseudomonas virus phi6 |
The structural basis for RNA specificity and Ca2 inhibition of an RNAP phi6p2 with 7nt RNA |
14962391 |
1.90Å |
RNAP |
RNAP(P2) |
MN |
| 1UVK |
XRD |
Virus |
Pseudomonas virus phi6 |
The structural basis for RNA specificity and Ca2 inhibition of an RNAP phi6p2 dead-end complex |
14962391 |
2.45 Å |
RNAP |
RNAP(P2) |
GTP[ Guanosine-5'-Triphosphate ], G[GUANOSINE-5'-MONOPHOSPHATE], POP[PYROPHOSPHATE 2- ], MN, MG |
| 1UVL |
XRD |
Virus |
Pseudomonas virus phi6 |
The structural basis for RNA specificity and Ca2 inhibition of an RNAP phi6p2 with 5nt RNA conformation B |
14962391 |
2.00 Å |
RNAP |
RNAP(P2) |
MN |
| 1UVM |
XRD |
Virus |
Pseudomonas virus phi6 |
The structural basis for RNA specificity and Ca2 inhibition of an RNAP phi6p2 with 5nt RNA conformation A |
14962391 |
2.00 Å |
RNAP |
RNAP(P2) |
MN |
| 1UVN |
XRD |
Virus |
Pseudomonas virus phi6 |
The structural basis for RNA specificity and Ca2 inhibition of an RNAP phi6p2 Ca2+ inhibition complex |
14962391 |
3.00 Å |
RNAP |
RNAP(P2) |
GTP[ Guanosine-5'-Triphosphate ], MN, CA |
| 1WAC |
XRD |
Virus |
Pseudomonas virus phi6 |
Back-priming mode of phi6 RNAP |
15659773 |
3.00 Å |
RNAP |
RNAP(P2) |
|
| 2JL9 |
XRD |
Virus |
Pseudomonas virus phi6 |
Structural explanation for the role of Mn in the activity of phi6 RNA- dependent RNAP |
18940872 |
3.20 Å |
RNAP |
RNAP(P2) |
|
| 2JLF |
XRD |
Virus |
Pseudomonas virus phi6 |
Structural explanation for the role of Mn in the activity of phi6 RNA- dependent RNAP |
18940872 |
3.20 Å |
RNAP |
RNAP(P2) |
MN |
| 2JLG |
XRD |
Virus |
Pseudomonas virus phi6 |
Structural explanation for the role of Mn in the activity of phi6 RNAP |
18940872 |
2.80 Å |
RNAP |
RNAP(P2) |
GTP[ Guanosine-5'-Triphosphate ], MN |
| 4A8F |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
3.30 Å |
IC,EC |
RNAP(P2) |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], MG |
| 4A8K |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
3.50 Å |
IC,EC |
RNAP(P2) |
GTP[ Guanosine-5'-Triphosphate ], MG |
| 4A8M |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
2.92 Å |
IC,EC |
RNAP(P2) |
GTP[ Guanosine-5'-Triphosphate ], ATP[ ADENOSINE-5'-TRIPHOSPHATE ], MG |
| 4A8O |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNA-dependent RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
2.67 Å |
IC,EC |
RNAP(P2) |
MN |
| 4A8Q |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
3.06 Å |
IC,EC |
RNAP(P2) |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], MG |
| 4A8S |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
2.90 Å |
IC,EC |
RNAP(P2) |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], MG |
| 4A8W |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
3.04 Å |
IC,EC |
RNAP(P2) |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], MG |
| 4A8Y |
XRD |
Virus |
Pseudomonas virus phi6 |
Non-catalytic Ions direct the RNAP of bacterial dsRNA virus phi6 from de novo initiation to elongation |
22205747 |
3.41 Å |
IC,EC |
RNAP(P2) |
ATP[ ADENOSINE-5'-TRIPHOSPHATE ], MG |
| 4B02 |
XRD |
Virus |
Pseudomonas virus phi6 |
The C-terminal priming domain Is strongly associated with the main body of bacteriophage phi6 RNAP |
22770923 |
3.30 Å |
RNAP |
RNAP(P2) |
MN |
| 5FJ6 |
EM |
Virus |
Pseudomonas virus phi6 |
Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex |
26534841 |
7.90 Å |
RNAP |
RNAP(P2) |
MN |
| 5FJ7 |
EM |
Virus |
Pseudomonas virus phi6 |
Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex, with P1 included |
26534841 |
7.90 Å |
RNAP |
Major inner Protein P1,RNAP(P2) |
MN |
| 1KHV |
XRD |
Virus |
Rabbit hemorrhagic disease virus(RHDV) |
Crystal structure of rabbit hemorrhagic disease virus RNAP complexed with Lu3+ |
11677245 |
2.50 Å |
RNAP |
RNAP |
LU(LUTETIUM (III) ION) |
| 1KHW |
XRD |
Virus |
Rabbit hemorrhagic disease virus(RHDV) |
Crystal structure of rabbit hemorrhagic disease virus RNAP complexed withMn2+ |
11677245 |
2.70 Å |
RNAP |
RNAP |
MN |
| 6UEB |
XRD |
Virus |
Rabies virus(RabV) |
Structure of rabies sad-b19 L-P complex from cryo-EM |
31953264 |
3.30 Å |
RNAP |
L Protein,Phosphoprotein |
ZN |
| 1VYI |
XRD |
Virus |
Rabies virus(RabV) |
Structure of the C-terminal domain of the polymerase cofactor of rabies virus: insights in function and evolution. |
15476803 |
1.50 Å |
Subunit |
RNAP Alpha Subunit |
GOL ??GLYCEROL?? |
| 1MUK |
XRD |
Virus |
Reovirus(ReoV) |
Reovirus RNAP lambda3 native structure |
12464184 |
2.50 Å |
RNAP |
Minor Core Protein Lambda 3 |
|
| 1MWH |
XRD |
Virus |
Reovirus(ReoV) |
Reovirus RNAP lambda3 bound to mRNA cap analog |
12464184 |
2.50 Å |
RNAP |
Minor Core Protein Lambda 3 |
GTG[7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE], MN |
| 1UON |
EM |
Virus |
Reovirus(ReoV) |
Reovirus polymerase lambda-3 localized by electron cryomicroscopy of virions at 7.6 angstrom resolution |
14608373 |
7.60 Å |
RNAP |
Minor Core Protein Lambda 3 |
CH1[ 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE ], MN |
| 6PZK |
EM |
Virus |
Respiratory syncytial virus(RSV) |
cryo-EM structure of the respiratory syncytial virus polymerase (L) protein bound by the tetrameric phosphoprotein (P) |
31495574 |
3.20 Å |
RNAP |
RNAP L,Phosphoprotein |
|
| 6UEN |
EM |
Virus |
Respiratory syncytial virus(RSV) |
cryo-EM structure of the respiratory syncytial virus RNAP |
31953395 |
3.67 Å |
RNAP |
RNAP L,Phosphoprotein |
|
| 6OGY |
EM |
Virus |
Rotavirus A(RVA) |
In situ structure of rotavirus RNAP at duplex-open state |
31101900 |
3.40 Å |
RNAP |
RNAP, inner Capsid Protein VP2 |
|
| 6OGZ |
EM |
Virus |
Rotavirus A(RVA) |
In situ structure of rotavirus RNAP at transcript-elongated state |
31101900 |
3.60 Å |
RNAP |
RNAP ,inner Capsid Protein VP2 |
GTP[ Guanosine-5'-Triphosphate ], UTP[ URIDINE 5'-TRIPHOSPHATE ] |
| 1QLN |
XRD |
Virus |
Sapporo virus(SapV) |
Structure of a transcribing T7 RNAP initiation complex |
10600732 |
2.40 Å |
IC |
T7 RNAP |
|
| 2CKW |
XRD |
Virus |
Sapporo virus(SapV) |
The 2.3 angstrom resolution structure of the sapporo virus RNA dependant RNAP |
17121797 |
2.30 Å |
RNAP |
RNAP |
|
| 2UUT |
XRD |
Virus |
Sapporo virus(SapV) |
The 2.4 angstrom resolution structure of the D346G mutant of the sapporo virus RDRP polymerase |
To be published. |
2.40 Å |
RNAP |
RNAP |
|
| 2UUW |
XRD |
Virus |
Sapporo virus(SapV) |
2.75 angstrom structure of the d347g d348g mutant structure of sapporo virus RDRP polymerase |
To be published. |
2.76 Å |
RNAP |
RNAP |
|
| 2WK4 |
XRD |
Virus |
Sapporo virus(SapV) |
Dimeric structure of D347G D348G mutant of the sapporovirus RNAP |
To be published. |
2.98 Å |
RNAP |
RNAP |
|
| 6NUS |
XRD |
Virus |
SARS-COV |
SARS-coronavirus nsp12 bound to nsp8 co-factor |
31138817 |
3.50 Å |
RNAP |
Nsp12,Nsp8 |
ZN |
| 6NUR |
XRD |
Virus |
SARS-COV |
SARS-coronavirus nsp12 bound to nsp7 and nsp8 co-factors |
31138817 |
3.10 Å |
RNAP |
Nsp12,Nsp8,Nsp7 |
ZN |
| 6M71 |
XRD |
Virus |
SARS-COV-2 |
SARS-COV-2 RNAP in complex with cofactors |
32277040 |
2.90 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
|
| 6YYT |
XRD |
Virus |
SARS-COV-2 |
Structure of replicating SARS-COV-2 polymerase |
32438371 |
2.90 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN |
| 7BTF |
XRD |
Virus |
SARS-COV-2 |
SARS-COV-2 RNAP in complex with cofactors in reduced condition |
32277040 |
2.95 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN |
| 7BV1 |
XRD |
Virus |
SARS-COV-2 |
cryo-EM structure of the apo nsp12-nsp7-nsp8 complex |
32358203 |
2.80 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN |
| 7BV2 |
XRD |
Virus |
SARS-COV-2 |
The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of remdesivir(rtp) |
32358203 |
2.50 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
F86[[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate] , POP[ PYROPHOSPHATE 2- ], ZN, MG |
| 7BZF |
XRD |
Virus |
SARS-COV-2 |
Covid-19 RNAP post-translocated catalytic complex |
32526208 |
3.26 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN |
| 7C2K |
XRD |
Virus |
SARS-COV-2 |
Covid-19 RNAP pre-translocated catalytic complex |
32526208 |
2.93 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN |
| 7B3D |
XRD |
Virus |
SARS-COV-2 |
Structure of elongating SARS-COV-2 RNAP with AMP at position -4 (structure 3) |
33436624 |
2.80 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN |
| 7AAP |
XRD |
Virus |
SARS-COV-2 |
Nsp7-nsp8-nsp12 SARS-COV2 RNAP in complex with template:primer dsRNA and favipiravir-rtp |
33526596 |
2.50 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
GE6[[[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonyl-5-fluoranyl-2-oxidanylidene-pyrazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate] , POP[ PYROPHOSPHATE 2- ], ZN, MG |
| 7CTT |
XRD |
Virus |
SARS-COV-2 |
Cryo-EM structure of favipiravir bound to replicating polymerase complex of SARS-COV-2 in the pre-catalytic state. |
33521757 |
3.20 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
GE6[[[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonyl-5-fluoranyl-2-oxidanylidene-pyrazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate] , ZN, MG |
| 6XQB |
XRD |
Virus |
SARS-COV-2 |
SARS-COV-2 RDRP/RNA complex |
To be published. |
3.40 Å |
RNAP |
Nsp12,Nsp7,Nsp8 |
ZN, MG |
| 7CXN |
XRD |
Virus |
SARS-COV-2 |
Architecture of a SARS-COV-2 mini replication and transcription complex |
33208736 |
3.84 Å |
RNAP |
Nsp12,Nsp8,Nsp7,Helicase |
ZN |
| 7CXM |
XRD |
Virus |
SARS-COV-2 |
Architecture of a SARS-COV-2 mini replication and transcription complex |
33208736 |
2.90 Å |
RNAP |
Nsp12,Nsp8,Nsp7,Helicase |
ZN |
| 7BW4 |
XRD |
Virus |
SARS-COV-2 |
Structure of the RNAP from SARS-COV-2 |
32531208 |
3.70 Å |
RNAP |
Nsp12,Nsp8,Nsp7 |
ZN |
| 7B3C |
XRD |
Virus |
SARS-COV-2 |
Structure of elongating SARS-COV-2 RNAP with remdesivir at position -4 (structure 2) |
33436624 |
3.40 Å |
RNAP |
Nsp12,Nsp8,Nsp7 |
ZN |
| 7B3B |
XRD |
Virus |
SARS-COV-2 |
Structure of elongating SARS-COV-2 RNAP with remdesivir at position -3 (structure 1) |
33436624 |
3.10 Å |
RNAP |
Nsp12,Nsp8,Nsp7 |
ZN |
| 7D4F |
XRD |
Virus |
SARS-COV-2 |
Structure of covid-19 RNAP bound to suramin |
33674802 |
2.57 Å |
RNAP |
Nsp12,Nsp8,Nsp7 |
H3U ??8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid?? Zn |
| 7CYQ |
XRD |
Virus |
SARS-COV-2 |
Cryo-EM structure of an extended SARS-COV-2 replication and transcription complex reveals an intermediate state in cap synthesis |
33232691 |
2.83 Å |
TC |
Nsp12,Nsp8,Nsp7,Helicase |
GDP ZN MG |
| 6WTC |
XRD |
Virus |
SARS-COV-2 |
Crystal structure of the second form of the co-factor complex of nsp7 and the C-terminal domain of nsp8 from SARS-COV-2 |
To be published. |
1.85 Å |
Subunit |
Nsp7,Nsp8 |
ACY [ ACETIC ACID ] |
| 6WIQ |
XRD |
Virus |
SARS-COV-2 |
Crystal structure of the co-factor complex of nsp7 and the C-terminal domain of nsp8 from SARS-COV-2 |
34197805 |
2.85 Å |
Subunit |
Nsp7,Nsp8 |
|
| 6WQD |
XRD |
Virus |
SARS-COV-2 |
The 1.95 a crystal structure of the co-factor complex of nsp7 and the C-terminal domain of nsp8 from SARS-COV-2 |
34197805 |
1.95 Å |
Subunit |
Nsp7,Nsp8 |
EDO[ 1,2-ETHANEDIOL ] |
| 6XIP |
XRD |
Virus |
SARS-COV-2 |
The 1.5 a crystal structure of the co-factor complex of nsp7 and the C-terminal domain of nsp8 from SARS-COV-2 |
34197805 |
1.50 Å |
Subunit |
Nsp7,Nsp8 |
EDO[ 1,2-ETHANEDIOL ] |
| 7OZV |
EM |
Virus |
SARS-CoV-2 |
SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G |
34381216 |
3.20Å |
RNAP |
Replicase polyprotein 1ab,Non-structural protein 8,Non-structural protein 7 |
ZN |
| 7OZU |
EM |
Virus |
SARS-CoV-2 |
SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A |
34381216 |
3.30Å |
RNAP |
Replicase polyprotein 1ab,Non-structural protein 8,Non-structural protein 7 |
ZN |
| 7DFG |
EM |
Virus |
SARS-CoV-2 |
Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir |
To be published |
2.70Å |
RNAP |
RdRp,Non-structural protein 8,Non-structural protein 7 |
1RP[6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide],POP,ZN ,MG |
| 7L1F |
EM |
Virus |
SARS-CoV-2 |
SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate |
33631104 |
3.89Å |
RNAP |
RdRp,Non-structural protein 8,Non-structural protein 7 |
|
| 7DOK |
EM |
Virus |
SARS-CoV-2 |
Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir |
To be published. |
2.73Å |
RNAP |
RdRp,Non-structural protein 8,Non-structural protein 7 |
HCU[ [(2R)-4-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-(hydroxymethyl)butyl] dihydrogen phosphate ],POP[ PYROPHOSPHATE 2- ],ZN,MG |
| 7DOI |
EM |
Virus |
SARS-CoV-2 |
Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir. |
To be published. |
2.60Å |
RNAP |
RdRp,Non-structural protein 8,Non-structural protein 7 |
HCU[ [(2R)-4-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-(hydroxymethyl)butyl] dihydrogen phosphate ],POP[ PYROPHOSPHATE 2- ],ZN,MG |
| 7DFH |
EM |
Virus |
SARS-CoV-2 |
Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin |
To be published. |
2.97Å |
RNAP |
RdRp,Non-structural protein 8,Non-structural protein 7 |
RVP[ RIBAVIRIN MONOPHOSPHATE ] , POP[ PYROPHOSPHATE 2- ] ZN MG |
| 7AOC |
EM |
Virus |
Schizosaccharomyces pombe |
Schizosaccharomyces pombe RNA polymerase I (monomer) |
33536435 |
3.84Å |
RNAP |
RNAP |
ZN |
| 6XYA |
XRD |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Cap-binding domain of sftsv L protein |
32313945 |
1.35 Å |
Subunit |
RNAP |
MGP[7-METHYL-GUANOSINE-5'-TRIPHOSPHATE], NA |
| 6Y6K |
XRD |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Cryo-EM structure of a phenuiviridae L protein |
32313945 |
3.78 Å |
RNAP |
RNAP |
MG |
| 8AS6 |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK] |
36651274 |
3.40 Å |
Domain |
RNA-dependent RNA-polymerase L protein |
|
| 8ASB |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO] |
36651274 |
3.60 Å |
Domain |
RNA-dependent RNA-polymerase L protein |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine], MG |
| 8ASG |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein bound in a resting state [RESTING] |
36651274 |
3.20 Å |
Domain |
RNA-dependent RNA-polymerase L protein |
MG |
| 8AS7 |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION] |
36651274 |
2.60 Å |
EC |
RNA-dependent RNA-polymerase L protein |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine],EPE[4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID],MG |
| 8ASD |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] |
36651274 |
2.60 Å |
EC |
RNA-directed RNA polymerase |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine],MG |
| 8AS7 |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION] |
36651274 |
2.60 Å |
EC |
RNA-dependent RNA-polymerase L protein |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine],EPE[4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID],MG |
| 8ASD |
EM |
Virus |
Severe fever with thrombocytopenia syndrome virus(SFTSV) |
Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] |
36651274 |
2.60 Å |
EC |
RNA-directed RNA polymerase |
2KH[5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine],MG |
| 6QWT |
XRD |
Virus |
Sicinivirus(SicV) |
Sicinivirus 3D pol RNAP |
31415898 |
2.30 Å |
RNAP |
RNAP |
|
| 2R7O |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of VP1 apoenzyme of rotavirus SA11 (N-terminal hexahistidine-tagged) |
19000820 |
3.35 Å |
RNAP |
RNAP |
|
| 2R7Q |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of VP1 apoenzyme of rotavirus SA11 (C-terminal hexahistidine-tagged) |
19000820 |
2.90 Å |
RNAP |
RNAP |
|
| 2R7R |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/RNA (UGUGACC) complex |
19000820 |
2.60 Å |
RNAP |
RNAP |
|
| 2R7S |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/ RNA (UGUGCC) complex |
19000820 |
3.24 Å |
RNAP |
RNAP |
PO4 |
| 2R7T |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/RNA (UGUGAACC) complex |
19000820 |
3.00 Å |
RNAP |
RNAP |
|
| 2R7U |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/RNA (AAAAGCC) complex |
19000820 |
3.10 Å |
RNAP |
RNAP |
|
| 2R7V |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/RNA (GGCUUU) complex |
19000820 |
2.80 Å |
RNAP |
RNAP |
|
| 2R7W |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/RNA (UGUGACC)/mRNA 5'-cap (M7GPPPG) complex |
19000820 |
2.60 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ] |
| 2R7X |
XRD |
Virus |
Simian rotavirus(SiRV) |
Crystal structure of rotavirus SA11 VP1/RNA (UGUGACC)/gtp complex |
19000820 |
2.80 Å |
RNAP |
RNAP |
GTP[ Guanosine-5'-Triphosphate ] |
| 6OJ3 |
EM |
Virus |
Simian rotavirus(SiRV) |
In situ structure of rotavirus VP1 RNAP (TLP) |
31233764 |
4.50 Å |
RNAP |
inner Capsid Protein VP2,RNAP |
|
| 6OJ4 |
EM |
Virus |
Simian rotavirus(SiRV) |
In situ structure of rotavirus VP1 RNAP (dlp) |
31233764 |
3.30 Å |
RNAP |
inner Capsid Protein VP2,RNAP |
|
| 6OJ5 |
EM |
Virus |
Simian rotavirus(SiRV) |
In situ structure of rotavirus VP1 RNAP (TLP_RNA) |
31233764 |
5.20 Å |
RNAP |
inner Capsid Protein VP2,RNAP |
|
| 6OJ6 |
EM |
Virus |
Simian rotavirus(SiRV) |
In situ structure of rotavirus VP1 RNAP (DLP_RNA) |
31233764 |
4.20 Å |
RNAP |
inner Capsid Protein VP2,RNAP |
|
| 7OK0 |
EM |
Virus |
Sulfolobus acidocaldarius |
Cryo-EM structure of the Sulfolobus acidocaldarius RNA polymerase at 2.88 A |
34535646 |
2.90Å |
RNAP |
RNAP |
F3S[FE3-S4 CLUSTER],ZN,MG |
| 7OQ4 |
EM |
Virus |
Sulfolobus acidocaldarius,Acidianus two-tailed virus |
Cryo-EM structure of the ATV RNAP Inhibitory Protein (RIP) bound to the DNA-binding channel of the host RNA polymerase |
34535646 |
3.27Å |
RNAP |
RNAP,RNAP inhibitory protein |
F3S[FE3-S4 CLUSTER],ZN,MG |
| 7OQY |
EM |
Virus |
Sulfolobus acidocaldarius,Saccharolobus solfataricus |
Cryo-EM structure of the cellular negative regulator TFS4 bound to the archaeal RNA polymerase |
34535646 |
2.61Å |
RNAP |
RNAP,RpoM-2 |
F3S[FE3-S4 CLUSTER],ZN,MG |
| 8HSR |
EM |
Virus |
Thermus thermophilus HB8 |
Thermus thermophilus Rho-engaged RNAP elongation complex |
36753546 |
4.00Å |
EM |
Transcription termination factor Rho,RNAP |
ADP,BEF,ZN,MG |
| 4CHD |
XRD |
Virus |
Thogotovirus(ThoV) |
Crystal structure of the '627' domain of the PB2 subunit of thogoto virus polymerase |
24454773 |
2.40 Å |
Subunit |
Polymerase Acidic Protein |
|
| 4CHE |
XRD |
Virus |
Thogotovirus(ThoV) |
Crystal structure of the putative cap-binding domain of the PB2 subunit of thogoto virus polymerase |
24454773 |
1.80 Å |
Subunit |
Polymerase Basic Protein |
|
| 4CHF |
XRD |
Virus |
Thogotovirus(ThoV) |
Crystal structure of the putative cap-binding domain of the PB2 subunit of thogoto virus polymerase (form 2) |
24454773 |
3.00 Å |
Subunit |
Polymerase Basic Protein |
|
| 4CGX |
XRD |
Virus |
Thogotovirus(ThoV) |
Crystal structure of the N-terminal domain of the PA subunit of thogoto virus polymerase (form 1) |
24454773 |
2.70 Å |
Subunit |
Polymerase Acidic Protein |
|
| 4CHC |
XRD |
Virus |
Thogotovirus(ThoV) |
Crystal structure of the N-terminal domain of the PA subunit of thogoto virus polymerase (form 2) |
24454773 |
2.77 Å |
Subunit |
Polymerase Acidic Protein |
|
| 4CGS |
XRD |
Virus |
Thogotovirus(ThoV) |
Crystal structure of the N-terminal domain of the PA subunit of dhori virus polymerase |
24454773 |
1.30 Å |
Subunit |
Polymerase Acidic Protein |
GOL,CME |
| 4XHA |
XRD |
Virus |
Thosea asigna virus(TAV) |
Crystal structure of thosea asigna virus RNAP (RDRP) complexed with lu3+ |
26625123 |
3.00 Å |
RNAP |
RNAP |
LU(LUTETIUM (III) ION), SO4, GOL |
| 4XHI |
XRD |
Virus |
Thosea asigna virus(TAV) |
Crystal structure of native thosea asigna virus RNAP (RDRP) at 2.15 angstrom resolution |
26625123 |
2.15 Å |
RNAP |
RNAP |
SO4, GOL |
| 5CX6 |
XRD |
Virus |
Thosea asigna virus(TAV) |
Crystal structure of thosea asigna virus RNAP (RDRP) complexed with CDP |
26625123 |
2.10 Å |
RNAP |
RNAP |
CDP (CYTIDINE-5'-DIPHOSPHATE), SO4, GOL, MG |
| 5CYR |
XRD |
Virus |
Thosea asigna virus(TAV) |
Crystal structure of thosea asigna virus RNAP (RDRP) complexed with ATP and ssRNA |
26625123 |
3.50 Å |
RNAP |
RNAP |
ATP (ADENOSINE-5'-TRIPHOSPHATE), SO4, PO4, MG |
| 7D6N |
XRD |
Virus |
Tick-borne encephalitis virus(TBEV) |
Crystal structure of tick-borne encephalitis virus RNAP |
|
3.17 Å |
RNAP |
RNAP |
ZN, MG |
| 6QW5 |
XRD |
Virus |
Toscana virus(TosV) |
Structure and function of the toscana virus cap snatching endonuclease |
31584100 |
1.99 Å |
Subunit |
RNAP |
XI7[2-4-DIOXO-4-PHENYLBUTANOIC ACID], SO4, MN |
| 6QVV |
XRD |
Virus |
Toscana virus(TosV) |
Structure and function of phenuiviridae cap snatching endonucleases |
31584100 |
2.40 Å |
Subunit |
RNAP |
SO4, GOL, MN3[ MANGANESE (III) ION ] |
| 6QW0 |
XRD |
Virus |
Toscana virus(TosV) |
Structure and function of toscana virus cap snatching endonucleases |
31584100 |
1.50 Å |
Subunit |
RNAP |
SO4, GOL, MN3[ MANGANESE (III) ION ] |
| 7AOH |
EM |
Virus |
Vaccinia virus GLV-1h68 |
Atomic structure of the poxvirus late initially transcribing complex |
34556871 |
2.70Å |
RNAP |
RNAP |
ZN,MG |
| 7AOZ |
EM |
Virus |
Vaccinia virus GLV-1h68 |
Atomic structure of the poxvirus transcription initiation complex in conformation 1 |
34556871 |
2.85Å |
IC |
RNAP |
ZN,MG |
| 7AP8 |
EM |
Virus |
Vaccinia virus GLV-1h68 |
Atomic structure of the poxvirus initially transcribing complex in conformation 2 |
34556871 |
3.15Å |
IC |
RNAP |
ZN,MG |
| 7AP9 |
EM |
Virus |
Vaccinia virus GLV-1h68 |
Atomic structure of the poxvirus initially transcribing complex in conformation 3 |
34556871 |
3.01Å |
IC |
RNAP |
ZN,MG |
| 7AMV |
EM |
Virus |
Vaccinia virus GLV-1h68 |
Atomic structure of the poxvirus transcription pre-initiation complex in the initially melted state |
34556871 |
2.80Å |
IC |
RNAP |
ZN,MG |
| 6RFL |
EM |
Virus |
Vaccinia virus(VacV) |
Structure of the complete vaccinia DNA-dependent RNA polymerase complex |
31835032 |
2.76 Å |
RNAP |
RNAP subunit Rpo132/19 kDa subunit/Rpo18/Rpo7/Rpo147,TF RAP94/VETF 82kDa large subunit,Virion core protein |
ZN MG |
| 5A22 |
EM |
Virus |
Vesicular stomatitis virus(VSV) |
Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy |
26144317 |
3.80 Å |
RNAP |
RNAP L |
ZN |
| 6U1X |
EM |
Virus |
Vesicular stomatitis virus(VSV) |
Structure of the vesicular stomatitis virus L protein in complex with its phosphoprotein cofactor (3.0 angstrom resolution) |
31914397 |
3.00 Å |
RNAP |
RNAP L, Phosphoprotein |
ZN |
| 5CHS |
EM |
Virus |
Vesicular stomatitis virus(VSV) |
N-terminal domain of the vesicular stomatitis virus L protein |
26512087 |
1.80 Å |
Subunit |
RNAP L |
1PE[PENTAETHYLENE GLYCOL], NA |
| 2HCN |
XRD |
Virus |
West nile virus(WNV) |
Crystal structure of RNAP domain from west nile virus |
17287213 |
2.35 Å |
RNAP |
RNAP (NS5) |
ZN, CA |
| 2HCS |
XRD |
Virus |
West nile virus(WNV) |
Crystal structure of RNA dependant RNAP domain of west nile virus |
17287213 |
2.50 Å |
RNAP |
RNAP (NS5) |
ZN |
| 2HFZ |
XRD |
Virus |
West nile virus(WNV) |
Crystal structure of RNAP domain from west nile virus |
17287213 |
3.00 Å |
RNAP |
RNAP (NS5) |
ZN, MG |
| 3EVD |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of GTP complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine |
19101564 |
1.50 Å |
Subunit |
RNAP NS5 |
GTP[ Guanosine-5'-Triphosphate ], SAH[S-ADENOSYL-L-HOMOCYSTEINE] |
| 3EVC |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of GTP complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine |
19101564 |
1.60 Å |
Subunit |
RNAP NS5 |
GTP[ Guanosine-5'-Triphosphate ], SAH[S-ADENOSYL-L-HOMOCYSTEINE] |
| 6QSN |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of yellow fever virus polymerase NS5A |
31202975 |
3.00 Å |
RNAP |
RNAP NS6 |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4, ZN |
| 3EVF |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of Me7-Gpppa complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine |
19101564 |
1.45 Å |
Subunit |
RNAP NS5 |
GTA[ P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE ], SAH[ S-ADENOSYL-L-HOMOCYSTEINE ] |
| 3EVE |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of Gpppa complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine |
19101564 |
1.70 Å |
Subunit |
RNAP NS5 |
|
| 3EVB |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of yellow fever virus methyltransferase complexed with s-adenosyl-l-homocysteine |
19101564 |
1.85 Å |
Subunit |
RNAP NS5 |
SAH [ S-ADENOSYL-L-HOMOCYSTEINE ] |
| 3EVA |
XRD |
Virus |
Yellow fever virus(YFV) |
Crystal structure of yellow fever virus methyltransferase complexed with s-adenosyl-l-homocysteine |
19101564 |
1.50 Å |
Subunit |
RNAP NS5 |
SAH [ S-ADENOSYL-L-HOMOCYSTEINE ] |
| 7W82 |
XRD |
Virus |
Zea mays |
Crystal structure of maize RDR2 |
35188193 |
3.10 Å |
RNAP |
RNA-dependent RNA polymerase |
|
| 7W84 |
EM |
Virus |
Zea mays |
CryoEM structure of apo form ZmRDR2 at 3.4 Angstroms resolution |
35188193 |
3.40 Å |
RNAP |
RNA-dependent RNA polymerase |
|
| 7W88 |
EM |
Virus |
Zea mays |
CryoEM structure of open form ZmRDR2 at 3.5 Angstroms resolution |
35188193 |
3.50 Å |
RNAP |
RNA-dependent RNA polymerase |
|
| 5U04 |
XRD |
Virus |
Zika virus(ZIKV) |
Crystal structure of zika virus NS5 RNAP |
28345596 |
1.90 Å |
RNAP |
RDRP(NS5) |
PO4, ZN |
| 5U0C |
XRD |
Virus |
Zika virus(ZIKV) |
Structure of zika virus NS5 RNAP domain |
28345656 |
3.00 Å |
RNAP |
RDRP(NS5) |
ZN |
| 5WZ3 |
XRD |
Virus |
Zika virus(ZIKV) |
Crystal structure of zika virus NS5 RNAP(RDRP) |
28254839 |
1.80 Å |
RNAP |
RDRP(NS5) |
ZN |
| 6LD1 |
XRD |
Virus |
Zika virus(ZIKV) |
Zika NS5 polymerase domain |
32796069 |
1.40 Å |
RNAP |
RDRP(NS5) |
EDO[ 1,2-ETHANEDIOL ], ZN |
| 6LD3 |
XRD |
Virus |
Zika virus(ZIKV) |
Zika NS5 polymerase domain |
32796069 |
2.30 Å |
RNAP |
RDRP(NS5) |
G8O[ 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid ] , FB2( benzenesulfonamide ), ZN |
| 6LD4 |
XRD |
Virus |
Zika virus(ZIKV) |
Zika NS5 polymerase domain |
32796069 |
1.50 Å |
RNAP |
RDRP(NS5) |
G8O[ 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid ] , G8F( 3-methoxybenzenesulfonamide ), ZN |
| 6LD5 |
XRD |
Virus |
Zika virus(ZIKV) |
Zika NS5 polymerase domain |
32796069 |
1.94 Å |
RNAP |
RDRP(NS5) |
G8O[ 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid ] , G8L( quinoline-8-sulfonamide ), ZN |
| 6I7P |
XRD |
Virus |
Zika virus(ZIKV) |
Crystal structure of the full-length zika virus NS5 protein (human Isolate z1106033) |
30951555 |
3.98 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], PO4, ZN |
| 6LD2 |
XRD |
Virus |
Zika virus(ZIKV) |
Zika NS5 polymerase domain |
32796069 |
1.40 Å |
RNAP |
RDRP(NS5) |
KY3 [ (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid ] , ZN |
| 5NJU |
XRD |
Virus |
Zika virus(ZIKV) |
Flavivirus NS5 domain |
29423037 |
2.10 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], MG |
| 5NJV |
XRD |
Virus |
Zika virus(ZIKV) |
Flavivirus NS5 domain |
29423037 |
2.00 Å |
RNAP |
RDRP(NS5) |
SAM[ S-ADENOSYLMETHIONINE ], CL |
| 6WCZ |
EM |
Virus |
Zika virus(ZIKV) |
Cryo-EM structure of full-length zikv NS5-hstat2 complex |
32778820 |
4.00 Å |
Subunit |
Signal Transducer And Activator Of Transcription 2,Non-Structural Protein 5 |
ZN |
| 6UX2 |
EM |
Virus |
Zika virus(ZIKV) |
Crystal structure of zikv RDRP in complex with stat2 |
32778820 |
3.01 Å |
RNAP |
Signal Transducer And Activator Of Transcription 2,Nonstructural Protein 5 |
SO4, ZN |
| 5TFR |
XRD |
Virus |
Zika virus(ZIKV) |
Crystal structure of zika virus NS5 protein |
28291746 |
3.05 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], ZN |
| 5TMH |
XRD |
Virus |
Zika virus(ZIKV) |
Structure of zika virus NS5 |
28345600 |
3.28 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4, GOL,ZN |
| 5U0B |
XRD |
Virus |
Zika virus(ZIKV) |
Structure of full-length zika virus NS5 |
28345656 |
3.00 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ], SO4, GOL,ZN |
| 5M2X |
XRD |
Virus |
Zika virus(ZIKV) |
Crystal structure of the full-length zika virus NS5 protein (human Isolate z1106033) |
30951555 |
4.99 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],PO4,ZN |
| 5M2Z |
XRD |
Virus |
Zika virus(ZIKV) |
Crystal structure of the full-length zika virus NS5 protein (human Isolate z1106033) |
30951555 |
4.80 Å |
RNAP |
RDRP(NS5) |
SAH[ S-ADENOSYL-L-HOMOCYSTEINE ],PO4,ZN |